Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non‐Small Cell Lung Cancer Patients: Confirmation of a TCM Concept

Abstract

Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM Yin-cold (YC) or Yang-heat (YH) syndrome types and the EGFR gene status, we prospectively studied 310 NSCLC patients. TCM YH or YC was diagnosed by three TCM experts. TCM symptoms and signs were entered into a binary cluster analysis. The relationships between the EGFR gene status, YH or YC syndrome types, and classification by cluster analysis were analyzed using the chi-square test and multivariate logistic regression. In the 299 patients who had their EGFR gene tested, 45.24% YC (76/168) and 25.95% YH (34/131) patients had EGFR mutations (p = 0.001). Among the 292 patients entered into the cluster analysis, 132 were classified into group A, with signs and symptoms similar to YC, whereas 160 group B patients were similar to YH. In the 281 patients with EGFR tested, 45.67% group A (58/127) and 28.57% group B patients (44/154) had EGFR mutations (p = 0.003). The EGFR status was independently correlated with TCM syndrome type and classification by cluster analysis on multivariate logistic regression. NSCLC patients with YC were more likely to have EGFR gene mutations.

Altered Resting-State Brain Activities in Drug-Naïve Major Depressive Disorder Assessed by fMRI: Associations With Somatic Symptoms Defined by Yin-Yang Theory of the Traditional Chinese Medicine

“…The Yang group feels hot or has hot flashes, sweats during daily activities, and prefers cool environments and cold beverages and food. The Yin group feels cold or has cold flashes, does not sweat even during strenuous exercise, and prefers warm environments and hot beverages and food ( 18 ). We also confirmed that matched healthy control subjects had no somatic symptoms.…”

Combination with cooling-heat Chinese medicine Qing-kai-ling, not warming-yang Shen-fu, enhances the antitumor effect of gefitinib in resistant non-small cell lung cancer models in vitro and in vivo

“…Therefore, the warming-yang or cooling-heat should be the guide of treatment principle outline 5 . We have demonstrated that EGFR gene mutated NSCLC patients are more likely with YC syndrome type 6 . Besides, the most common side effect of EGFR-TKIs was red acneiform rashes [7][8][9][10][11] , with thirsty, red and dry tongue and yellow tongue coating, which are typical symptoms and signs for YH syndrome type.…”

Network Pharmacology‐Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer

“…Evidence-Based Complementary and Alternative Medicine in mice [40]. Zhu et al indicate that the EGFR status is independently correlated with TCM treatment in non-smallcell lung cancer patients [41]. Although previous study has confirmed the relation between EGFR expression and TCM active compounds using cell membrane chromatography [42], the effect of Xihuang pill on EGFR expression in liver cancer is still unclear.…”