Iatrogenic articular cartilage injury: the elephant in the operating theatre

Amin, Anish K.; Simpson, A. H. R. W.; Hall, Andrew C.

doi:10.1302/0301-620x.99b12.bjj-2017-1337

Cited by 13 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The general clinical symptoms of OA are joint pain, swelling, stiffness and crepitation, with loss of joint function subsequently affecting the quality of life in patients (Tawonsawatruk et al., 2018; Wysocka‐Skurska et al., 2016). OA might be the secondary complication to trauma and injury to the joint via cartilage injury, or disturbance to the stabilizing ligaments of the joints might be one of the causes of post‐traumatic secondary OA (Amin et al., 2017, Ross et al., 2017, Tawonsawatruk et al., 2018). Cartilage damage is commonly related to increased OA incidence.…”

Section: Introductionmentioning

confidence: 99%

Supercritical carbon dioxide decellularized porcine cartilage graft with PRP attenuated OA progression and regenerated articular cartilage in ACLT‐induced OA rats

Tarng

Hsu

et al. 2021

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Knee osteoarthritis (OA) is a common degenerative articular disorder and considered one of the primary causes of pain and functional disability. Knee OA is prevalent in 10% of men and 13% of women aged 60 years above. The study aims to use cartilage tissue engineering that combines the triads of decellularized porcine cartilage graft as “scaffold,” plasma rich platelet (PRP) as “signal” and chondrocytes from rat as “cell” to attenuate ACLT‐induced OA progression and regenerate the knee cartilage in rats. Decellularization of the porcine cartilage was characterized by hematoxylin and eosin, 4,6‐Diamidino‐2‐phenylindole staining, scanning electron microscopy and residual DNA quantification. The protective effect of decellularized porcine cartilage graft (dPCG) was evaluated by intra‐articular administration in surgically induced anterior cruciate ligament transection (ACLT) rat osteoarthritis (OA) model. Supercritical carbon dioxide technology completely decellularized the porcine cartilage. Intra‐articular administration of dPCG with or without PRP significantly reduced the ACLT‐induced OA symptoms and attenuated the OA progression. Pain‐relief by dPCG with or without PRP was assessed by capacitance meter and improved articular cartilage damage in the rat knee was characterized by X‐ray and micro‐CT. Besides, the histological analysis depicted cartilage protection by dPCG with or without PRP. The repairation and attenuation effect by dPCG with or without PRP in the articular knee cartilage damage were also explored by safranin‐O, type II collagen, aggrecan and SOX‐9 immuno‐staining. To conclude, intra‐articular administration of dPCG with or without PRP is efficient in repairing the damaged cartilage in the experimental OA model.

show abstract

Section: Introductionmentioning

confidence: 99%

Supercritical carbon dioxide decellularized porcine cartilage graft with PRP attenuated OA progression and regenerated articular cartilage in ACLT‐induced OA rats

Tarng

Hsu

et al. 2021

J Tissue Eng Regen Med

View full text Add to dashboard Cite

show abstract

“…Chondral lesions are a common additional finding occurring in up to 61% of all knee arthroscopies [1][2][3]. Cartilage lesions are graded according to the International Cartilage Repair Society 2 of 12 (ICRS) classification system [4,5].…”

Section: Introductionmentioning

confidence: 99%

Radiofrequency Chondroplasty May Not Have a Long-Lasting Effect in the Treatment of Concomitant Grade II Patellar Cartilage Defects in Humans

Koller

Springer

Rentenberger

et al. 2020

JCM

View full text Add to dashboard Cite

The effect of radiofrequency chondroplasty on cartilage tissue is not well studied. This prospective pilot study investigates the effect of radiofrequency chondroplasty on International Cartilage Repair Society (ICRS) grade II patellar cartilage defects using high-resolution magnetic resonance imaging (MRI) with T2 mapping. Six consecutive patients were treated for ICRS grade II patellar cartilage defects using radiofrequency chondroplasty. Before surgery and at defined follow-ups (2 weeks, 4 and 12 months) a high-resolution morphological 3 Tesla MRI with quantitative T2 mapping was performed. At baseline MRI, global T2 values of cartilage defects were increased (46.8 ms ± 9.7) compared to healthy cartilage (35.2 ms ± 4.5) in the same knee which served as reference. Two weeks after treatment, global T2 values (39.2 ms ± 7.7) of the defect areas decreased. However, global T2 values of the defect areas increased beyond the preoperative levels at 4 months (47.4 ms ± 3.1) and 12 months (51.5 ms ± 5.9), respectively. Zonal T2 mapping revealed that the predominant changes in T2 values occurred at the superficial cartilage layer. T2 mapping appears to be an ideal method to monitor cartilage degeneration after chondroplasty. Based on the small sample size of this pilot study, radiofrequency chondroplasty may cause cartilage damage and may not have a long-lasting effect in the treatment of grade II patellar cartilage defects. In five out of six patients, postoperative cartilage damage was observed on quantitative MRI. This study was therefore terminated before completion. We recommend only addressing the pathology which indicated arthroscopy and leaving concomitant cartilage lesions untreated.

show abstract

“…In addition, OA may be secondary to trauma, and injury to the joint is either by direct cartilage injury, or disruption to the ligamentous stabilizers of the joint, and may be one of the aetiologies of post-traumatic secondary OA. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Comparison of pain behaviour and osteoarthritis progression between anterior cruciate ligament transection and osteochondral injury in rat models

Tawonsawatruk

Sriwatananukulkit

Himakhun

et al. 2018

Bone & Joint Research

View full text Add to dashboard Cite

ObjectivesIn this study, we compared the pain behaviour and osteoarthritis (OA) progression between anterior cruciate ligament transection (ACLT) and osteochondral injury in surgically-induced OA rat models.MethodsOA was induced in the knee joints of male Wistar rats using transection of the ACL or induction of osteochondral injury. Changes in the percentage of high limb weight distribution (%HLWD) on the operated hind limb were used to determine the pain behaviour in these models. The development of OA was assessed and compared using a histological evaluation based on the Osteoarthritis Research Society International (OARSI) cartilage OA histopathology score.ResultsBoth models showed an increase in joint pain as indicated by a significant (p < 0.05) decrease in the values of %HLWD at one week post-surgery. In the osteochondral injury model, the %HLWD returned to normal within three weeks, while in the ACLT model, a significant decrease in the %HLWD was persistent over an eight-week period. In addition, OA progression was more advanced in the ACLT model than in the osteochondral injury model. Furthermore, the ACLT model exhibited a higher mean OA score than that of the osteochondral injury model at 12 weeks.ConclusionThe development of pain patterns in the ACLT and osteochondral injury models is different in that the OA progression was significant in the ACLT model. Although both can be used as models for a post-traumatic injury of the knee, the selection of appropriate models for OA in preclinical studies should be specified and relevant to the clinical scenario.Cite this article: T. Tawonsawatruk, O. Sriwatananukulkit, W. Himakhun, W. Hemstapat. Comparison of pain behaviour and osteoarthritis progression between anterior cruciate ligament transection and osteochondral injury in rat models. Bone Joint Res 2018;7:244–251. DOI: 10.1302/2046-3758.73.BJR-2017-0121.R2.

show abstract

Iatrogenic articular cartilage injury: the elephant in the operating theatre

Cited by 13 publications

References 23 publications

Supercritical carbon dioxide decellularized porcine cartilage graft with PRP attenuated OA progression and regenerated articular cartilage in ACLT‐induced OA rats

Supercritical carbon dioxide decellularized porcine cartilage graft with PRP attenuated OA progression and regenerated articular cartilage in ACLT‐induced OA rats

Radiofrequency Chondroplasty May Not Have a Long-Lasting Effect in the Treatment of Concomitant Grade II Patellar Cartilage Defects in Humans

Comparison of pain behaviour and osteoarthritis progression between anterior cruciate ligament transection and osteochondral injury in rat models

Contact Info

Product

Resources

About