Ibuprofen-loaded chitosan and chemically modified chitosans—Release features from tablet and film forms

Thermodynamic Changes Induced by Intermolecular Interaction Between Ibuprofen and Chitosan: Effect on Crystal Habit, Solubility and In Vitro Release Kinetics of Ibuprofen

“…CT was used in this study because of its abundant natural occurrence, ability to form polyelectrolyte complexes, biocompatibility, low toxicity, good mechanical properties and long resident times at the site of application (10). Biodegradable polyelectrolyte nanocarriers such as nanoparticles, nanocapsules, micellar systems, and nanoconjugates have been the focus of intensive research for the delivery of poorly soluble drugs because they provide great opportunities in the area of controlled drug release and site specific drug delivery due to their submicron size (11,12).…”

Preparation, characterization, antibacterial properties, and hemostatic evaluation of ibuprofen‐loaded chitosan/gelatin composite films

“…An ideal wound dressing should be nontoxic, nonallergenic, and nonadherent to the skin; can absorb excess exudates from the wound to maintain a moist healing environment; and displays better antibacterial activity . Furthermore, loading of chitosan or one of its chemical derivatives might provide these advantages for nonsteroidal anti‐inflammatory drugs such as ibuprofen . The present study has reported the development of CS biopolymer derivatives in controlling the release of nonsteroidal drugs.…”

“…The present study has reported the development of CS biopolymer derivatives in controlling the release of nonsteroidal drugs. The drug loading matrix was prepared in crosslinked film and tablet forms, to accommodate the selected drug ibuprofen inside the polymeric material …”

Curcumin/cellulose micro crystals/chitosan films: Water absorption behavior and in vitro cytotoxicity

“…The samples were designated as Ch/CMC(0) 0. 18 and Ch/CMC (20) 0. 18 where the samples carry their usual meaning and the sub-script is the amount of CC in g loaded in the film.…”

“…Therefore, in place of GTA, other cross linkers such as genipin [15], suberoyl chloride [16] epichlorohydrin [17] etc. have also been used, but they are also reported to be toxic for human [18]. With the aim to fabricate un-cross linked chitosan film, but with controllable physical and chemical properties, we have dispersed cellulose micro crystals uniformly into chitosan film using a novel VIPI approach.…”