Iatrogenic Effects of General Anesthesia in Children: Considerations in Treating Large Congenital Nevocytic Nevi

Backman, Margaret E.; Kopf, Alfred W.

doi:10.1111/j.1524-4725.1986.tb01921.x

Cited by 25 publications

(9 citation statements)

References 18 publications

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“…Particularly, it is crucial to establish when synaptogenesis in the human brain is at its peak, as the vulnerability of mammalian brains to apoptotic neuronal damage coincides with the peak of neuronal development [8,15]. As of now, only a handful of retrospective studies have reported regressive behavioral changes in children exposed to general anesthesia, indicating that the most vulnerable age group is younger than 4 years [31][32][33][34][35]. A causal relationship between a specific anesthesia protocol and specific cognitive disturbances has never been reported.…”

Section: Resultsmentioning

confidence: 99%

Anesthesia and the developing brain

Jevtović-Todorović¹

2011

Current Opinion in Anaesthesiology

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Although clinical importance remains to be substantiated, results to date do indicate that exposure of animals to general anesthesia during active synaptogenesis is most detrimental. Accordingly, it is essential to determine when synaptogenesis begins and ends in developing humans. It is also imperative that effective preventive techniques be developed so that existing anesthetics can be used with minimum risk of neurotoxic side-effects of anesthesia.

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Section: Resultsmentioning

confidence: 99%

Anesthesia and the developing brain

Jevtović-Todorović¹

2011

Current Opinion in Anaesthesiology

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“…Until further information regarding the risk of melanoma in LCNN is gained from prospective studies such as this, we continue to recommend total surgical excision of LCNN when feasihie. This should he done after full explanation of the benefits and risks of the operative procedure required, and at a time in life when the psychologic trauma is least (25).…”

Section: Resultsmentioning

confidence: 99%

Melanomas Arising in Large Congenital Nevocytic Nevi: A Prospective Study

Gari

Rivers

Kopf³

1988

Pediatric Dermatology

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In 1979 a registry of large (20 cm or more in diameter) congenital nevocytic nevi was established at the NYU Medical Center. To date, 56 patients have been entered. Seven were lost to follow-up. An additional two patients had melanoma on entry into the study and were therefore excluded from the results of prospective following such patients for the development of melanoma. Thus, this report concerns 47 individuals who were followed prospectively for a mean of 53 months, only 1 of whom developed melanoma. This was a 2-month-old girl at entry into the study who subsequently developed Touraine's syndrome. She eventually developed a primary melanoma in the central nervous system and died of metastatic disease at the age of 21 months.

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“…21 In a study that explored the risk of MM development and compared this to both the risks of anesthesia and psychosocial factors associated with living with a large nevus, the optimum time for surgical excision was between 6 and 9 months of age. 22 Treatment cannot eliminate the risk of developing MM because it may not be possible or unrealistic to remove every nevus cell. This was the case for a patient in Bett's article whose nevus was excised and repaired with a graft, and years later developed melanoma underneath the intact graft.…”

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confidence: 99%