Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells

Su, Yongsheng; Fan, Zhexiang; Xiao, Shan; Lin, Bojie; Miao, Yong; Liu, H.

doi:10.1111/ced.13043

Cited by 25 publications

(16 citation statements)

References 22 publications

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“…Besides, the protein-protein network results showed that the IGF1 strongly interacted with peripheral genes. Insulin-like growth factors (IGFs) prominently participated in hair follicle growth, including morphogenesis, proliferation and differentiation of cells, as well as regulation of the follicle growth cycle (Castela et al, 2017;Su et al, 2017). Previous research found that the deletion of insulin-like growth factor I receptors (IGF-IRs) in mice epidermis decreased epidermal thickness without affecting differentiation or apoptosis (Stachelscheid et al, 2008).…”

Section: T a B L E 2 The Population Informationmentioning

confidence: 99%

A gene co‐expression network analysis of the candidate genes and molecular pathways associated with feather follicle traits of chicken skin

Zhang

Liu

et al. 2020

J Animal Breeding Genetics

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Back and thigh skin of chickens showed significant differences in the thickness and the feather follicle density and size, which are important traits for slaughtered chickens' appearance. In the present study, global gene expression profiling was conducted in the back and thigh skin of chickens using Microarray technology. The results showed that 676 genes were differentially expressed between back and thigh skin. The expression of the differentially expressed genes (DEGs), including PPP1R3C, IGF1, PTCHD1, HOXB6, FGF9, CAMK4, SHH, BMP8B, FOXN1 and PTGER2, was validated by real‐time quantitative polymerase chain reaction (RT‐qPCR), and the results were consistent with microarray results. Functional analysis revealed that the DEGs were significantly involved in cell proliferation, differentiation, apoptosis, adhesion and transport process, and the pathways were significantly mapped into the ECM‐receptor interaction, peroxisome, focal adhesion, Hedgehog and PPAR signalling pathways. Protein–protein interaction network analysis suggested that signalling pathways related to feathers morphogenesis and development, such as Wnt, FGF, MAPK, SHH and BMP signalling pathways, occupied important positions in the network. Genes involved in these signalling pathways and adhesion molecules might play a vital role in skin and feather follicle development. Further single nucleotide polymorphism (SNP) association analysis of Wnt3A showed that the AC genotype of SNP g.255361 C>A significantly increased the feather follicle density of thigh skin. Our findings may provide new insights on candidate genes and pathways related to skin and feather follicle formation of chickens.

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Section: T a B L E 2 The Population Informationmentioning

confidence: 99%

A gene co‐expression network analysis of the candidate genes and molecular pathways associated with feather follicle traits of chicken skin

Zhang

Liu

et al. 2020

J Animal Breeding Genetics

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“…The research on herbs and active constituents as hair growth promoters has been driven by their less toxicity, easy availability, low‐cost, patient compliance and more than one mode of biochemical action . Specific effects of herbal extracts, polyherbal formulations, flavonoids and natural compounds on DPCs have been examined . In vivo hair growth promoting effects as proof of concept are also mentioned.…”

Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

102

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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“…Icariin is a major constituent of the plant Epimedium brevicornum (commonly known as barrenwort; member of the Family Berberidaceae), and has long been used in traditional Chinese medicine (TCM) in China. Previous studies from our team and other researchers have demonstrated that icariin has a wide range of pharmacological and biological properties, including anti‐inflammatory, antiosteoporotic and antiageing properties and promotion of hair growth activity . In addition, E. brevicornum was reported as being able to effectively increase the secretion of glucocorticoids in vivo .…”

Section: Introductionmentioning

confidence: 89%

Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus-pituitary-adrenal axis in vitro

et al. 2018

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Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells

Abstract: These results suggest that icariin can promote mouse hair follicle growth via stimulation of IGF-1 expression in DPCs.

Cited by 25 publications

References 22 publications

A gene co‐expression network analysis of the candidate genes and molecular pathways associated with feather follicle traits of chicken skin

A gene co‐expression network analysis of the candidate genes and molecular pathways associated with feather follicle traits of chicken skin

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth

Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus-pituitary-adrenal axis in vitro

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