IA-2A Positivity Rate at Manifestation of Type I Diabetes Mellitus in Slovak Children Culminates in September

Michalková, D; Mikulecký, M; Tomecková, E

doi:10.1515/jpem.2003.16.9.1263

Cited by 3 publications

(8 citation statements)

References 4 publications

(3 reference statements)

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“…In a small Slovakian study, IA-2A positivity at diagnosis showed seasonal cycling with a peak in fall. 29 Similar seasonality has not been observed in IAA 29 or Frequency (%)…”

Section: Discussionsupporting

confidence: 64%

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Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children

et al. 2022

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Aim We tested the hypothesis of a more aggressive disease process at diagnosis of type 1 diabetes during fall and winter, the colder seasons with consistently observed higher incidence of type 1 diabetes. Methods Seasonality in the manifestation of type 1 diabetes was examined in 4993 Finnish children and adolescents. Metabolic characteristics, beta‐cell autoantibodies and HLA class II genetics were analysed at clinical diagnosis. Results Significant seasonality was observed with higher number of new cases during fall and winter (n = 1353/27.1% and n = 1286/25.8%) compared with spring and summer (n = 1135/22.7% and n = 219/24.4%) (p < 0.001). The youngest children (aged 0.5–4 years) differed from the older ones (aged 5–14 years) as a minority of them were diagnosed in winter (p = 0.019) while the older children followed the same pattern as that seen in the total series. Poorer metabolic decompensation was observed during seasons with lower number of new diagnoses. Conclusion The heterogeneity in the seasonality of diabetes manifestation between younger and older children suggests that different environmental factors may trigger the disease at different ages. Poorer clinical condition associated with seasons with a lower number of new cases may be more likely to be due to a delay in seeking medical help than to a more aggressive autoimmunity.

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“…In a small Slovakian study, IA-2A positivity at diagnosis showed seasonal cycling with a peak in fall. 29 Similar seasonality has not been observed in IAA 29 or Frequency (%)…”

Section: Discussionsupporting

confidence: 64%

“…In a small Slovakian study, IA‐2A positivity at diagnosis showed seasonal cycling with a peak in fall 29 . Similar seasonality has not been observed in IAA 29 or GADA at diagnosis 29,30 . Thus, results concerning seasonality in the autoantibody profile at diagnosis are sparse and inconsistent.…”

Section: Discussionmentioning

confidence: 96%

Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children

et al. 2022

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“…For childhood DM1, seasonal cycling of some etiopathogenetic parameters has also been shown in relation to births, as in that of the HLA class II genes profile [16] and the insulin gene profile [17], or seasonal cycling of some autoantibodies [18] in relation to DM1 manifestations. Analogic investigations are not yet available for IBD.…”

Section: Discussionmentioning

confidence: 99%

Seasonality of births and childhood inflammatory bowel disease

Mikulecký

Čierna

2005

Wien Klin Wochenschr

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“…However, we failed to show seasonality in the number of positive autoantibodies at diagnosis and the only notable relationship between season of disease presentation and autoantibodies was higher ICA titers observed in autumn (Table S2). In a small Slovakian study, IA-2A positivity at diagnosis showed seasonal cycling with a peak in autumn [14]. Similar seasonality has not been observed in IAA [14] or GADA at diagnosis [14,15].…”

Section: Resultsmentioning

confidence: 60%

“…In a small Slovakian study, IA-2A positivity at diagnosis showed seasonal cycling with a peak in autumn [14]. Similar seasonality has not been observed in IAA [14] or GADA at diagnosis [14,15]. In a Belgian cohort, seasonality in the diagnosis of type 1 diabetes was restricted to HLA DR3/DR4-negative males [6].…”

Section: Resultsmentioning

confidence: 92%

Seasonal Variation in the Time of Disease Manifestation in Finnish Children with Type 1 Diabetes

Turtinen¹,

Härkönen²,

Ilonen³

et al. 2021

Preprint

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We tested the hypothesis of a more aggressive disease process at diagnosis of type 1 diabetes during autumn and winter, the colder seasons with consistently observed higher incidence of type 1 diabetes, compared to spring and summer. Seasonality in the manifestation of type 1 diabetes was examined in 4993 Finnish children and adolescents participated in the nationwide register. Clinical and metabolic characteristics, beta cell autoantibodies and HLA class II genetics were analysed at clinical diagnosis. Significant seasonality was observed with higher number of new cases during autumn and winter (n=1353/27.1% and n=1286/25.8%) compared to spring and summer (n=1135/22.7% and n=219/24.4%) (p<0.001). The youngest children (aged 0.5-4 years) differed from the older ones (aged 5-14 years) as their frequency of diagnoses was highest in autumn and the fewest cases were found in winter (p=0.019) while the older children followed the same pattern as that seen in the total series. Ketoacidosis was more frequent in children diagnosed during spring or summer compared to those diagnosed in autumn (18.8% and 19.9% vs. 15.8%, respectively; p=0.036) and weight loss was highest if diagnosed in summer (6% vs. 4.7˗5.4%; p<0.001). No relationship was observed between the season of disease presentation and diabetes-associated autoantibodies or HLA genotypes.Conclusions: Contrary to our working hypothesis, more severe metabolic decompensation was seen during seasons with lower number of new cases. The heterogeneity in the seasonality of diabetes manifestation between younger and older children suggests that there could be different environmental factors triggering the disease at different ages.Trial registration number: 454/E//2001Date of registration: 19.9.2001

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IA-2A Positivity Rate at Manifestation of Type I Diabetes Mellitus in Slovak Children Culminates in September

Abstract: The maximum autoantibody levels were found for those manifesting the disease in late summer and early autumn--the only time of year in Slovakia when both the numbers of births of future diabetic children as well as those of manifestation of new cases are significantly above average.

Cited by 3 publications

References 4 publications

Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children

Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children

Seasonality of births and childhood inflammatory bowel disease

Seasonal Variation in the Time of Disease Manifestation in Finnish Children with Type 1 Diabetes

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