From single flies to many genes: Using
            <i>Drosophila</i>
            to explore the genetics of psychostimulant consumption

Titos, Iris; Rothenfluh, Adrian

doi:10.1073/pnas.2109994118

Cited by 1 publication

(2 citation statements)

References 18 publications

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“…For instance, medical investigations reported significant associations between drug abuse and maternal and fetal morbidity 63 , while recent family studies suggest an important inherited predisposition driving the variability to drug response and addiction 32,33 . Taken together, our results suggest that the detection of subtle but significant shifts in allele frequencies of genes implicated in alkaloids metabolism could likely be related to their fitness value in the Central Andean region where humans have been consuming San Pedro cacti for millennia.…”

Section: Discussionmentioning

confidence: 99%

“…Third, we acknowledge that many human orthologs of our candidate genes might not be shared across our studied datasets, resulting in the underestimation of the number of genes. Indeed, recent comparative studies of flies and humans recognize that the overall low number of reported genes associated to drug response, is likely due to the current low representation of human studies 33 . This is especially critical in our case, as the reduced genotyping effort of South American Native communities implied a limited sampling for both our target and reference populations 83,84 .…”

Section: Considerations and Caveats Elucidating The Antiquity And Ext...mentioning

confidence: 99%

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Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti

Padró

Panis

Luisi

et al. 2022

Sci Rep

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Cultural transformations of lifestyles and dietary practices have been key drivers of human evolution. However, while most of the evidence of genomic adaptations is related to the hunter-gatherer transition to agricultural societies, little is known on the influence of other major cultural manifestations. Shamanism is considered the oldest religion that predominated throughout most of human prehistory and still prevails in many indigenous populations. Several lines of evidence from ethno-archeological studies have demonstrated the continuity and importance of psychoactive plants in South American cultures. However, despite the well-known importance of secondary metabolites in human health, little is known about its role in the evolution of ethnic differences. Herein, we identified candidate genes of adaptation to hallucinogenic cactus in Native Andean populations with a long history of shamanic practices. We used genome-wide expression data from the cactophilic fly Drosophila buzzatii exposed to a hallucinogenic columnar cactus, also consumed by humans, to identify ortholog genes exhibiting adaptive footprints of alkaloid tolerance. Genomic analyses in human populations revealed a suite of ortholog genes evolving under recent positive selection in indigenous populations of the Central Andes. Our results provide evidence of selection in genetic variants related to alkaloids toxicity, xenobiotic metabolism, and neuronal plasticity in Aymara and Quechua populations, suggesting a possible process of gene-culture coevolution driven by religious practices.

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Section: Discussionmentioning

confidence: 99%

Section: Considerations and Caveats Elucidating The Antiquity And Ext...mentioning

confidence: 99%

Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti

Padró

Panis

Luisi

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

From single flies to many genes: Using Drosophila to explore the genetics of psychostimulant consumption

Cited by 1 publication

References 18 publications

Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti

Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti

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