Ibuprofen Pretreatment Inhibits Prostacyclin Release during Abdominal Exploration in Aortic Surgery

Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines

“…As previously reported e. g. by Brinkmann et al [1], Seeling et al [3] and Hudson et al [4] most of the significant results were found within 15 min after eventeration, when haemodynamic reactions and/or shunt perfusion and/or flush were most pronounced [1,3,4]. Interestingly Seeling et al [3], who only found significant differences in the decrease of paO 2 before and after eventration used promethazine, a potent H 1 and H 2 antagonist [15] as part of the premedication Vol.…”

“…at 20 min after eventration since cross clamping of the abdominal aorta followed. These times were chosen partially as they had previously been used in other studies [1,3,4,17]. But also according to the absorption-elimination-kinetics (Bateman function) of plasma histamine [12,13].…”

“…The syndrome occurs after laparotomy, when the surgeon begins abdominal exploration and traction of the small intestine. In addition to prostacyclin liberation [3,4], eventration of the small intestine may also cause histamine release from mesenteric mast cells [5]. Histamine is the main mediator responsible for cardiovascular disturbances during anaesthesia and surgery [6].…”

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“…The placebo group also developed late increases in levels of thromboxane B 2. The authors of the study concluded thromboxane B 2 to be a counter regulatory mechanism to the vasodilatory effects of PGI 2 [9]. This study demonstrated that COX inhibitors could help in the prevention of MTS.…”

“…As previously mentioned, multiple studies have shown the incidence of mesenteric traction syndrome can be largely reduced by pretreatment with non-selective COX inhibitors [9,13,16].…”