Abstract:A 73-year-old female patient presented for mitral valve replacement and coronary artery bypass grafting secondary to multivessel coronary disease and severe mitral valve regurgitation with moderate stenosis. After bypass, the patient developed refractory hypotension with decreased biventricular volume and elevated central venous pressure (CVP). Transesophageal echocardiography (TEE) was utilized to make the diagnosis of acute intraoperative superior vena cava (SVC) syndrome. The SVC cannulation site was revise… Show more
“…Thrombi associated with these catheters and parts of implanted devices (e.g., pacemaker leads) have emerged as a significant cause of SVCS and account for up to 30% of all cases [6,7]. Additional rare benign non-device-related causes of SVCS include mediastinal fibrosis, radiation fibrosis, retrosternal goiter, Bechet's syndrome, and iatrogenic causes [18][19][20].…”
Superior vena cava syndrome (SVCS) is a clinical entity characterized by signs and symptoms arising from the obstruction or occlusion of the thin-walled superior vena cava (SVC) and can result in significant morbidity and mortality. Despite the rise of benign cases of SVCS, as a thrombotic complication of intravascular devices, it is most commonly seen secondary to malignancy as a consequence of thrombosis, direct invasion of tumor cells inside the vessel, or external compression. SVCS can be the initial presentation of a previously undiagnosed tumor in up to 60% of cases. Lung cancer and non-Hodgkin lymphoma (NHL) are responsible for up to 85%-90% of malignancy-related SVCS, while metastatic cancers account for approximately 10%. Herein, we review the pathophysiology, etiology, clinical presentation, diagnosis, and management of malignancy-related SVCS.
“…Thrombi associated with these catheters and parts of implanted devices (e.g., pacemaker leads) have emerged as a significant cause of SVCS and account for up to 30% of all cases [6,7]. Additional rare benign non-device-related causes of SVCS include mediastinal fibrosis, radiation fibrosis, retrosternal goiter, Bechet's syndrome, and iatrogenic causes [18][19][20].…”
Superior vena cava syndrome (SVCS) is a clinical entity characterized by signs and symptoms arising from the obstruction or occlusion of the thin-walled superior vena cava (SVC) and can result in significant morbidity and mortality. Despite the rise of benign cases of SVCS, as a thrombotic complication of intravascular devices, it is most commonly seen secondary to malignancy as a consequence of thrombosis, direct invasion of tumor cells inside the vessel, or external compression. SVCS can be the initial presentation of a previously undiagnosed tumor in up to 60% of cases. Lung cancer and non-Hodgkin lymphoma (NHL) are responsible for up to 85%-90% of malignancy-related SVCS, while metastatic cancers account for approximately 10%. Herein, we review the pathophysiology, etiology, clinical presentation, diagnosis, and management of malignancy-related SVCS.
“…The superior vena cava syndrome is an infrequent presentation and thus can be easily missed [1]. The most common sources of SVCS include clot formation that leads to obstruction of blood flow returning to the heart [6]. The increasing use of central catheters and pacemaker wires in the past few decades has led to an increase in the cases of clot formation [6,7].…”
Section: Discussionmentioning
confidence: 99%
“…The most common sources of SVCS include clot formation that leads to obstruction of blood flow returning to the heart [6]. The increasing use of central catheters and pacemaker wires in the past few decades has led to an increase in the cases of clot formation [6,7]. The management of SVCS must be according to the underlying etiology.…”
“…The execution of intraoperative TEE is particularly challenging due to the poor hemodynamic status of patients undergoing surgery. Various intraoperative parameters significantly influence the TEE assessment of numerous cardiac lesions, especially in determining the degree of valvular regurgitation [5]. These parameters include preload variability (affected by intravascular volume status, vasodilator treatment, and general anesthesia factors), afterload variability (influenced by vasopressor and inotropic treatments, vasodilator therapy, the presence of an intra-aortic balloon pump, LVOT (left ventricular outflow tract) obstruction, and other anesthesia-related factors), as well as the presence of arrhythmias and myocardial function, which can vary post hypothermia or following cardioplegic solution administration [6].…”
Background and Objectives: Transesophageal echocardiography (TEE) is considered an indispensable tool for perioperative evaluation in mitral valve (MV) surgery. TEE is routinely performed by anesthesiologists competent in TEE; however, in certain situations, the expertise of a senior cardiologist specializing in TEE is required, which incurs additional costs. The purpose of this study is to determine the indications for specialized perioperative TEE based on its utility and the correlation between intraoperative TEE diagnoses and surgical findings, compared with routine TEE performed by an anesthesiologist. Materials and Methods: We conducted a three-year prospective study involving 499 patients with MV disease undergoing cardiac surgery. Patients underwent intraoperative and early postoperative TEE and at least one other perioperative echocardiographic evaluation. A computer application was dedicated to calculating the utility of each type of specialized TEE indication depending on the type of MV disease and surgical intervention. Results: The indications for performing specialized perioperative TEE identified in our study can be categorized into three groups: standard, relative, and uncertain. Standard indications for specialized intraoperative TEE included establishing the mechanism and severity of MR (mitral regurgitation), guiding MV valvuloplasty, diagnosing associated valvular lesions post MVR (mitral valve replacement), routine evaluations in triple-valve replacements, and identifying the causes of acute, intraoperative, life-threatening hemodynamic dysfunction. Early postoperative specialized TEE in the intensive care unit (ICU) is indicated for the suspicion of pericardial or pleural effusions, establishing the etiology of acute hemodynamic dysfunction, and assessing the severity of residual MR post valvuloplasty. Conclusions: Perioperative TEE in MV surgery can generally be performed by a trained anesthesiologist for standard measurements and evaluations. In certain cases, however, a specialized TEE examination by a trained senior cardiologist is necessary, as it is indirectly associated with a decrease in postoperative complications and early postoperative mortality rates, as well as an improvement in immediate and long-term prognoses. Also, for standard indications, the correlation between surgical and TEE diagnoses was superior when specialized TEE was used.
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