<i>ZNNT1</i> long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression

Li, Peng; He, Jie; Yang, Zhi; Ge, Shengfang; Zhang, He; Zhong, Qing; Fan, Xianqun

doi:10.1080/15548627.2019.1659614

Cited by 85 publications

(60 citation statements)

References 39 publications

(47 reference statements)

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“…Notably, also patient-derived serum samples from melanoma patients with high level of autophagy flux have shown high levels of these proteins [81], suggesting that they can serve as surrogates for intra-tumoral autophagy dynamics. Elevated autophagy accompanying melanoma progression has been associated with loss of galectin-3 [82], increased levels of sirtuin 1 (SIRT1) [83], SIRT6 [84,85], BNIP3 [86], and long non-coding RNA ZNNT1 [87], and enhanced activity of signaling pathways such as AKT, independent of the mutational status of BRAF [88]. A heterozygous loss of ATG5 enhanced melanoma metastasis and predicted poor overall patient survival [89].…”

Section: Autophagy In Melanomamentioning

confidence: 99%

Non-Apoptotic Cell Death Signaling Pathways in Melanoma

Hartman

2020

IJMS

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Resisting cell death is a hallmark of cancer. Disturbances in the execution of cell death programs promote carcinogenesis and survival of cancer cells under unfavorable conditions, including exposition to anti-cancer therapies. Specific modalities of regulated cell death (RCD) have been classified based on different criteria, including morphological features, biochemical alterations and immunological consequences. Although melanoma cells are broadly equipped with the anti-apoptotic machinery and recurrent genetic alterations in the components of the RAS/RAF/MEK/ERK signaling markedly contribute to the pro-survival phenotype of melanoma, the roles of autophagy-dependent cell death, necroptosis, ferroptosis, pyroptosis, and parthanatos have recently gained great interest. These signaling cascades are involved in melanoma cell response and resistance to the therapeutics used in the clinic, including inhibitors of BRAF mut and MEK1/2, and immunotherapy. In addition, the relationships between sensitivity to non-apoptotic cell death routes and specific cell phenotypes have been demonstrated, suggesting that plasticity of melanoma cells can be exploited to modulate response of these cells to different cell death stimuli. In this review, the current knowledge on the non-apoptotic cell death signaling pathways in melanoma cell biology and response to anti-cancer drugs has been discussed.

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Section: Autophagy In Melanomamentioning

confidence: 99%

Non-Apoptotic Cell Death Signaling Pathways in Melanoma

Hartman

2020

IJMS

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“…Of targets, It is postulated that lncRNA PVT1 acts by repressing mi-RNA 17-3, which interacts with MDM2 and p53 proteins [71]. By promoting autophagy, lncRNA ZNNT1 has also been associated with in vitro UM cell death [73]. Other lncRNAs such as lncRNA FTH1P3 [74], lncRNA MALAT1 [75], or HOXA11-AS [76] have also been incriminated in UM tumorigenesis.…”

Section: Main Clinical Findingsmentioning

confidence: 99%

Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives

Martel

Baillif²,

Nahon-Estève³

et al. 2020

Cancers

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Tissue biopsy is considered the gold standard when establishing a diagnosis of cancer. However, tissue biopsies of intraocular ophthalmic malignancies are hard to collect and are thought to be associated with a non-negligible risk of extraocular dissemination. Recently, the liquid biopsy (LB) has emerged as a viable, non-invasive, repeatable, and promising way of obtaining a diagnosis, prognosis, and theragnosis of patients with solid tumors. LB refers to blood, as well as any human liquid. The natural history of uveal melanoma (UM) and retinoblastoma (RB) are radically opposed. On the one hand, UM is known to disseminate through the bloodstream, and is, therefore, more accessible to systemic venous liquid biopsy. On the other hand, RB rarely disseminates hematogenous, and is, therefore, more accessible to local liquid biopsy by performing an anterior chamber puncture. In this review, we summarize the current knowledge concerning LB in UM, RB, conjunctival tumors, and choroidal metastases. We also develop the current limitations encountered, as well as the perspectives.

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“…The role of autophagy in cancer varies from person to person. On the one hand, autophagy contributes to maintaining cellular homeostasis and can suppress tumor growth; on the other hand, autophagy may also facilitate proliferation and survival of tumor cells thus promoting tumor growth, invasion, and metastasis [ 85 , 86 ]. In recent years, more and more studies have shown that autophagy played a key role in the development of tumors, including cell proliferation, metastasis, and chemotherapy resistance [ 87 ].…”

Section: Lncrna As Regulators Of Autophagy In Neurological Diseasementioning

confidence: 99%

Autophagy-Associated lncRNAs: Promising Targets for Neurological Disease Diagnosis and Therapy

Cui

Zhong

et al. 2020

Neural Plasticity

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Neurological diseases are a major threat to global public health and prosperity. The number of patients with neurological diseases is increasing due to the population aging and increasing life expectancy. Autophagy is one of the crucial mechanisms to maintain nerve cellular homeostasis. Numerous studies have demonstrated that autophagy plays a dual role in neurological diseases. Long noncoding RNAs (lncRNAs) are a vital class of noncoding RNAs with a length of more than 200 nucleotides and cannot encode proteins themselves but are expressed in most neurological diseases. An early phase, emerging knowledge has revealed that long noncoding RNAs (lncRNAs) are crucial in autophagy regulation. Furthermore, autophagy-associated lncRNAs can promote the development of neurological diseases or slow their progression. In this review, we introduce a general overview of lncRNA functional mechanisms and summarizes the recent progress of lncRNAs on autophagy regulation in neurological diseases to reveal possible novel therapeutic targets or useful biomarkers.

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ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression

Cited by 85 publications

References 39 publications

Non-Apoptotic Cell Death Signaling Pathways in Melanoma

Non-Apoptotic Cell Death Signaling Pathways in Melanoma

Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives

Autophagy-Associated lncRNAs: Promising Targets for Neurological Disease Diagnosis and Therapy

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