ICRS virtual convention 2021: Orthoregenerative therapy from basic science to clinical application

Abstract

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Orthopedic Joint Preservation: A Comprehensive Review

“…Biologic treatments incorporate tissue engineering strategies such as cells, scaffolds, and signaling molecules [41]. Orthoregenerative strategies, including blood-derivatives, stem cells, and engineering strategies, have shown promise in modulating and improving the healing response [4]. The articular cartilage of the joint has limited healing capacity, making the repair of cartilage damage challenging.…”

“…Tissue engineering strategies incorporate cells, scaffolds, and signaling molecules to facilitate the healing mechanism of tissues with limited healing potential, such as tendons, cartilage, meniscus, and ligaments [41]. Orthoregenerative strategies aim to modulate and improve the body's healing response, and recent research has focused on blood-derivatives, stem cells, biomechanical concepts, and engineering strategies [4]. MSCs have the potential to differentiate into multi-lineage cells and possess immunomodulatory properties, making them a promising therapeutic agent for osteoarthritis (OA) [46,47].…”

“…Patient education plays a crucial and indispensable role in the advancement and progress of promoting adherence to rehabilitation protocols, thereby augmenting and enhancing the comprehension and appreciation of the utmost significance and value of joint preservation. [4]. The clinical and functional results, obtained from a comprehensive evaluation of patients' general health and welfare, encompass a comprehensive examination of both the physiological and psychological aspects of their state.…”

Revisiting the role of hyperbaric oxygen therapy in knee injuries: Potential benefits and mechanisms

“…Research efforts have been intensified to identify new therapeutic approaches for both ligament/tendon and cartilage injuries aiming to prevent, or at least decelerate the development of osteoarthritis (Demange et al, 2014; Dunkin & Lattermann, 2013; Gomoll & Minas, 2014). Those techniques provide different quality of reparative tissue that ranges from fibrous tissue, fibrocartilage, hyaline‐like and hyaline cartilage (C. B. G. Leite et al, 2021; Smith et al, 2005).…”

Efeito da oxigenoterapia hiperbárica na reconstrução do ligamento cruzado anterior em modelo experimental em coelhos

“…Entretanto, a maioria dessas estratégias ainda correspondem a investigações pré-clínicas, e que, portanto, não estão amplamente disponíveis à população. Além disso, grande parte dessas medidas envolvem materiais que requerem manipulação biológica ou procedimentos invasivos para seu uso e aplicação, o que traz barreiras legais e financeiras, e maior morbidade aos pacientes 199 .…”