<i>Trametes versicolor</i> ethanol extract, a promising candidate for health–promoting food supplement

Janjušević, Ljiljana; Pejin, Boris; Kaišarević, Sonja; Gorjanović, Stanislava; Pastor, Ferenc T.; Tešanović, Kristina; Karaman, Maja

doi:10.1080/14786419.2017.1366484

Cited by 24 publications

(19 citation statements)

References 22 publications

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“…hirsuta and T . versicolor fruiting bodies and mycelia to suppress proliferation of HeLa, LS174 and A549 cell lines in vitro are in accordance with the results obtained by Lau et al [47] and Janjušević et al [49] for ethanolic extract of T . versicolor basidiocarps which IC 50 values for promyeloid leukaemia (HL-60 and NB-4), Burkitt lymphoma (Raji), human breast adenocarcinoma (MCF-7) and liver hepatocellular carcinoma (Hep2G) cell lines were ranged between 123.5 and 269.3 μg/mL.…”

Section: Discussionsupporting

confidence: 91%

Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia

et al. 2018

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In a last few decades mushrooms are increasingly attracting attention as functional food and sources of biologically active compounds. Several Trametes species have been used for centuries in traditional medicine of East Asia cultures, but only T. versicolor was studied sufficiently while there are less substantial data about medicinal properties of other species. Trametes versicolor, T. hirsuta and T. gibbosa were the species tested for biological activities. Antifungal potentials of extracts were assessed for clinical strains of selected Candida and Aspergillus species. ABTS and FRAP assays were used to evaluate antioxidant capacities of studied extracts. Cytotoxic activity was determined against human cervix and lung adenocarcinoma and colon carcinoma cell lines. Antineurodegenerative activity was assessed by determining the rate of acetylcholinesterase and tyrosinase activity. The presence of metabolites in extracts of mycelia and basidiocarps of studied Trametes species was analyzed by 1H NMR spectroscopy. Studied extracts showed low antifungal potential in comparison with ketoconazole. Basidiocarp extracts were more effective ABTS+ scavengers and Fe2+ reducers than mycelium ones but less effective in comparison with L-ascorbic acid. Results showed that mycelium extracts had stronger cytotoxic effects against three cancer cell lines than basidiocarp ones, and that cervix adenocarcinoma cells were the most sensitive to the extracts and commercial cytostatics. T. versicolor mycelium extract was the most effective inhibitor of acetylcholinesterase activity but double weaker than galantamine, and T. gibbosa mycelium extract was significantly better inhibitor of tyrosinase activity than kojic acid for 40.9%. Chemical analysis indicated strong synergistic action of triterpenes, sugars and polyphenols in applied assays. The results suggest that tested Trametes species have significant medicinal potentials which could be attributed to antioxidative and cytotoxic activity. Additionally both, basidiocarps and mycelia extracts can strongly inhibit activity of acetylcholinesterase and tyrosinase.

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Section: Discussionsupporting

confidence: 91%

Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia

et al. 2018

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“…[2,3,5] The H 2 O extract of S. subtomentosum showed the highest SOA scavenging activity (4.1 � 0.2 μg/mL), then, the EtOH extract of T. versicolor (5.0 � 0.3 μg/mL) which activity is better than this from literature data. [28] Investigated extracts showed that species T. versicolor may be a better source of natural antioxidants than S. subtomentosum for which there are no literature data about antioxidative activity.…”

Section: Reducing Power (Frap Assay)mentioning

confidence: 99%

“…[25,26] There is, indeed, a significant positive correlation between antioxidative and antitumor activities, suggesting that oxidative mechanisms lay in the basis of proliferation of tumor cells. [28] Also, hydrogen peroxide (H 2 O 2 ) causes DNA damage through oxygen radical mechanisms that can generate multiple DNA modifications. [4] Compounds with antioxidant potential, may be either simple secondary metabolites (such as, phenolic acids and flavonoids) or highly polymerized compounds (e. g., lignins, melanins, tannins) and inhibit free radicals production or alternatively remove them.…”

Section: Introductionmentioning

confidence: 99%

“…[4] Compounds with antioxidant potential, may be either simple secondary metabolites (such as, phenolic acids and flavonoids) or highly polymerized compounds (e. g., lignins, melanins, tannins) and inhibit free radicals production or alternatively remove them. [28] Most often, extracts that contain more phenolic compounds express better antioxidant and/ or cytotoxic activities. [7] The region of Serbia and the entire Balkan area can be considered as fertile ground for growing and development of diversity of macrofungal species among Basidiomycota and Ascomycota phyla.…”

Section: Introductionmentioning

confidence: 99%

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Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents

Rašeta

Popović

Knežević

et al. 2020

Chemistry & Biodiversity

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Medicinal mushrooms have tremendous potential in production of bioactive compounds with diverse bioactivities while the biochemical potential of some specific mushroom strains (autochthonous for the region) in production of specific bioactive agents may be of the main importance in a continuous search for novel strains with supreme activities all over the world. In this study, the ethanolic (EtOH) and water (H 2 O) extracts of wild-growing polypore mushroom species were investigated: Trametes versicolor (L.) Lloyd and Stereum subtomentosum Pouzar. This study was designed to determine total phenol (TP), flavonoid (TF) and protein content (TPR) as well as LC/MS/MS phenolic profile related to in vitro antioxidant, antiproliferative (MTT assay) (AP) and DNA fragmentation properties. The H 2 O extracts expressed better antioxidant scavenging potential than EtOH showing the highest activity for the T. versicolor (IC 50 = 5.6 μg/mL, IC 50 = 0.6 μg/mL for DPPH * and OH * , respectively) while O 2 *À activity achieved the best activity for S. subtomentosum (IC 50 = 4.1 μg/mL). In contrary, the highest AP activity was obtained for the EtOH extracts of S. subtomentosum (IC 50 = 141.1 μg/mL). The EtOH extracts of both species showed the highest TP, TF and TPR content. Obtained results of DNA degradation indicate genotoxicity potential of the extracts at high concentration. The LC/MS/MS detection showed that the majority of analyzed extracts contained phenolic acids, p-hydroxybenzoic and protocatechuic acid. The obtained results suggest that analyzed medicinal mushroom species, T. versicolor and S. subtomentosum, could be of potential interest as new sources of strong natural antioxidants as well as antiproliferative agents in the future.

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“…Unlike the sample 3, industrial strawberry products (termed exhausted strawberry flesh) did exhibit much higher energy values-310 and 276 kcal/100 g of dry weight, respectively [29]. Though electrochemical assays are often applied on food and beverage samples, that is really not true for HPMC assay and fruit samples of any kind [30][31][32][33][34], in spite of the fact that HPMC actually represents a cheap and time-saving alternative, compared to conventional spectrophotometric and chemiluminescent hydrogen peroxide assays. Additionally, a previously screened sample of the whole strawberry of the Clery cultivar (its polyphenolic extract) did exhibit 2.62-fold lower total antioxidant activity (0.042 ± 0.003 %/µL, determined by the same polarographic assay).…”

Section: Discussionmentioning

confidence: 99%

Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population

et al. 2019

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This study aimed to produce low-energy strawberries of the Joly cultivar by breeding them under different growing conditions. The efficacy of such a process was screened by the means of common physico-chemical parameters underpinned with the findings of elementary chemical analysis. The preferred strawberry breed line (treated with microbiological fertiliser of choice) showed both a decreased energy value (130 ± 6 kJ/100 g or 31.07 kcal) and an increased water content (91.0 ± 7.3 g/100 g). Due to a rich content of phenolic compounds (Total Phenolic Content /TPC/ 4184 ± 39 mg GAE/kg; Total Anthocyanin Content /TAC/ 394 ± 4 mg C3GE/kg), it also exhibited potent antioxidant activity (0.110 ± 0.008 %/μL, HPMC /Hydroxo-Perhydroxyl Mercury(II) Complex/) assay; EC50 = 2.01 ± 0.10 µg and ARP = 0.50 ± 0.05 µg−1, DPPH assay). Finally, the polyphenolic extract of the same breed line showed high anti-α glucosidase activity (IC50 = 19 ± 1 µg/mL), being more than four-fold active compared to acarbose (IC50 = 78 ± 4 µg/mL), the anti-diabetic drug used as a positive control. Taken all together, the utilisation of microbiological fertiliser (Bacillus sp.) in tunnels might be recommended for the breeding of low-energy strawberries of the Joly cultivar (the starting point for developing of novel functional foods targeting the obese population) in the same or similar agricultural conditions, if further studies confirm its likely potential and credibility.

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Trametes versicolor ethanol extract, a promising candidate for health–promoting food supplement

Cited by 24 publications

References 22 publications

Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia

Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia

Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents

Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population

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