Iatrogenic gallbladder perforation during laparoscopic cholecystectomy and outcomes: a systematic review and meta-analysis

Evans, Louis; Sams, Emily; Naguib, Andrew; Hajibandeh, Shahin; Hajibandeh, Shahab

doi:10.1007/s00423-022-02439-2

Cited by 8 publications

(9 citation statements)

References 23 publications

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“…In some previous reports, IGP during LC did not increase the risk of wound infection and postoperative collection [8,9,[17][18][19]. On the other hand, this study shows that patients with IGP had a higher frequency of infectious complications than did those without IGP (data not shown).…”

Section: Discussioncontrasting

confidence: 37%

“…In the period January 2013 through Apr 2021, 539 patients underwent LC at the Department of Gastroenterological Surgery, Kinan Hospital, Japan. The patients who received emergency surgeries due to acute cholecystitis (n = 64), conversion to open surgeries (n = 10), combined resections (n = 19), or any intraoperative complications except IGP (n = 5) were excluded from this study. Patients without IGP during surgeries were also excluded (n = 320).…”

Section: Patientsmentioning

confidence: 99%

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Management of iatrogenic gallbladder perforation during laparoscopic cholecystectomy

Urakawa

Michiura

Tokuyama

et al. 2023

Preprint

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Purpose Iatrogenic gallbladder perforation frequently occurs during laparoscopic cholecystectomy and may increase the risk of infectious complications. The effectiveness of postoperative antibiotics and drainage in preventing infections remain unclear. The study aimed to investigate the clinical outcomes of patients with Iatrogenic gallbladder perforation during laparoscopic cholecystectomy in relation to these treatments.Methods One hundred twenty-one consecutive patients with Iatrogenic gallbladder perforation during laparoscopic cholecystectomy were enrolled. Surgeons chose the treatments for Iatrogenic gallbladder perforation: antibiotics (n = 48), drainage (n = 39), and no treatment (n = 34). Infectious complications were classified into wound infections, intra-abdominal abscesses, distant infections, and infections with unknown origin.Results The drainage group showed a nonsignificantly higher frequency of overall infectious complications than the other two groups (antibiotics vs. drainage vs. no-treatment = 14.6% vs. 23.1% vs. 11.8%, P = 0.31). The infection-positive group (n = 20) had a higher frequency of diabetes mellitus (positive vs. negative group = 52.6% vs. 17.7%, P = 0.0009) and lower preoperative albumin (3.8 vs. 4.1 g/dL, P = 0.0081) than the infection-negatve group. Multivariate analysis showed that a lower preoperative albumin (OR 4.90, 95% CI 1.20–20.0, P = 0.027) and the presence of diabetes mellitus (OR 5.49, 95% CI 1.62–18.6, P = 0.0063) were independent factors of overall infectious complications.Conclusions Additional treatments such as postoperative antibiotics and drainage may be unnecessary to prevent infectious complications in patients with Iatrogenic gallbladder perforation during laparoscopic cholecystectomy. diabetes mellitus and malnutrition were associated with postoperative infections. These findings should be validated in larger independent samples.

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Section: Discussioncontrasting

confidence: 37%

Section: Patientsmentioning

confidence: 99%

Management of iatrogenic gallbladder perforation during laparoscopic cholecystectomy

Urakawa

Michiura

Tokuyama

et al. 2023

Preprint

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“…Similarly, Evans et al [29] reported that GB perforation mostly caused by various risk factors such as increased obesity, male gender, advancement of age, upper right abdomen adhesion, preoperative palpable GB, acute cholecystitis, and pain lasted for more than 96 hours. Of these parameters, an individual's age is the most critical factor that contributed to GB perforation.…”

Section: Discussionmentioning

confidence: 95%

Incidence, Risk Factors and Outcome of Gallbladder Perforation during Laparoscopic Cholecystectomy

Ahmed¹,

Khan²,

Ahmad³

et al. 2022

PJMHS

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Background and Aim: Gallbladder perforation has been recorded in patients undergoing laparoscopic cholecystectomy and associated with the development of gallstones and bile leakage. The present study investigated the incidence, risk factors, and outcome of gallbladder perforation in patients undergoing elective laparoscopic cholecystectomy. Patients and Methods: This prospective study was conducted on 156 patients who underwent laparoscopic cholecystectomy in the department of General Surgery, Federal Government Polyclinic Hospital, Islamabad from January 2021 to July 2022. Gallbladder stone patients with chronic symptoms such as vomiting, recurrent episodes of epigastric, nausea, and hypochondrial pain on right side were included. Acute cholecystitis patients with single or multiple gallstone disease were also enrolled. All the patients were prepared for laparoscopic cholecystectomy and investigations such as blood sugar, liver function test, CBC, blood urea and creatinine, ultrasound of gallbladder, and ECG were done. SPSS version 26 was used for data analysis. Results: Of the total 156 patients, there were 126 (80.8%) females and 30 (19.2%) male. Age-wise distribution of patients were as follows: 66 (42.3%) in 20-35 years, 52 (33.3%) in 36-50 years, and 38 (24.4%) in 51-65 years. The incidence of single gall stone (SGS), multi gallstones (MGS), and acute cholecystitis was 48 (30.8%), 88 (56.4%), and 20 (12.8%) respectively. The overall mean age was 36 years. The incidence of gallbladder perforation was 26.9% (n=42) among all patients. Patients distribution based on gallbladder perforation were as follows: 17 (10.9%) in MGS, 14 (9.0%) in SGS, and 11 (7.1%) in acute cholecystitis cases. Conclusion: The present study found that the prevalence of gallbladder perforation was 26.9% among SGS, MGS, and acute cholecystitis. Majority of GB perforation occurred during gallbladder bed dissection. Acute cholecystitis patients are more prone to GB perforation. GB perforation can be reduced by utilization of harmonic scalpel in laparoscopic cholecystitis. Keywords: Elective laparoscopic cholecystectomy, Gallbladder perforation, Outcomes

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“…A perfuração iatrogênica da vesícula biliar, com extravasamento intracavitário de bile, esteve presente em 28,9% dos casos da nossa amostra, em taxa semelhante à descrita na literatura, entre 10 e 37% 26,27 . Esse achado está relacionado ao aumento no tempo operatório e no emprego de drenos 26 , além do tempo de internação hospitalar, porém sem impacto no risco de infecção de sítio cirúrgico ou coleções pós-operatórias 27 .…”

Section: Resultsunclassified

Câncer incidental de vesícula biliar: qual a prevalência e como operamos a colecistectomia por doença presumidamente benigna?

Silva

Veloso

Valadares

et al. 2022

Rev. Col. Bras. Cir.

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RESUMO Objetivos: determinar a prevalência de câncer incidental de vesícula biliar (CIVB) em colecistectomias realizadas em um hospital público terciário e descrever aspectos técnicos e epidemiológicos na realização de colecistectomias por doença presumidamente benigna. Método: estudo observacional descritivo, retrospectivo, a partir da análise de prontuários de pacientes submetidos à colecistectomia com hipótese pré-operatória de doença benigna entre janeiro de 2018 e janeiro de 2022. Resultados: a prevalência de adenocarcinoma de vesícula biliar na amostra avaliada foi de 0,16%, semelhante aos dados da literatura mundial. Os aspectos técnicos durante a realização da colecistectomia também foram descritos com frequência semelhante ao encontrado na literatura. Conclusão: o CIVB é uma doença rara mas de importância relevante na rotina do Cirurgião Geral. Seu diagnóstico, estadiamento e tratamento implicam diretamente no prognóstico. Aspectos técnicos durante a realização da colecistectomia nem sempre são lembrados pelos cirurgiões e podem interferir no prognóstico e tratamento subsequente do paciente.

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Iatrogenic gallbladder perforation during laparoscopic cholecystectomy and outcomes: a systematic review and meta-analysis

Cited by 8 publications

References 23 publications

Management of iatrogenic gallbladder perforation during laparoscopic cholecystectomy

Management of iatrogenic gallbladder perforation during laparoscopic cholecystectomy

Incidence, Risk Factors and Outcome of Gallbladder Perforation during Laparoscopic Cholecystectomy

Câncer incidental de vesícula biliar: qual a prevalência e como operamos a colecistectomia por doença presumidamente benigna?

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