<i>TNF‐α</i>Promoter Polymorphisms and Susceptibility to Human Papillomavirus 16–Associated Cervical Cancer

Deshpande, Alina; Nolan, John P.; White, Paul S.; Valdez, Yolanda E.; Hunt, William C.; Peyton, Cheri L.; Wheeler, Cosette M.

doi:10.1086/427826

Cited by 95 publications

(81 citation statements)

References 60 publications

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“…Many previous studies have investigated the TNF À238 and À308 SNPs. [16][17][18][21][22][23][24][25] The number of cases genotyped in the current investigation exceeds all previous studies taken together and we could not detect any association for these polymorphisms.…”

Section: Discussioncontrasting

confidence: 67%

“…17,27,28 In this study, three different sets of haplotypes were evaluated using HaploView; one haplotype covering the polymorphisms in LTA and TNF, and one covering each of TAP1 (corresponding to TAP1 alleles) and TAP2 (TAP2 alleles). In the association analysis of haplotypes, all cases from the family material were used regardless of family structure.…”

Section: Discussionmentioning

confidence: 99%

“…[16][17][18][19][20][21][22][23][24][25] Most studies of TNF as a risk factor for cervical cancer have focused on the -238 and -308 promoter single nucleotide polymorphisms (SNPs). For -238, three of five studies show a protective effect of the A allele 16,21,23 and two studies report no association, 17,24 whereas for -308, six of eight studies showed no association, 16,17,[21][22][23]25 and one study reports an association of the A allele with risk 18 and another study associates the G allele with risk. 24 The TNFa microsatellite, located in the TNF region of MHC class III, showed no association to disease, but the TNFa-11 allele was associated with cervical intraepithelial neoplasia and invasive cervical cancer in Swedish carriers of DQB1*0602.…”

Section: Introductionmentioning

confidence: 99%

“…19,20 In an analysis of 11 SNPs in the TNF, two SNPs in the promoter region showed an association in HPV16-infected Hispanic cervical cancer patients, and one SNP showed an association in non-Hispanic whites. 17 In the LTA gene, two polymorphisms, C804A and A252G, which are in complete linkage disequilibrium (LD), have shown a protective effect that is stronger in squamous cell carcinoma than in adenocarcinoma in a Japanese cohort. 26 The TAP is a heterodimer of TAP1 and TAP2 proteins, which brings cytosolic peptides to the endoplasmic reticulum lumen for association with MHC class I molecules.…”

Section: Introductionmentioning

confidence: 99%

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MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2

Ivansson

Magnusson

et al. 2008

Genes Immun

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Cervical cancer has been associated with specific human leukocyte antigen (HLA) haplotypes/alleles and with polymorphisms at the nearby non-HLA loci TNF, LTA, TAP1 and TAP2. Distinguishing effects of individual loci in the major histocompatibility complex (MHC) region are difficult due to the complex linkage disequilibrium (LD) pattern characterized by high LD, punctuated by recombination hot spots. We have evaluated the association of polymorphism at HLA class II DQB1 and the TNF, LTA, TAP1 and TAP2 genes with cervical cancer risk, using 1306 familial cases and 288 controls. DQB1 was strongly associated; alleles *0301, *0402 and *0602 increased cancer susceptibility, whereas *0501 and *0603 decreased susceptibility. Among the non-HLA loci, association was only detected for the TAP2 665 polymorphism, and interallelic disequilibrium analysis indicated that this could be due to LD with DQB1. As the TAP2 665 association was seen predominantly in non-carriers of DQB1 susceptibility alleles, we hypothesized that TAP2 665 may have an effect not attributable to LD with DQB1. However, a logistic regression analysis suggested that TAP2 665 was strongly influenced by LD with DQB1. Our results emphasize the importance of large sample sizes and underscore the necessity of examining both HLA and non-HLA loci in the MHC to assign association to the correct locus.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2

Ivansson

Magnusson

et al. 2008

Genes Immun

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“…Accordingly, it is rational to speculate that TNF-α -308G>A and -238G>A polymorphisms may have an impact on the development of some types of cancers. In recent years, numerous casecontrol studies have been conducted to investigate the associations of TNF-α -308G>A and -238G>A promoter region polymorphisms with cancer risk, suggesting that these polymorphisms may be associated with cancer susceptibility, such as breast cancer, lung cancer, nasopharyngeal cancer and cervical cancer (Deshpande et al, 2005;Shih et al, 2006;Pooja et al, 2011;Sousa et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Pan¹,

Tian²,

Ji³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Published data on the associations between tumor necrosis factor-alpha (TNF-α) promoter -308G>A and -238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in a fixed/random effect model. 13 separate studies including 3294 cases and 3468 controls were involved in the meta-analysis. We found no association between TNF-α-308G>A polymorphism and cervical cancer in overall population. In subgroup analysis, significantly elevated risks were found in

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Association of HLA‐DRB1, interleukin‐6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population—A candidate gene approach

Castro

Haimila

Sareneva

et al. 2009

Intl Journal of Cancer

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High-risk human papillomavirus (hrHPV) infection is the major risk factor for cervical cancer (CxCa). The role of genetic susceptibility in the disease has been suggested, but the existing data lack consistency. We conducted a nested case-control study on 973 CxCa cases and 1,763 matched controls, from two Swedish population-based cohorts to examine the association of common genetic variants with CxCa risk. Human leukocyte antigen (HLA) alleles and 24 other polymorphisms in 14 genes were selected on the basis of reported association or mechanistic plausibility with an HPV infection or cervical cancer development. Genotyping was conducted using multiplex PCR and Luminex technology. A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] 5 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR 5 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR 5 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele. Additionally, the alleles 0401 and 1501 of the HLA class II DRB1 locus were associated with an increased risk (OR 5 1.23, 95% CI: 1.04-1.45 and OR 5 1.29, 95% CI: 1.11-1.50, respectively), and allele 1301 was associated with decreased risk (OR 5 0.59, 95% CI: 0.47-0.73). The effects of CCND1 and the HLA*DRB1 alleles were independent of the effect of smoking. We did not find any association of risk with polymorphisms in genes related to the innate immune system. In conclusion, our study provides evidence for genetic susceptibility to CxCa due to variations in genes involved in the immune system and in cell cycle. ' UICCKey words: nested case-control study; genetic study; host factors; polymorphisms; human papillomavirus; HPV Cervical cancer (CxCa) is the second most common cancer in women worldwide. It accounts for 250,000 deaths per year and at least 80% of them occur in developing countries.

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TNF‐αPromoter Polymorphisms and Susceptibility to Human Papillomavirus 16–Associated Cervical Cancer

Abstract: We report new associations between several TNF-alpha SNPs and susceptibility to cervical cancer that support the involvement of the TNF- alpha promoter region in development of cervical cancer.

Cited by 95 publications

References 60 publications

MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2

MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2

Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Association of HLA‐DRB1, interleukin‐6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population—A candidate gene approach

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