Dissecting the impact of enteric viral-bacterial co-infection on the host innate immune response and its implications for pathogenicity
Petr Broz,
Philipp Walch
Abstract:Understanding how pathogens cause and maintain infection is essential to develop novel therapeutics and prevent outbreaks of emerging diseases. While the broadening of accessible methodologies has enabled mechanistic insights into single pathogen infections, the molecular mechanisms underlying co-infections remain elusive, despite their clinical frequency and relevance, generally exacerbating symptom severity and fatality. Here, we describe a first-of-its-kind, parallelized, unbiased screening of pairwise co-i… Show more
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