Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children

Turtinen, Maaret; Härkönen, Taina; Ilonen, Jorma; Parkkola, Anna; Knip, Mikael

doi:10.1111/apa.16282

Cited by 8 publications

(2 citation statements)

References 43 publications

(71 reference statements)

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“…Higher incidence during the winter and fall periods was probably the result of a higher infection rate during cold weather. Our study confirms previous study findings [42,43] that children were diagnosed with T1D more often in the cold seasons, with 53% of cases diagnosed in fall or winter (p = 0.0001). Studies during the COVID-19 pandemic [44] revealed that cold and winter conditions were associated with greater SARS-CoV-2 transmission in Western countries.…”

Section: Discussionsupporting

confidence: 92%

The COVID-19 Pandemic Increased the Incidence of New-Onset Type One Diabetes in Children

Blumenfeld,

Rozenshmidt,

Eini

et al. 2024

Children

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Background: The impact of the COVID-19 pandemic on the incidence rate of childhood type 1 diabetes (T1D) is controversial. Our aim was to analyze the incidence of new-onset T1D among children aged 0–17 before and during the COVID-19 pandemic in Israel. Methods: Data obtained from the national T1D registry for children aged 0–17 were analyzed for the pre-pandemic (1997–2019) and pandemic (2020–2022) periods. In the pre-pandemic period, 7246 children with newly diagnosed T1D were compared with 1490 children diagnosed during the pandemic period. Results: T1D incidence significantly increased in the 0–17 age group from a mean of 12.9/105 (pre-pandemic) to 17.7/105 and 16.7/105 during the first two years of the pandemic (2020 and 2021, respectively) (p = 0.0001). Stratifying by age group (0–4, 5–9, 10–14, and 15–17) revealed a significant increase in the 5–9, 10–14, and 15–17 groups, both in 2020 (p = 0.0001) and in 2021 (p = 0.0001). The incidence rate in the 0–4 age group showed no change in the first year of the pandemic (2020) (p = 0.4). However, in the second year of the pandemic (2021), there was a significant increase from 6.3/105 in the pre-pandemic period to 9.1/105 (p = 0.001). Anti-COVID-19 vaccination in 2022 led to a significant decrease in the incidence rates in the 10–14 and 15–17 age groups (p = 0.03 and p = 0.02, respectively). Conclusion: The COVID-19 pandemic was associated with a significant increase in the incidence of new-onset T1D in prepubertal and pubertal children. Anti-COVID-19 vaccination decreased the incidence rate significantly only in pubertal children.

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Section: Discussionsupporting

confidence: 92%

The COVID-19 Pandemic Increased the Incidence of New-Onset Type One Diabetes in Children

Blumenfeld,

Rozenshmidt,

Eini

et al. 2024

Children

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“…Previously there had been a consistent pattern of new diagnoses of Type 1 amongst CYP with a spike in new diagnoses during winter months and fall in the summer. This is a well-known phenomenon in other countries with high incidence of diabetes[ 8 ]. The reason for this is unclear but it has been suggested that this could be due to increase in viral illnesses during winter months[ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Ten-year review of trends in children with type 1 diabetes in England and Wales

Ng¹,

Soni²

2023

World J Diabetes

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The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health concerns. Cardiovascular complications associated with diabetes are the leading cause of morbidity and mortality. The cardiovascular diseases that accompany diabetes include angina, myocardial infarction, stroke, peripheral artery disease, and congestive heart failure. Among the various risk factors generated secondary to hyperglycemic situations, advanced glycation end products (AGEs) are one of the important targets for future diagnosis and prevention of diabetes. In the last decade, AGEs have drawn a lot of attention due to their involvement in diabetic patho-physiology. AGEs can be derived exogenously and endogenously through various pathways. These are a nonhomogeneous, chemically diverse group of compounds formed nonenzymatically by condensation between carbonyl groups of reducing sugars and free amino groups of protein, lipids, and nucleic acid. AGEs mediate their pathological effects at the cellular and extracellular levels by multiple pathways. At the cellular level, they activate signaling cascades via the receptor for AGEs and initiate a complex series of intracellular signaling resulting in reactive oxygen species generation, inflammation, cellular proliferation, and fibrosis that may possibly exacerbate the damaging effects on cardiac functions in diabetics. AGEs also cause covalent modifications and cross-linking of serum and extracellular matrix proteins; altering their structure, stability, and functions. Early diagnosis of diabetes may prevent its progression to complications and decrease its associated comorbidities. In the present review, we recapitulate the role of AGEs as a crucial mediator of hyperglycemia-mediated detrimental effects in diabetes-associated complications. Furthermore, this review presents an overview of future perspectives for new therapeutic interventions to ameliorate cardiovascular complications in diabetes.

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Climate change

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2024

Environmental Pollution and Type 2 Diabetes Mellitus

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Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children

Cited by 8 publications

References 43 publications

The COVID-19 Pandemic Increased the Incidence of New-Onset Type One Diabetes in Children

The COVID-19 Pandemic Increased the Incidence of New-Onset Type One Diabetes in Children

Ten-year review of trends in children with type 1 diabetes in England and Wales

Climate change

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