Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis

Wei, Chen; Ping, Dai Qi; 范天佑,; Qiang, Chen Yong; Che, Tao

doi:10.1155/2016/9529630

Cited by 22 publications

(15 citation statements)

References 40 publications

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“…The data of Wei et al . indicated that icariin suppressed articular bone loss and prevented joint destruction in rheumatoid arthritis [43]. In this study, we confirmed that PLGA/icariin scaffolds had good biocompatibility during in vitro experiments.…”

Section: Discussionsupporting

confidence: 81%

PLGA scaffold carrying icariin to inhibit the progression of osteoarthritis in rabbits

Zhao

et al. 2019

R. Soc. open sci.

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Icariin, the main effective component extracted from epimedium, has been shown to stimulate osteogenic differentiation and bone formation and to increase synthesis of the cartilage extracellular matrix. However, there has been little study on the effects of icariin on osteoarthritis. In this study, we loaded icariin onto poly(lactic-co-glycolic acid) (PLGA) electrospinning. The aim of this study was to explore a composite scaffold and to inhibit the progression of osteoarthritis. Our main experimental results demonstrated that the PLGA/icariin composite spinning scaffold had higher hydrophilicity, and icariin was released slowly and steadily from the scaffold. According to the results of an MTT test, immunofluorescence staining, an alkaline phosphate activating assay and a real-time polymerase chain reaction (RT-PCR) assay, the PLGA/icariin composite scaffold had good biocompatibility. In models of osteoarthritis, the results of a RT-PCR assay indicated that the PLGA/icariin scaffold promoted the synthesis of the extracellular matrix. The results of X-ray microtomography and histological evaluation demonstrated that the PLGA/icariin scaffold maintained the functional morphology of articular cartilage and inhibited the resorption of subchondral bone trabeculae. These findings indicated that the PLGA and icariin composite scaffold has therapeutic potential for use in the treatment of osteoarthritis.

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Section: Discussionsupporting

confidence: 81%

PLGA scaffold carrying icariin to inhibit the progression of osteoarthritis in rabbits

Zhao

et al. 2019

R. Soc. open sci.

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“…EGCG protected ΔΨ m level against oxidative stress and acted as a pro-survival agent in NP cells via activation of PI3K/Akt signaling pathway [95]. Icariin, isolated from herba epimedii or horny goat weed, is a bioactive and peroxylated flavonol glycoside compound, which has been studied for the treatment of degenerative diseases of articular cartilage [96]. Icariin's anti-oxidative and mitochondrial protective effects are attributed to the activation of PI3K/Akt and Nrf2 signaling pathways, resulting in ΔΨ m restoration, decrease of ROS production, and apoptosis in NP cells [96,97].…”

Section: Flavonoidsmentioning

confidence: 99%

“…Icariin, isolated from herba epimedii or horny goat weed, is a bioactive and peroxylated flavonol glycoside compound, which has been studied for the treatment of degenerative diseases of articular cartilage [ 96 ]. Icariin’s anti-oxidative and mitochondrial protective effects are attributed to the activation of PI3K/Akt and Nrf2 signaling pathways, resulting in ∆Ψ m restoration, decrease of ROS production, and apoptosis in NP cells [ 96 , 97 ]. Furthermore, it was supposed a probable cross talk between Nrf2 and PI3K/Akt for attenuating the mitochondrial damage and preserving the cellular redox homeostasis [ 97 ].…”

Section: Small Molecules Targeting Mitochondrial Dysfunction In Ivd Degenerationmentioning

confidence: 99%

Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration

2021

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The prevalence of rheumatic and musculoskeletal diseases (RMDs) including osteoarthritis (OA) and low back pain (LBP) in aging societies present significant cost burdens to health and social care systems. Intervertebral disc (IVD) degeneration, which is characterized by disc dehydration, anatomical alterations, and extensive changes in extracellular matrix (ECM) composition, is an important contributor to LBP. IVD cell homeostasis can be disrupted by mitochondrial dysfunction. Mitochondria are the main source of energy supply in IVD cells and a major contributor to the production of reactive oxygen species (ROS). Therefore, mitochondria represent a double-edged sword in IVD cells. Mitochondrial dysfunction results in oxidative stress, cell death, and premature cell senescence, which are all implicated in IVD degeneration. Considering the importance of optimal mitochondrial function for the preservation of IVD cell homeostasis, extensive studies have been done in recent years to evaluate the efficacy of small molecules targeting mitochondrial dysfunction. In this article, we review the pathogenesis of mitochondrial dysfunction, aiming to highlight the role of small molecules and a selected number of biological growth factors that regulate mitochondrial function and maintain IVD cell homeostasis. Furthermore, molecules that target mitochondria and their mechanisms of action and potential for IVD regeneration are identified. Finally, we discuss mitophagy as a key mediator of many cellular events and the small molecules regulating its function.

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“…The treatment of osteoporosis is still a challenge [15]. Icariin is an herbal substance extracted from the plant Epimedium, which has antiosteoporotic and anti-osteoarthritic effects [3][4][5][6][7], and promotes bone healing [16]. Several studies have suggested that icariin not only increases the osteogenic differentiation of bone mesenchymal stem cells [17][18][19], but also inhibits osteoclast differentiation [20].…”

Section: Discussionmentioning

confidence: 99%

“…Icariin is a natural substance extracted from the herb Epimedium. Icariin has anti-osteoporotic and antiosteoarthritic effects [3][4][5][6][7], through promoting osteoblastogenesis, and suppressing osteoclastogenesis [8]. However, the mechanisms underlying its antiosteoporotic action are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

The shared KEGG pathways between icariin-targeted genes and osteoporosis

Xiong

Luu

et al. 2020

Aging

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Osteoporosis is a common metabolic bone disease that affects about 40% of postmenopausal women. Treatment options for osteoporosis are limited, however. Icariin is an herbal substance that has been shown to improve bone mass, but the mechanisms are largely unknown. Using bioinformatics analysis, we have identified the hub genes and KEGG pathways shared between icariin-targeted genes and osteoporosis. The top five shared KEGG pathways were the Toll-like receptor signaling pathway, adipocytokine pathway, neurotrophin signaling pathway, NOD-like receptor signaling, and B cell receptor signaling pathway; the hub genes were RELA, NFKBIA, and IKBKB, belonging to the NF-κB family. The identified icariin-targeted genes are involved in inflammation, insulin resistance, apoptosis, and immune responses, and regulate the PI3K-Akt, NF-κB, MAPK, and JNK signaling pathways. Our in vitro data show that icariin inhibits apoptosis in human mesenchymal stem cells by suppressing JNK/c-Jun signaling pathway. Together, these findings indicate that icariin exerts its anti-osteoporotic function by inhibiting JNK/c-Jun signaling pathway, and suggest that icariin may be a promising treatment option for osteoporosis.

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Icariin Prevents Cartilage and Bone Degradation in Experimental Models of Arthritis

Cited by 22 publications

References 40 publications

PLGA scaffold carrying icariin to inhibit the progression of osteoarthritis in rabbits

PLGA scaffold carrying icariin to inhibit the progression of osteoarthritis in rabbits

Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration

The shared KEGG pathways between icariin-targeted genes and osteoporosis

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