Tremellafuciformis polysaccharides inhibit UVA‐induced photodamage of human dermal fibroblast cells by activating up‐regulating Nrf2/Keap1 pathways

Abstract

It is well known that exposure to sunlight is the main cause of oxidative stress in human dermal fibroblasts cells. UVA radiation (320-400 nm) can increase the production of reactive oxygen species (ROS) in cells. By reducing the content of ROS, some active enzyme substances with various antioxidant effects can affect oxidative stress. 1 The enzyme antioxidant system mainly includes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

“…Cell experiments have showed that NPs from fungi could regulate Nrf2 antioxidant pathway for liver protection ( 192 ), lung protection ( 33 , 105 ), cardioprotection ( 193 ), gastrointestinal protection ( 113 ), anti-oxidation ( 194 , 195 ), anti-aging ( 108 , 196 , 197 ), anti-diabetic ( 102 , 198 ), anti-cancer ( 199 ), and anti-atherosclerosis ( 29 ). Antrodia camphorate polysaccharide exhibited liver protection on LPS-induced Kupffer cells by increasing protein expressions of Keap1, Nrf2, and γ-GCS ( 192 ).…”

“…NPs from fungi had anti-oxidation activity on H 2 O 2 -induced HSFs ( 194 ) and LPS-induced RAW264.7 cells ( 195 ) through augmenting protein and/or mRNA expressions of Nrf2, Gstm1, Gstt1, GCLC, GCLM, HO-1, and NQO1, and reducing Keap1 mRNA expression. Those from fungi displayed anti-aging effect against L-Glu-induced HT22 cells ( 108 , 196 ) and UVA-induced HDF cells ( 197 ) via aggrandizing protein and/or mRNA expressions of nuclear Nrf2, Nrf2, SOD1, HO-1, NQO1, and GCLC, and lowering protein and/or mRNA expressions of Keap1 and cytosol Nrf2. Lentinus edodes mycelium polysaccharide had anti-diabetic action against high glucose-induced MIN6 or INS-1 cells, which was related to increment of nuclear Nrf2 protein expression ( 102 , 198 ).…”

Extraction, isolation, purification, derivatization, bioactivity, structure–activity relationship, and application of polysaccharides from White jellyfungus

“…Talking about diabetes, people are no strangers to it. In the last century, it was relatively rare for people to get diabetes around the age of 40, however, nowadays, diabetes is getting younger and younger in China; the prevalence of type II diabetes has reached 2% among people aged 8-29 and 6.3% among people aged 30-39, and according to research surveys, the number of people with diabetes in China has exceeded 100 million, ranking first in the world (Fu et al, 2021;Y. Zheng et al, 2019).…”

“…Of course, not away from electronic products can avoid being radiation, in nature, ultraviolet radiation will also affect humans, in some tropical and subtropical areas, due to the strong sunlight, people are subject to strong ultraviolet radiation, which will also be easy to cause skin damage, so in the strong ultraviolet environment should also be done to protect the skin. Fu et al (2021) found that pretreatment with White jellyfungus polysaccharide reduced oxidative stress in UVA‐irradiated human dermal fibroblasts after the pretreatment resulted in a significant reduction in intracellular ROS content, as well as a significant increase in the content of type I collagen, elastin, and hyaluronic acid in skin fibroblasts, which could be added to cosmetics as an effective ingredient for sun protection.…”

“…Talking about diabetes, people are no strangers to it. In the last century, it was relatively rare for people to get diabetes around the age of 40, however, nowadays, diabetes is getting younger and younger in China; the prevalence of type II diabetes has reached 2% among people aged 8–29 and 6.3% among people aged 30–39, and according to research surveys, the number of people with diabetes in China has exceeded 100 million, ranking first in the world (Fu et al, 2021; Y. Zheng et al, 2019). Scientists have found that fungal polysaccharides are effective in lowering blood glucose with minimal side effects, and the use of natural drugs to treat diabetes and lower blood glucose is considered a very promising treatment method because fungal polysaccharides can promote insulin release by inhibiting β‐cell apoptosis, and with insulin, the treatment of type I diabetes will be easily solved (Wińska et al, 2019).…”