Terminalia bellirica fruit extract-mediated synthesis of gold nanoparticles (AuNPs) and studies on antimicrobial and antioxidant activity

Annavaram, Viswadevarayalu; Posa, Venkata Ramana; Lakshmi, Degati Vijaya; Jorepalli, Sumalatha; Somala, Adinarayana Reddy

doi:10.1080/15533174.2016.1212219

Cited by 13 publications

(6 citation statements)

References 23 publications

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“…The inhibition zone was 16 mm and 14 mm for Candida tropicalis and Candida albicans, respectively. 155 14 species of pathogens were tested in the project by Karthika and his co-workers. The pathogens were gram positive (Bacillus subtilis, Staphylococcus aureus, and Streptococcus pneumoniae), gram negative (Escherichia coli, Proteus vulgaris, Shigella dysenteriae, Klebsiella pneumoniae, and Pseudomonas aeruginosa) and fungi (Trichoderma viridae, Fusarium solani, Aspergillus niger, Nigrospora oryzae, Aspergillus fumicatus, and Candida albicans).…”

Section: Gold Nanoparticles As Antimicrobial Agentsmentioning

confidence: 99%

Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications

Lee

Shameli

Yew

et al. 2020

IJN

313

142

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Gold nanoparticles (AuNPs) are extensively studied nanoparticles (NPs) and are known to have profound applications in medicine. There are various methods to synthesize AuNPs which are generally categorized into two main types: chemical and physical synthesis. Continuous efforts have been devoted to search for other more environmental-friendly and economical large-scale methods, such as environmentally friendly biological methods known as green synthesis. Green synthesis is especially important to minimize the harmful chemical and toxic by-products during the conventional synthesis of AuNPs. Green materials such as plants, fungi, microorganisms, enzymes and biopolymers are currently used to synthesize various NPs. Biosynthesized AuNPs are generally safer for use in biomedical applications since they come from natural materials themselves. Multiple surface functionalities of AuNPs allow them to be more robust and flexible when combined with different biological assemblies or modifications for enhanced applications. This review focuses on recent developments of green synthesized AuNPs and discusses their numerous biomedical applications. Sources of green materials with successful examples and other key parameters that determine the functionalities of AuNPs are also discussed in this review.

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Section: Gold Nanoparticles As Antimicrobial Agentsmentioning

confidence: 99%

Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications

Lee

Shameli

Yew

et al. 2020

IJN

313

142

View full text Add to dashboard Cite

show abstract

“…GNPs exhibit a myriad of unique physical, optical, biological and chemical features [3][4][5][6]. Recently, the utilization of GNPs in disease treatment has been examined because research has indicated the capacity of GNPs to target and kill microscopic organisms and tumor cells [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanostars with Reduced Fouling Facilitate Small Molecule Detection in the Presence of Protein

et al. 2021

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Gold nanoparticles have the potential to be used in biomedical applications from diagnostics to drug delivery. However, interactions of gold nanoparticles with different biomolecules in the cellular environment result in the formation of a “protein corona”—a layer of protein formed around a nanoparticle, which induces changes in the properties of nanoparticles. In this work we developed methods to reproducibly synthesize spheroidal and star-shaped gold nanoparticles, and carried out a physico-chemical characterization of synthesized anionic gold nanospheroids and gold nanostars through transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential (ZP), nanoparticles tracking analysis (NTA), ultraviolet-visible (UV–Vis) spectroscopy and estimates of surface-enhanced Raman spectroscopy (SERS) signal enhancement ability. We analyzed how they interact with proteins after pre-incubation with bovine serum albumin (BSA) via UV–Vis, DLS, ZP, NTA, SERS, cryogenic TEM (cryo-TEM) and circular dichroism (CD) spectroscopy. The tests demonstrated that the protein adsorption on the particles’ surfaces was different for spheroidal and star shaped particles. In our experiments, star shaped particles limited the protein corona formation at SERS “hot spots”. This benefits the small-molecule sensing of nanostars in biological media. This work adds more understanding about protein corona formation on gold nanoparticles of different shapes in biological media, and therefore guides design of particles for studies in vitro and in vivo.

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“…It has been shown that the phytochemical constituents present in plants can act as reducing and capping agents during the synthesis biogenic metallic NPs, including gold nanoparticles (AuNPs) [ 3 , 4 ]. Several studies have demonstrated the synthesis of biogenic AuNPs using various species of the genus Terminalia, which include T. catappa , T. chebula , T. arjuna and T. bellirica [ 5 , 6 , 7 , 8 ]. While TM has been used to produce biogenic silver nanoparticles [ 3 ], this species has not been used to produce AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

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Scientists have demonstrated the potential of plant materials as ‘green’ reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less harmful treatment strategies. The current study demonstrated the use of Terminalia mantaly (TM) extracts to synthesize AuNPs with enhanced cytotoxic effects. The TM-AuNPs were synthesized at 25 and 70 °C using water (WTM) and methanolic (MTM) extracts of the leaf, root and stem/bark parts of the plant. The TM-AuNPs were characterized using UV–visible spectrophotometry, dynamic light scattering (DLS), transmission electron microscopy, energy dispersive X-ray (EDX), selection area electron diffraction (SAED) and Fourier transform infrared (FTIR) spectroscopy. Majority of the TM-AuNPs were spherical with a mean diameter between 22.5 and 43 nm and were also crystalline in nature. The cytotoxic effects of TM-AuNPs were investigated in cancer (Caco-2, MCF-7 and HepG2) and non-cancer (KMST-6) cell lines using the MTT assay. While the plant extracts showed some cytotoxicity towards the cancer cells, some of the TM-AuNPs were even more toxic to the cells. The IC50 values (concentrations of the AuNPs that inhibited 50% cell growth) as low as 0.18 µg/mL were found for TM-AuNPs synthesized using the root extract of the plant. Moreover, some of the TM-AuNPs demonstrated selective toxicity towards specific cancer cell types. The study demonstrates the potential of TM extracts to produce AuNPs and describe the optimal conditions for AuNPs using TM extracts. The toxicity of some the TM-AuNPs can possibly be explored in the future as an antitumor treatment.

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Terminalia bellirica fruit extract-mediated synthesis of gold nanoparticles (AuNPs) and studies on antimicrobial and antioxidant activity

Cited by 13 publications

References 23 publications

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

<p>Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications</p>

Gold Nanostars with Reduced Fouling Facilitate Small Molecule Detection in the Presence of Protein

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

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