Ibozol, a new diterpenoid from Iboza riparia

Zelnik, R.; Rabenhorst, Ema; Matida, Amabile K.; Gottlieb, Hugo E.; Lavie, David; Panizza, Silvio

doi:10.1016/s0031-9422(00)88701-4

Cited by 38 publications

(22 citation statements)

References 8 publications

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“…fenchone, tetradenolide and umuravumbolide (Campbell et al, 1997;Sabitha et al, 2012; Van Puyvelde and de Kimpe, 1998) and terpenoids viz. terpineol, fenchol, perillyl alcohol, caryophyllene and ibozol (Campbell et al, 1997;Zelnik et al, 1978). Mukunthan and Balaji (2012) reported that nanoparticle characteristics can be influenced by extracts arising from different sources as they comprise different concentrations and combinations of organic reducing agents.…”

Section: Edx Analysismentioning

confidence: 99%

Green synthesis of nano-silver particles from leaf and stem extracts of Iboza (Tetradenia riparia)

Shaik¹,

Mkize²,

Khumalo³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Secondary metabolites derived from plant extracts can be used in the reduction of metal salts into their respective nanoparticles using simple, environmentally friendly and cost effective green synthesis techniques. Metal nanoparticles have important applications in medicine and agriculture. The leaves of Tetradenia riparia (Iboza), an important medicinal species in South Africa, are reported to contain various terpenoids and pyrones which can be used in the reduction of silver nitrate (AgNO 3 ) to nano-silver particles. Materials and Methods: Fresh leaves and stems of Iboza were oven-dried, crushed, extracted in water and methanol and filtered followed by incubation with AgNO 3 . Synthesized nano-silver particles were characterised using ultraviolet visible (UV-Vis) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy and Fourier transform infrared (FTIR) spectroscopy. Results:The bio-reduction of metal ion to base metal was rapidly conducted in a single step and at room temperature and pressure. UV-Vis spectra showed the characteristic surface plasmon resonance band of the synthesized nano-silver particles at 410 nm for all extracts. SEM analysis revealed predominantly aggregated spherically-shaped nano-silver particles with a size range of 20-50 nm and an average diameter of 26 nm. The presence of elemental silver in the nanoparticles was confirmed by EDX at 3 keV. As revealed by FTIR analysis, the reducing agents included terpenoids and pyrones which were responsible for reducing and capping the nano-silver particles. Conclusion: Both methanol and aqueous-derived extracts of Iboza leaves and stems can be used to synthesize nano-silver particles. FTIR evidence suggests that the reduction of the silver ions and the synthesis of the nanoparticles may have been actioned by various terpenoid and pyrone compounds found in the plant parts.

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Section: Edx Analysismentioning

confidence: 99%

Green synthesis of nano-silver particles from leaf and stem extracts of Iboza (Tetradenia riparia)

Shaik¹,

Mkize²,

Khumalo³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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“…This exotic plant is popularly known as false myrrh, lemon verbena, lavandula, misty plume, or incense. In Brazil, T. riparia was introduced as an exotic ornamental plant and is cultivated in parks, gardens, homes, and botanical gardens where it releases a very intense and pleasant aroma [6].…”

Section: Introductionmentioning

confidence: 99%

“…From the essential oil of T. riparia, Zelnik et al [6] isolated ibozol and 7α-hydroxyroyleanone, Van Puyvelde et al [4,9] isolated diterpenediol 8 (14),15-sandaracopimaradiene-7α,18-diol, and 1',2'-dideacetylboronolide. The compounds 8 (14),15-sandaracopimaradiene-2α,18-diol, a diterpenod with antimicrobial activity [5], 5,6-dehydro-α-pyrone (umuravumbolide) [10] and tetradenolide α-pyrone [5] have also been isolated.…”

Section: Introductionmentioning

confidence: 99%

New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities

et al. 2014

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Tetradenia riparia (Hochstetter) Codd belongs to the Lamiaceae family and it was introduced in Brazil as an exotic ornamental plant. A previous study showed its antimicrobial, acaricidal and analgesic activities. Two compounds were isolated from essential oil of T. riparia leaves and identified as 9β,13β-epoxy-7-abietene (1), a new one, OPEN ACCESSMolecules 2014, 19 515 and 6,7-dehydroroyleanone (2), already reported for another plant. The structure of these compounds was determined by spectroscopic analysis and by comparison with literature data. The cytotoxic activities of the essential oil and compounds 1 and 2 were determined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and by tumor cells MDA-MB-435 (human breast carcinoma), HCT-8 (human colon), SF-295 (human nervous system) and HL-60 (human promyelocytic leukemia). The essential oil and compound 1 showed high cytotoxic potential of the cell lines SF-295 (78.06% and 94.80%, respectively), HCT-8 (85.00% and 86.54%, respectively) and MDA-MB-435 (59.48% and 45.43%, respectively). Compound 2 had no cytotoxic activity. The antioxidant activity was determined by 2,2-diphenyl-1-picryl-hydrazyl (DPPH), β-carotene-linoleic acid system and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The inhibitory concentration (IC 50 in µg mL −1 ) for essential oil and compound 2 was, respectively 15.63 and 0.01 for DPPH; 130.1 and 109.6 for β-carotenelinoleic acid and 1524 and 1024 for ABTS. Compound 1 had no antioxidant activity. By fractioning the oil, it was possible to identify two unpublished compounds: 1 with high cytotoxic potential and 2 with high antioxidant potential.

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“…In South Africa, the plant is found growing on wooded hillsides and stream banks of coastal KwaZulu-Natal, Mpumalanga and the Limpopo Provinces (Aubrey, 2001). Phytochemical studies of T. riparia reported the accumulation of essential oil in the leaves which is particularly rich in terpenes (Campbell et al, 1997), diterpenoids (de Kimpe et al, 1982;Van Puyvelde and de Kimpe, 1998;Zelnik et al, 1978) and a-pyrones (Van Puyvelde et al, 1979, 1981, 1986, 1987.…”

Section: Introductionmentioning

confidence: 99%

An investigation of the foliar trichomes of Tetradenia riparia (Hochst.) Codd [Lamiaceae]: An important medicinal plant of Southern Africa

Gairola

Naidoo

Bhatt

et al. 2009

Flora - Morphology, Distribution, Functional Ecology of Plants

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Ibozol, a new diterpenoid from Iboza riparia

Cited by 38 publications

References 8 publications

Green synthesis of nano-silver particles from leaf and stem extracts of <i>Iboza</i> (<i>Tetradenia riparia</i>)

Green synthesis of nano-silver particles from leaf and stem extracts of <i>Iboza</i> (<i>Tetradenia riparia</i>)

New Natural Diterpene-Type Abietane from Tetradenia riparia Essential Oil with Cytotoxic and Antioxidant Activities

An investigation of the foliar trichomes of Tetradenia riparia (Hochst.) Codd [Lamiaceae]: An important medicinal plant of Southern Africa

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