Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Pan, Feng; Tian, Jing; Ji, Cheng; He, Yong; Han, Xinghua; Wang, Yong; Du, Jianping; Jiang, Fengshou; Zhang, Ying; Pan, Yueyin; Hu, Bing

doi:10.7314/apjcp.2012.13.11.5777

Cited by 30 publications

(15 citation statements)

References 33 publications

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“…The hRAD54 , hMSH2 , ABCB1 , ABCC5 , COL18A1 , and SLC19A1 genes were consistent with lymphoma and leukemia in Latin Americans [153,154,155,156], as well as some Caucasians and Asians [157,158,159,160]. The RB1 gene was related with retinoblastoma in Latin Americans [161,162], and the TNFα and TP53 genes with cervical cancer [163,164,165,166,167,168]. …”

Section: Germline Cancer Predisposition In Latin Americamentioning

confidence: 99%

State of Art of Cancer Pharmacogenomics in Latin American Populations

López‐Cortés

Guerrero

Redal

et al. 2017

IJMS

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Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

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Section: Germline Cancer Predisposition In Latin Americamentioning

confidence: 99%

State of Art of Cancer Pharmacogenomics in Latin American Populations

López‐Cortés

Guerrero

Redal

et al. 2017

IJMS

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“…TNF polymorphism is associated with increased risk of cervical cancer (Liu et al, 2012). Very interestingly TNF-α gene polymorphism can increase or decrease the susceptibility to cervical cancer depending on whether it is TNF-α-238A allele or TNF-α-308G>A which is altered (Pan et al, 2012).…”

Section: Tnfmentioning

confidence: 99%

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Paradkar¹,

Joshi²,

Mertia³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cytokine research is currently at the forefront in cancer research. Deciphering the functions of these multiple small molecules, discovered within the cell and in intercellular spaces, with their abundance and pleotrophism, was initially a great challenge. Advances in analytical chemistry and molecular biology have made it possible to unravel the pathophysiological functions of these polypeptides/proteins which are called interleukins, chemokines, monokines, lymphokines and growth factors. With more than 5 million women contracting cervical cancer every year this cancer is a major cause of mortality and morbidity the world over, particularly in the developing countries. In more than 95% of cases it is associated with human papilloma virus (HPV) infection which is persistent, particularly in those with a defective immune system. Although preventable, the mere magnitude of prevalence of HPV in the world population makes it a dominating current health hazard. The discovery of cytokine dysregulation in cervical cancer has spurted investigation into the possibility of using them as biomarkers in the early diagnosis of cases at high risk of developing cancer. Their critical role in carcinogenesis and progression of cervical cancer is now being revealed to a great extent. From diagnostics to prognosis, and now with a possible role in therapeutics and prevention of cervical cancer, the cytokines are being evaluated in all anticancer approaches. This review endeavours to capture the essence of the astonishing journey of cytokine research in cervical neoplasia.

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“…It has also been demonstrated that basal levels of IL-10 are augmented in the peripheral blood mononuclear cell of patients with SIL [30]. Serum levels of IL-10 were observed to be significantly higher in women with invasive cervical cancer and high grade CIN as compared to controls [5].…”

Section: International Journal Of Medical Research and Reviewmentioning

confidence: 93%

“…In India, the age standardized cervical cancer incidence and mortality rates were 27 and 15 per 100,000 women [4]. Cervical cancer is considered as a complex multi-step, multifactor process, and carcinogenesis occur as a result of multiple gene-environmental interactions [5]. A number of epidemiologic and molecular biologic data revealed that high-risk human papillomavirus (HPV) infection is the most well established environmental risk factor which is confirmed in 95%-100% cases for cervical cancer [6].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of cervical cancer development- a hospital based study

et al. 2015

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Introduction:The present study is an attempt to detect Human papilloma virus infection and immunomodulation status in the development of carcinoma cervix. Methods: Cervical cancer cases were enrolled in between Jan' 2010 to Dec' 2012. Cervical tissue biopsies from the both the cancerous region as well as the non cancerous control area of the cervix, and whole blood (3ml) were collected from all the study subjects. The tissue samples were collected either in PBS or RNA later solution in vials and stored in -80°C or liquid nitrogen till further use. Whole blood (2ml) was also collected from age matched voluntary female community controls (n=50), the plasma was separated, and stored at -20°C for cytokine analysis. Extracted DNA was then checked for presence of HPV DNA by PCR amplification method using MY09/11 primer. Th1 (IL-12) and Th2 (IL-10) were analysed both at protein as well as cervical tissue level. Results:The study showed 83.33% cases found to be HPV positive in cancerous area as well as in non cancerous area. There were other significant risk factor association of cervical cancer with early marriage in 70.36% and high parity 87% of cases. There is alteration of Th1 and Th2 ratio indicating immunomodulation plays an important role in the development of cervical cancer. Conclusion: The human papilloma virus infections are the major contributing factor as well as immunomodulation plays a major role in the development of cervical cancer in our region.

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Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Cited by 30 publications

References 33 publications

State of Art of Cancer Pharmacogenomics in Latin American Populations

State of Art of Cancer Pharmacogenomics in Latin American Populations

Role of Cytokines in Genesis, Progression and Prognosis of Cervical Cancer

Epidemiology of cervical cancer development- a hospital based study

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