Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats

Abstract

Oxidative stress plays an important role in brain dysfunctions induced by alcohol. Since less therapeutic agent against cognitive deficit and brain damage induced by chronic alcohol consumption is less available, we aimed to assess the effect of Tiliacora triandra extract, a plant possessing antioxidant activity, on memory impairment, neuron density, cholinergic function, and oxidative stress in hippocampus of alcoholic rats. Male Wistar rats were induced ethanol dependence condition by semivoluntary intake of alcohol for 15 weeks. Alcoholic rats were orally given T. triandra at doses of 100, 200, and 400 mg·kg−1BW for 14 days. Memory assessment was performed every 7 days while neuron density, activities of AChE, SOD, CAT, and GSH-Px and, MDA level in hippocampus were assessed at the end of study. Interestingly, the extract mitigated the increased escape latency, AChE and MDA level. The extract also mitigated the decreased retention time, SOD, CAT, and GSH-Px activities, and neurons density in hippocampus induced by alcohol. These data suggested that the extract improved memory deficit in alcoholic rats partly via the decreased oxidative stress and the suppression of AChE. Therefore, T. triandra is the potential reagent for treating brain dysfunction induced by alcohol. However, further researches are necessary to understand the detail mechanism and possible active ingredient.

Tiliacora triandra extract possesses antidiabetic effects in high fat diet/streptozotocin‐induced diabetes in rats

“…The rats confirmed as diabetic were further divided into four groups (six rats each): normal control group (NC), diabetic control group (DC), TT‐100 group orally gavage T. triandra extract (100 mg/kg) and TT‐400 group orally gavage with T. triandra extract (400 mg/kg) for 30 days. The selection doses of TT used in this study was according to our preliminary investigation and previous studies (Katisart & Rattana, 2017; Phunchago, Wattanathorn, & Chaisiwamongkol, 2015). The FBG, body weight, daily food, and water intake of all the groups were monitored during the time of treatment.…”

Hypoglycemic Activity of Leaf Extracts from Tiliacora triandra in Normal and Streptozotocin-Induced Diabetic Rats

“…8 Arial part extract of Tiliacora triandra is effective in treating brain dysfunction induced by alcohol and possess anti-tumor and anti-cancer activity. [9][10][11] Alkaloids from Tiliacora triandra also exhibit antimycobacterial activity against multidrug-resistant isolates of Mycobacterium tuberculosis. 12 However, the root extract of this plant contained two pure alkaloid compounds called tiliacorinine and tiliacorine with anti-malarial activity.…”

The Neuroprotective Effects of Carvacrol on Ethanol‐Induced Hippocampal Neurons Impairment via the Antioxidative and Antiapoptotic Pathways

“…The compelling evidence supported that oxidative damage, an important index for evaluating the neuronal injury caused by ethanol, plays a crucial role in neuropathologic lesions [ 37 – 39 ]. Therefore, we speculate that carvacrol partially reversed neuronal injury in the ethanol-induced model by decreasing hippocampal neuronal oxidative stress.…”