The internet and digital transformation have changed our relations with the market. These technologies have been developing continuously, creating opportunities for new business models, and e-commerce has grown overwhelmingly worldwide, changing the consumption process of a large part of the world's population. Companies are increasingly using blockchain technology to improve and create new global trading business models. Blockchain had its first application in cryptocurrencies, but it has quickly become a major solution in all sorts of activity sectors, providing increased security in commercial transactions. An important question is how the blockchain can leverage e-commerce in solving problems and improving business results. It was concluded that blockchain could leverage e-commerce in the four fundamental areas of (1) e-commerce financial transactions, (2) e-commerce supply chain management, (3) e-commerce forecasting and contractual relations, and (4) e-commerce transactions systems' trust and credibility.