“…recent PNAS study by Baker et al might get integrated with their own single-cell transcriptomics data from fly brains exposed to cocaine (16), or the aforementioned human postmortem study (15), or even future human GWAS findings with larger samples of cocaine users. Either way, Drosophila remains a useful model organism in the study of complex disorders, because of their economy of scale in both hypothesis generation, be that via GWASs (2), or transcriptomics (16), as well as in hypothesis testing of candidate genes and SNPs (2) and therapeutic interventions (15). Neuropsychiatric disorders such as addiction are complex in their etiology, and the integration of many approaches, including model organisms, promises to get us closer to an understanding of what drives individuals from an initial drug experience to an obsessed-over preoccupation.…”