Ibuprofen inhibits pyrogen-dependent expression of VCAM-1 and ICAM-1 on human endothelial cells

Kapiotis, Stylianos; Sengoelge, Gürkan; Sperr, Wolfgang R.; Baghestanian, Mehrdad; Quehenberger, Peter; Bevec, Dorian; Li, S.R.; Menzel, E. J.; Mühl, Adolf; D, Zapolska; Virgolini, Irene; Valent, Peter; Speiser, Wolfgang

doi:10.1016/0024-3205(96)00210-x

Cited by 56 publications

(28 citation statements)

References 46 publications

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“…However, there are several contradictory reports on the role of COX and prostaglandins in ICAM-1 expression. NSAIDs such as ibuprofen and aspirin inhibits cytokineinduced expression of adhesion molecules including VCAM-1 and ICAM-1 in human endothelial cells and synovial fibroblasts (Kapiotis et al, 1996;Sakurada et al, 1996). In contrast, COX-2 and PGE 2 down-regulates ICAM-1 expression in IL-1␤-stimulated human vascular smooth muscle cells and gingival fibroblasts (BishopBailey et al, 1998;Noguchi et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells

et al. 2006

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Section: Discussionmentioning

confidence: 99%

COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells

et al. 2006

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“…The anti-inflammatory agent ibuprofen can inhibit leukocyte-endothelial adhesion through suppression of IL-1␣-and TNF-␣-induced expression of VCAM-1 and ICAM-1. 111,112 Administration of ibuprofen by means of a locally implanted slow-release copolymer in a model of vasospasm in the femoral artery of rats significantly reduced vasospasm at 12 days if treatment was started within 6 hours after blood exposure. 102 Treatment also resulted in decreased endothelial transmigration of leukocytes, inferred from significantly reduced periadventitial leukocyte counts.…”

Section: Inflammatory Adhesion Moleculesmentioning

confidence: 99%

Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease

Frijns

Kappelle

2002

Stroke

349

264

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Background — In this review we discuss the role of inflammatory cell adhesion molecules (CAMs) in ischemic stroke and in delayed cerebral ischemia after subarachnoid hemorrhage. Vascular endothelial cells and leukocytes express several inflammatory adhesion receptors, the most important of which are the selectins, immunoglobulin gene superfamily CAMs, and β2 integrins. They mediate the transmigration process of leukocytes to the abluminal side of the endothelium. Summary of Review — There is ample evidence from animal models of middle cerebral artery occlusion that expression of CAMs is associated with cerebral infarct size. Absence of CAMs in knockout animals resulted in reduced infarct size. When middle cerebral artery occlusion in experimental stroke was followed by reperfusion, administration of anti-CAM antibodies decreased infarct size. Thus far, anti-CAM treatment has not been successful in patients with ischemic stroke. Inflammatory CAM may also play a role in the pathogenesis of delayed cerebral ischemia after subarachnoid hemorrhage. In animal models, increased expression of CAMs has been observed in vasospastic arteries. Increased concentrations of CAMs have also been found in cerebrospinal fluid of patients with subarachnoid hemorrhage. Conclusions — Further research on the role of inflammatory CAMs in the pathogenesis of ischemic cerebrovascular disorders should lead to new diagnostic and therapeutic strategies.

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“…Human umbilical vascular endothelial cells (HUVECs) were isolated from umbilical veins by using collagenase type IA according to a standard protocol. 17 HUVECs were cultured to confluence in endothelial basal medium containing 10% FCS and passaged 2 times. To assess chemokine/cytokine release, HUVECs were cultured in 6-well plates and incubated with various concentrations of statins (0.1 to 50 mol/L) in RPMI 1640 medium for 12 or 24 hours.…”

Section: Isolation and Culture Of Primary Huvecsmentioning

confidence: 99%

Simvastatin Reduces Expression of Cytokines Interleukin-6, Interleukin-8, and Monocyte Chemoattractant Protein-1 in Circulating Monocytes From Hypercholesterolemic Patients

Rezaie-Majd

Maca

Bucek

et al. 2002

ATVB

337

218

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Objective-A number of studies have shown that statins decrease morbidity and mortality in patients with cardiovascular diseases. The anti-inflammatory effects of statins have recently been implicated in the clinical benefit that can be obtained in the treatment of atherosclerosis. Little is known about the mechanisms by which statins counteract inflammation. Methods and Results-In this study, we asked whether simvastatin can influence in vitro and in vivo production of the proinflammatory cytokines interleukin (IL)-6, IL-8, and monocyte chemoattractant protein-1. A total of 107 hypercholesterolemic patients were treated with simvastatin. As measured by ELISA, serum levels of cytokines significantly decreased after 6 weeks of treatment (PϽ0.05).

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Ibuprofen inhibits pyrogen-dependent expression of VCAM-1 and ICAM-1 on human endothelial cells

Cited by 56 publications

References 46 publications

COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells

COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells

Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease

Simvastatin Reduces Expression of Cytokines Interleukin-6, Interleukin-8, and Monocyte Chemoattractant Protein-1 in Circulating Monocytes From Hypercholesterolemic Patients

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