Ice-mould freeze casting of porous ceramic components

Moritz, Tassilo; Richter, Hans‐Jürgen

doi:10.1016/j.jeurceramsoc.2007.04.010

Cited by 59 publications

(43 citation statements)

References 16 publications

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“…The applications considered so far belongs to two main groups: [17,24,[30][31][32][33][34][35]45,69,70] The structure of the porous ceramics obtained by freezecasting being very similar to that of natural biomaterials such as nacre or bone, [72] biomaterials has become a field with potentially important applications of this technology, with REVIEWS particular attention to tissue engineering. Preliminary reports of dramatic improvements of the compressive strength of freeze-casted hydroxyapatite seem to confirm that potential, [17] and the assessment of the biological response of these materials is under way in various laboratories.…”

Section: Applications Of Porous Freeze-casted Ceramicsmentioning

confidence: 99%

Freeze‐Casting of Porous Ceramics: A Review of Current Achievements and Issues

2008

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Freeze‐casting, the templating of porous structures by the solidification of a solvent, have seen a great deal of efforts during the last few years. Of particular interest are the unique structure and properties exhibited by porous freeze‐casted ceramics, which opened new opportunities in the field of cellular ceramics. The objective of this review is to provide a first understanding of the process as of today, with particular attention being paid on the underlying principles of the structure formation mechanisms and the influence of processing parameters on the structure. This analysis highlights the current limits of both the understanding and the control of the process. A few perspectives are given, with regards of the current achievements, interests and identified issues.

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Section: Applications Of Porous Freeze-casted Ceramicsmentioning

confidence: 99%

Freeze‐Casting of Porous Ceramics: A Review of Current Achievements and Issues

2008

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“…However, if the wall thickness of the ceramic detail is large enough and its shape is not too complex, it is possible to apply freeze casting even in the absence of polymer or hydrous silica. In this case, removal of ice from the frozen mold by sublimation becomes a necessary stage of the production technique [123,129,[140][141][142][143][144][145][146][147].…”

Section: Cryogel-derived Bulk Materialsmentioning

confidence: 99%

Inorganic Cryogels

Shlyakhtin¹

2014

Polymeric Cryogels

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“…Due to their favorable properties, the freeze-cast ceramics have been utilized as biocatalysts or biosensors, separation filters, gas distributors and insulators [15].…”

Section: Example 3: Highly Porous Drug Delivery Systems: Principles Omentioning

confidence: 99%

Design of Crystalline Solids

2009

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Product design is an active area of research. In a top-down approach to product design, the required product properties dictate product development from the very basic choice of the functional material to use for a defined task up to the processing required to render the material in a suitable form. This article focuses on processing crystalline solids with a particular field of application in mind and shows how process conditions can be used both to generate a material with particular properties and to tailor these properties. The examples selected are biased towards novel pharmaceutical applications; the principles of the processes and the resulting product properties discussed can, however, be transferred to other areas where materials with similar functions are required. The case studies presented pertain to in situ coating of solid particles (cases 1 and 2) with a crystalline coating of a different chemical nature, to freeze casting for generating porous particles and, finally, to the potential for exploiting phase transformations to generate tubular crystalline solids that can function as micro-delivery devices for other materials. Potential advantages of all four processing techniques are the delivery of well-defined products with tailored properties that can be controlled by judicious choice of the process conditions. Example 1: Forming and Coating the Solid Drug Simultaneously by Drop SolidificationAn in situ coating process [1][2][3] has the following prerequisites. The multi-component system from which the pastilles are formed must behave as a eutectic. For eutectic systems, one component can be isolated with a high degree of purity [4,5]. If a drop of this multi-component system is brought into contact with a colder environment, crystallization (nucleation and crystal growth) will commence on its surface [6]. If this drop is allowed to solidify in its entirety, the eutectic behavior ensures that the components are spatially separated. From this it follows that the higher-melting component, i.e., the component that crystallizes first, will preferentially accumulate on and near the surface of the pastille. As a consequence, the lower-melting components accumulate in the interior of the pastille. It is then conceivable that a eutectic mixture of an active pharmaceutical ingredient (drug substance) and a suitable coating material can be found that fulfils the above requirements. It then becomes possible to design and control the solidification in such a manner that a pastille is formed (see Fig. 1a) the exterior of which is predominantly composed of the coating material whereas the drug substance accumulates in the center of the pastille.In the following, the solidification of a drop of a binary melt will be described in detail. Matsuoka [7] summarized the binary solid-liquid equilibrium phase diagram types found in the International Critical Tables [8]. According to Matsuoka, it is

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Ice-mould freeze casting of porous ceramic components

Cited by 59 publications

References 16 publications

Freeze‐Casting of Porous Ceramics: A Review of Current Achievements and Issues

Freeze‐Casting of Porous Ceramics: A Review of Current Achievements and Issues

Inorganic Cryogels

Design of Crystalline Solids

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