<i>Wolbachia</i>
-carrying <i>Aedes</i>
 mosquitoes for preventing dengue infection

Fox, Tilly; Sguassero, Yanina; Richardson, Marty; Rose, Winsley; Doum, Dyna; Arévalo-Rodríguez, Ingrid; Villanueva, Gemma

doi:10.1002/14651858.cd015636

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…We observed different directionalities of interactions in the screen (mAdV2 + Shigella vs + Yersinia), indicating that the molecular interactions vary from one pathogen to another. Besides, there are published studies describing how invasion of one pathogen excludes infection with another, such as in the case of Norovirus and Salmonella 70 , Wolbachia and Dengue Virus 71 , while others indicate a synergistic effect on invasion 72 .…”

Section: Discussionmentioning

confidence: 99%

Dissecting the impact of enteric viral-bacterial co-infection on the host innate immune response and its implications for pathogenicity

Broz,

Walch

2024

Preprint

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Understanding how pathogens cause and maintain infection is essential to develop novel therapeutics and prevent outbreaks of emerging diseases. While the broadening of accessible methodologies has enabled mechanistic insights into single pathogen infections, the molecular mechanisms underlying co-infections remain elusive, despite their clinical frequency and relevance, generally exacerbating symptom severity and fatality. Here, we describe a first-of-its-kind, parallelized, unbiased screening of pairwise co-infections, ensuring reliability through robust quality control and validation. We subsequently decipher two distinct molecular interaction points: Firstly, mAdV3 modifies ASC-dependent inflammasome responses, altering host cell death and cytokine production, thereby impacting secondary Salmonella infection. Secondly, mAdV2 infection triggers upregulation of Mprip, a crucial mediator of phagocytosis, which in turn causes increased Yersinia uptake, specifically in virus pre-infected cells. This work encompasses both a valuable resource, which will spark further hypothesis-driven research, and molecular characterization of novel interaction points during co-infection, presenting putative targets for new therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Dissecting the impact of enteric viral-bacterial co-infection on the host innate immune response and its implications for pathogenicity

Broz,

Walch

2024

Preprint

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“…aegypti when some of them have antecedently incorporated the opposite view, clearly requisites an exceptional step, starting with (1) community awareness-arousing [70] and (2) intense bidirection communication to turn initially opposite community members into participants and even partners [71]. The information and awareness campaign should explain the features of the innovations [72], including strengths [73] and its weaknesses [74,75], the release procedures (areas, dates, etc.) which intended to suppress or to replace initial mosquito population [76], the potential risks [16] and, especially, the activities in which the community should intervene or participate [66,71].…”

Section: Effective Communication [57] Transparency [58]mentioning

confidence: 99%

Safety and Proven Risk Assessment on the Release of Wolbachia-Inserted Aedes Aegypti: Lesson Learned from the Partial Resistance of the Community

Siagian

2023

AJRID

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Aims: to describe the basis of partial rejection from the community regarding the government's plan to expand the range of releases of Aedes aegypti mosquitoes which have been inserted with the endosymbiont bacteria Wolbachia spp. to reduce the incidence of dengue hemorrhagic fever and offers a more rational approach based on community based medicine to educate massively first before expecting community participation. Discussion: Aedes aegypti which laboratorily inserted with Wolbachia, an endosymbiont bacterium, naturally occurring in insects is actually a great success story in several countries, e.g., Brazil. In Jogjakarta, Indonesia this success story also repeated even though unfortunately when the government tries to expand the programme, some part of the community reject it. Lack of sufficient community education perhaps become the main reason of rejection from those who do not understand yet regarding the benefit. Conclusion: Tackling social determinants of Health is necessary in order to make a national programme can be implemented and receive support from the community.

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“…Its application is enormous and promising for agricultural pests such as fruit flies; flea beetle, Aphthona spp., to control leafy spurge 1 ; house fly, Musca domestica , and stable fly, Stomoxys calcitran s 2 . In addition, this approach has been practiced for medically important vector control programs including Aedes vectors 3 – 5 ; and paratransgenesis of Wolbachia is being considered for use in mosquitoes to reduce the spread of malaria 6 and in tsetse fly to reduce the spread of sleeping sickness 7 . Moreover, other mosquito species, such as Aedes polynesiensis (South Pacific) 8 , Aedes albopictus (Italy) 9 , and Culex quinquefasciatus (southwestern Indian ocean) 10 , have also been field tested to determine the feasibility of using Wolbachia -based population suppression technology in the near future.…”

Section: Introductionmentioning

confidence: 99%

Diversity of Wolbachia infections in Sri Lankan mosquitoes with a new record of Wolbachia Supergroup B infecting Aedes aegypti vector populations

Wijegunawardana,

Gunawardene,

Abeyewickreme

et al. 2024

Sci Rep

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Wolbachia bacteria are common endosymbionts of insects and have recently been applied for controlling arboviral vectors, especially Aedes aegypti mosquito populations. However, several medically important mosquito species in Sri Lanka were present with limited information for the Wolbachia infection status. Therefore, the screening of Wolbachia in indigenous mosquitoes is required prior to a successful application of Wolbachia-based vector control strategy. In this study, screening of 78 mosquito species collected from various parts of the country revealed that 13 species were positive for Wolbachia infection, giving ~ 17% infection frequency of Wolbachia among the Sri Lankan mosquitoes. Twelve Wolbachia-positive mosquito species were selected for downstream Wolbachia strain genotyping using Multi Locus Sequencing Type (MLST), wsp gene, and 16S rRNA gene-based approaches. Results showed that these Wolbachia strains clustered together with the present Wolbachia phylogeny of world mosquito populations with some variations. Almost 90% of the mosquito populations were infected with supergroup B while the remaining were infected with supergroup A. A new record of Wolbachia supergroup B infection in Ae. aegypti, the main vectors of dengue, was highlighted. This finding was further confirmed by real-time qPCR, revealing Wolbachia density variations between Ae. aegypti and Ae. albopictus (p = 0.001), and between males and females (p < 0.05). The evidence of natural Wolbachia infections in Ae. aegypti populations in Sri Lanka is an extremely rare incident that has the potential to be used for arboviral vector control.

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Wolbachia -carrying Aedes mosquitoes for preventing dengue infection

Cited by 5 publications

References 27 publications

Dissecting the impact of enteric viral-bacterial co-infection on the host innate immune response and its implications for pathogenicity

Dissecting the impact of enteric viral-bacterial co-infection on the host innate immune response and its implications for pathogenicity

Safety and Proven Risk Assessment on the Release of Wolbachia-Inserted Aedes Aegypti: Lesson Learned from the Partial Resistance of the Community

Diversity of Wolbachia infections in Sri Lankan mosquitoes with a new record of Wolbachia Supergroup B infecting Aedes aegypti vector populations

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