<i>Withania somnifera</i>Improves Semen Quality in Stress-Related Male Fertility

Mahdi, Abbas Ali; Shukla, Kamla Kant; Ahmad, Mohammad Kaleem; Rajender, Singh; Shankhwar, Satya Narain; Singh, Vishwajeet; Dalela, Deepansh

doi:10.1093/ecam/nep138

Cited by 84 publications

(68 citation statements)

References 30 publications

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“…Believed to have relatively lower negative side effects, herbal is more preferable than synthetic medicine [16][17][18]. L-Dopa is an important component of velvet beans [22].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Indonesian Velvet Bean Extract on the Fertility of Albino Male Mice

Sardjono

Pradipta

Musthapa

2016

Int J Pharm Pharm Sci

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Objective: This research aims to determine the dose of Indonesian velvet bean (Mucuna pruriens) extract which has significant effect on the ferlitity mice (concentration, motility and morphology of mice sperm). The extract is expected to become an alternative infertility herbal medicine relatively more secure and affordable replacing synthetic hormonal drugs which tend to have negative effects. Methods:The seed was taken from Yogyakarta Indonesia. Fertility test was done to fertile adult male albino mice 12 w old, weighing 25-35 grams. Fertility tests performed on seven groups of mice; i.e. negative control, positive control and treatment groups (five dose levels at 50, 100, 150, 200 and 250 mg/kg body weight). Subsequent fertility test results were statistically tested, including tests of normality (Kolmogorov-Sminov) followed by T test (Independent-Samples T Test). Results:The sperm concentration and motility increased as an increased dose of seed extract was applied, as well as decreased abnormal morphology. The highest change in the quality and quantity of sperm occurred at the dose of 250 mg/kg body weight with increased sperm concentration of about 22 million, sperm motility increased by 18% and decreased abnormal sperm morphology by 12%. Statistical analysis showed a significant increase in sperm concentration and motility at doses of 100, 150, 200 and 250 mg/kg body weight, whereas a significant decrease of abnormal sperm morphology was found at doses of 150, 200 and 250 mg/kg body weight. Conclusion: Based on this study it is concluded that IKeywords: Mucuna pruriens, L-dopa, Sperm Concentration, Sperm Motility, Sperm Morphology ndonesian velvet beans seed extract can increased the fertility of albino male mice significantly at dose level 250 mg/kg body weight.

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“…Believed to have relatively lower negative side effects, herbal is more preferable than synthetic medicine [16][17][18]. L-Dopa is an important component of velvet beans [22].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Indonesian Velvet Bean Extract on the Fertility of Albino Male Mice

Sardjono

Pradipta

Musthapa

2016

Int J Pharm Pharm Sci

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“…The powdered Ayurvedic herbal drug mixture used in this patient primarily targets adaptogenic, rejuvenative, aphrodisiac, and general strengthening as well as strengthening of the reproductive tissues; it helps enhancing digestion and cognition and has mild anxiolytic and antidepressant properties ( W. somnifera [50,51,52,53,54,55], A. racemosus [56,57,58,59,60,61], T. cordifolia [62,63,64,65,] B. monnieri [66,67,68,69,70])[. ]…”

Section: Conclusion and Discussionmentioning

confidence: 99%

The Effect of a Complex Multi-modality Ayurvedic Treatment in a Case of Unknown Female Infertility

Kessler

Stapelfeldt²,

Michalsen

et al. 2015

Complement Med Res

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Background: Treatment of female infertility has been growing globally in recent years. In spite of improvements in medical strategies and the improved outcomes for infertile couples, treatment attempts remain largely unsuccessful. A growing number of patients pursue complementary and alternative medicine treatment options like Ayurveda that offers a variety of inpatient and outpatient treatments for infertility. Case Report: A case of a 38 year-old woman with infertility of unknown origin is presented. She received 18 conventional fertility treatments in 5 different fertility centers and 3 different countries. After several complications, the patient quitted conventional treatment and admitted to an Ayurvedic outpatient clinic where she received a complex Ayurvedic treatment, which included botanicals, dietary and lifestyle advice, manual therapy, yoga, and spiritual elements. The patient then became pregnant and gave birth to a healthy boy in 2012. Conclusions: Ayurveda may be a useful complementary option in the case of futile conventional treatment attempts in female infertility. Nevertheless, the evidence base for Ayurvedic interventions remains weak and requires well-designed clinical trials. This case raises some questions, such as whether the exposure to a large number of assisted reproduction procedures can lead to more health problems than health benefits. The Ayurvedic approach to fertility strives first to improve the health of the patient leading to a higher likelihood of pregnancy. As this is a case report, we are not able to exclude temporal factors stimulating the pregnancy. However, the chronology suggests that this approach might have been an important factor in the eventual pregnancy.

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“…Withania somnifera root powder when administered to normozoospermic infertile man in a dosage of 5 g/ day for 3 months showed a significant reduction in stress, improved antioxidants, and enhanced semen volume and levels of vitamins A, C, and E and also corrected fructose. This herb's action at the HPG axis level is also evident through various studies, one such showed significant increased serum testosterone and LH levels and decreased levels of FSH and prolactin (PRL) in infertile men [24][25][26].…”

Section: Some Common Ayurvedic Herbs To Improve Male Fertility Ashwagmentioning

confidence: 91%

Medicinal herbs in the management of male infertility

Dutta¹,

Sengupta²

2018

J Pregnancy Reprod

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Male infertility can range from neurohormonal imbalances, reproductive tissue disruptions, qualitative and quantitative deterioration of semen to sexual behavioral problems. The global deterioration of male reproductive health is a major concern and the modern therapeutic approaches to combat male infertility are expensive, less accessible, have long term treatment tenure and possess various side effects. Whereas, the herbal therapies, are better positioned to offer more holistic approaches to improve male reproductive health. In Ayurvedic pharmacology, there exists a special group of herbs, classified as vajikarana or aphrodisiacs, which nourishes and stimulates the sexual tissues. This review concentrates on the Ayurvedic approach to ameliorate male reproductive health referring to some of the most important scientifically tested herbs which have been reported to accentuate male fertility by imposing either stimulating or nourishing effects on the male reproductive organs.

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Withania somniferaImproves Semen Quality in Stress-Related Male Fertility

Cited by 84 publications

References 30 publications

The Effect of Indonesian Velvet Bean Extract on the Fertility of Albino Male Mice

The Effect of Indonesian Velvet Bean Extract on the Fertility of Albino Male Mice

The Effect of a Complex Multi-modality Ayurvedic Treatment in a Case of Unknown Female Infertility

Medicinal herbs in the management of male infertility

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