<i>TLR2</i>and<i>TLR4</i>polymorphisms influence mRNA and protein expression in colorectal cancer

Proença, Marcela Alcântara; Oliveira, Juliana Garcia de; Cadamuro, Aline Cristina Targa; Succi, Maysa; Netinho, João Gomes; Goloni-Bertolo, Eny Maria; Pavarino, Érika Cristina; Silva, Ana Elizabete

doi:10.3748/wjg.v21.i25.7730

Cited by 29 publications

(33 citation statements)

References 58 publications

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“…Another study reported that the TLR2 del polymorphism is associated with protection from cerebral malaria as a result of an attenuated pro-inflammatory response associated with reduced TLR2 expression. 29 It was also found to be associated with tuberculosis in Caucasians and Africans, 30 colorectal cancer in Brazilians, 31 in breast cancer 32 and in Parkinson 0 s disease in a Greek population. 33 Asian population showing that the TLR2 Ins/Del polymorphism is associated with the risk of severe malaria, 35 cervical cancer, 36,37 gallbladder cancer, 38 prostate cancer, 17,39 Epstein-Barr virus associated gastric carcinoma in Chinese 40,41 and tuberculosis.…”

Section: Discussionmentioning

confidence: 94%

Susceptibility to HIV‐1 infection is influenced by toll like receptor‐2 (−196 to −174) polymorphism in a north Indian population

Vidyant

Chatterjee

Agarwal

et al. 2017

The Journal of Gene Medicine

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Section: Discussionmentioning

confidence: 94%

Susceptibility to HIV‐1 infection is influenced by toll like receptor‐2 (−196 to −174) polymorphism in a north Indian population

Vidyant

Chatterjee

Agarwal

et al. 2017

The Journal of Gene Medicine

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“…Further, F. nucleatum may impact colorectal cancer through TLR4 and TLR2. The stimulation of TLR2/4 results in a selective deletion of miR-18a * and miR-4802 expression, leading to decreased expression of autophagy-related proteins ULK1 and ATG7, and upregulation of miR-34a expression, thereby increasing resistance of colorectal cancer cells to chemotherapy and subsequent progression of cancer (55,56). At the same time, peptidoglycan derived from gram-negative bacteria induces a large number of isolated lymphoid follicles by acting via NOD1 receptors in intestinal epithelial cells.…”

Section: Intestinal Flora Activates the Intestinal Immune Systemmentioning

confidence: 99%

Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract

et al. 2020

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The intestinal tract is the largest digestive organ in the human body. It is colonized by, and consistently exposed to, a myriad of microorganisms, including bifidobacteria, lactobacillus, Escherichia coli, enterococcus, clostridium perfringens, and pseudomonas. To protect the body from potential pathogens, the intestinal tract has evolved regional immune characteristics. These characteristics are defined by its unique structure, function, and microenvironment, which differ drastically from those of the common central and peripheral immune organs. The intestinal microenvironment created by the intestinal flora and its products significantly affects the immune function of the region. In turn, specific diseases regulate and influence the composition of the intestinal flora. A constant interplay occurs between the intestinal flora and immune system. Further, the intestinal microenvironment can be reconstructed by probiotic use or microbiota transplantation, functioning to recalibrate the immune homeostasis, while also contributing to the treatment or amelioration of diseases. In this review, we summarize the relationship between the intestinal flora and the occurrence and development of diseases as an in-turn effect on intestinal immunity. We also discuss improved immune function as it relates to non-specific and specific immunity. Further, we discuss the proliferation, differentiation and secretion of immune cells, within the intestinal region following remodeling of the microenvironment as a means to ameliorate and treat diseases. Finally, we suggest strategies for improved utilization of intestinal flora.

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“…Also, G allele has been reported with a diminished response to the ligands and thus reduced pro-inflammatory cytokine production [60]. This observation led [39] to confirm the lack of association between colorectal cancer development risk and rs4986790 polymorphism. A slight frequency of rs4986790 SNP and absence of G/G homozygous have been associated with CRC in different populations, including in Croatia [61], China [62], Spain [63], Japan [64], Greece [38], Brazil [65], Saudi Arabia [55], and Kashmir [66].…”

Section: • Potential Association Between Tlr4 Polymorphisms and Cancementioning

confidence: 77%

“…Another study investigated the association between rs10759932 C allele polymorphism on CRC development risks and found that there was no influence on TLR4 gene expression in CRC tumor tissue [39]. Furthermore, rs1554973 (T > C) has been associated with improved survival in colon cancer in earlier and advanced stages [42].…”

Section: • Potential Association Between Tlr4 Polymorphisms and Cancementioning

confidence: 99%

Toll-Like Receptors Gene Polymorphism and Susceptibility to Cancer Development

Semlali¹,

Alnemari²,

Almalki³

et al. 2018

Genetic Diversity and Disease Susceptibility

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Toll-like receptors (TLRs) play an important role in immune-surveillance and responses towards pathogenic and non-pathogenic microorganisms. They act as innate immune sensors against endogenous and exogenous danger signals by recognizing the pattern recognition molecules (DAMPs and PAMPs) and drive an adaptive immune response through their signaling pathways, which leads to NF-κB and IRF3 transactivation and induces different inflammatory cytokine genes. TLRs polymorphisms were investigated in various cancer types studies. However, precious studies have reported that the Polymorphisms on TLR1-TLR10 cluster have been associated with increased risk of prostate cancer. However, it has known that TLRs genetic variation is associated with increased the susceptibility to gastric cancer. A same synthetically meta-analysis also confirmed the association of TLRs with increased the gastrointestinal cancer but with decreased prostate cancer risk. Our previous studies have demonstrated a strong link between TLRs polymorphisms and colon cancer and breast cancer in Saudi Arabia population. Similar studies were analyzed with Korean patients with papillary thyroid cancer and their clinic-pathologic features in age matched controls by using direct sequencing. The general objective of this chapter was to investigate the role of different TLRs (i.e., TLR2, TLR4, and TLR6) polymorphisms and their association with cancer development.

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TLR2andTLR4polymorphisms influence mRNA and protein expression in colorectal cancer

Abstract: Our findings suggest that TLR2-196 to -174del polymorphism increases TLR2 mRNA expression and is associated with higher CRC risk, indicating an important role in CRC genetic susceptibility.

Cited by 29 publications

References 58 publications

Susceptibility to HIV‐1 infection is influenced by toll like receptor‐2 (−196 to −174) polymorphism in a north Indian population

Susceptibility to HIV‐1 infection is influenced by toll like receptor‐2 (−196 to −174) polymorphism in a north Indian population

Intestinal Flora and Disease Mutually Shape the Regional Immune System in the Intestinal Tract

Toll-Like Receptors Gene Polymorphism and Susceptibility to Cancer Development

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