<i>Umbilicaria subpolyphylla</i>Oxner: the correct name for<i>U. iberica</i>Sancho &amp; Krzewicka and its bipolar distribution pattern

Davydov, Evgeny A.; Blum, Oleg; Kashevarov, G.P.; Grakhov, Vladimir P.

doi:10.1017/s002428291900015x

Cited by 7 publications

(6 citation statements)

References 30 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, although umbilicaric acid is reported from some Umbilicaria species ( U. grisea, U. freyi, U. mühlenbergii and U. subpolyphylla (31, 61)), O-methyltransferase (OMT) was not identified in the depside-related BGC of any Umbilicaria species (Fig. 3).…”

Section: Discussionmentioning

confidence: 99%

A candidate gene cluster for the bioactive natural product gyrophoric acid in lichen-forming fungi

Singh

Calchera

Merges

et al. 2022

Preprint

View full text Add to dashboard Cite

Natural products of lichen-forming fungi are structurally diverse and have a variety of medicinal properties. Yet they a have limited implementation in industry as for most of the natural products, the corresponding genes remain unknown. Here we implement a long-read sequencing and bioinformatic approach to identify the biosynthetic gene cluster of the bioactive natural product gyrophoric acid (GA). Using 15 high-quality genomes representing nine GA-producing species of the lichen-forming fungal genus Umbilicaria, we identify the most likely GA cluster and investigate cluster gene organization and composition across the nine species. Our results show that GA clusters are promiscuous within Umbilicaria with only three genes that are conserved across species, including the PKS gene. In addition, our results suggest that the same cluster codes for different but structurally similar NPs, i.e., GA, umbilicaric acid and hiascic acid, bringing new evidence that lichen metabolite diversity is also generated through regulatory mechanisms at the molecular level. Ours is the first study to identify the most likely GA cluster. This information is essential for opening up avenues for biotechnological approaches to producing and modifying GA, and possibly other lichen compounds. We show that bioinformatics approaches are useful in linking genes and potentially associated natural products. Genome analyses help unlocking the pharmaceutical potential of organisms such as lichens, which are biosynthetically diverse, but slow growing, and usually uncultivable due to their symbiotic nature.

show abstract

Section: Discussionmentioning

confidence: 99%

A candidate gene cluster for the bioactive natural product gyrophoric acid in lichen-forming fungi

Singh

Calchera

Merges

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Interestingly, although umbilicaric acid is reported from some Umbilicaria species ( U. grisea , U. freyi , U. muhlenbergii , and U. subpolyphylla [ 31 , 40 ]), O -methyltransferase (OMT) was not identified in the depside-related BGC of any Umbilicaria species ( Fig. 3A and B ).…”

Section: Discussionmentioning

confidence: 99%

A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Secondary products were analyzed by applying standard thin-layer chromatography techniques (Culberson & Kristinsson 1970) using solvents A, B and C (Culberson & Johnson 1982). The high-performance liquid chromatography (HPLC) analysis was performed as described in Davydov et al (2019 a ).…”

Section: Methodsmentioning

confidence: 99%

Umbilicaria orientalis– a new species ofUmbilicariasubg.Papillophorawith an East Asian distribution: morphological delimitation and molecular evidence

et al. 2020

Self Cite

View full text Add to dashboard Cite

Umbilicaria orientalis Davydov sp. nov. is described and phylogenetic analysis (ITS, mtLSU and RPB2) confirmed its distinctness and indicated a sister relationship with U. trabeculata within the U. vellea group. The species is morphologically similar to U. vellea but differs by simple, cylindrical or strap-like rhizinomorphs and by thalloconidia, developing both on the lower surface and on rhizinomorphs, that are 1–2 (rarely 4)–celled or in aggregates of up to 5–6 cells. Umbilicaria orientalis is described from the Russian Far East and is currently known from a wide range of localities in East Asia, from the Far East to South Siberia and Mongolia in the north, to Hebei and Tibet in the south. New sequences of U. americana were obtained; the species represents an independent phylogenetic lineage within Umbilicaria subg. Papillophora. Diagnostic traits and variability of different developmental stages of U. orientalis, as well as its East Asian distribution pattern, are discussed.

show abstract

Umbilicaria subpolyphyllaOxner: the correct name forU. ibericaSancho & Krzewicka and its bipolar distribution pattern

Cited by 7 publications

References 30 publications

A candidate gene cluster for the bioactive natural product gyrophoric acid in lichen-forming fungi

A candidate gene cluster for the bioactive natural product gyrophoric acid in lichen-forming fungi

A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi

Umbilicaria orientalis– a new species ofUmbilicariasubg.Papillophorawith an East Asian distribution: morphological delimitation and molecular evidence

Contact Info

Product

Resources

About