<i>Taraxacum Officinale</i>Restores Inhibition of Nitric Oxide Production by Cadmium in Mouse Peritoneal Macrophages

Kim, H M; Lee, E H; Shin, Tae‐Yong; Lee, K N; Lee, J S

doi:10.3109/08923979809038545

Cited by 21 publications

(9 citation statements)

References 17 publications

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“…110,137,138 There are also herbal extracts/drugs that enhance the production of NO via iNOS. These drugs [148][149][150][151][152] are generally used as anticancer and antibacterial folk remedies. A classic example is the development of the antineoplastic agent paclitaxel (Taxol; Bristol Myers Squibb, New York, NY, USA) from the dried bark or leaf of Taxus chinesis or Taxus yunnanensis.…”

Section: Plants As Medicine: Traditional Chinese Herbal Medicinementioning

confidence: 99%

Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway

Achike

Kwan

2003

Clin Exp Pharma Physio

118

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SUMMARY Nitric oxide (NO) is formed enzymatically from L -arginine in the presence of nitric oxide synthase (NOS).Nitric oxide is generated constitutively in endothelial cells via sheer stress and blood-borne substances. Nitric oxide is also generated constitutively in neuronal cells and serves as a neurotransmitter and neuromodulator in non-adrenergic, non-cholinergic nerve endings. Furthermore, NO can also be formed via enzyme induction in many tissues in the presence of cytokines.2. The ubiquitous presence of NO in the living body suggests that NO plays an important role in the maintenance of health. Being a free radical with vasodilatory properties, NO exerts dual effects on tissues and cells in various biological systems. At low concentrations, NO can dilate the blood vessels and improve the circulation, but at high concentrations it can cause circulatory shock and induce cell death. Thus, diseases can arise in the presence of the extreme ends of the physiological concentrations of NO.3. The NO signalling pathway has, in recent years, become a target for new drug development. The high level of flavonoids, catechins, tannins and other polyphenolic compounds present in vegetables, fruits, soy, tea and even red wine (from grapes) is believed to contribute to their beneficial health effects. Some of these compounds induce NO formation from the endothelial cells to improve circulation and some suppress the induction of inducible NOS in inflammation and infection.4. Many botanical medicinal herbs and drugs derived from these herbs have been shown to have effects on the NO signalling pathway. For example, the saponins from ginseng, ginsenosides, have been shown to relax blood vessels (probably contributing to the antifatigue and blood pressure-lowering effects of ginseng) and corpus cavernosum (thus, for the treatment of men suffering from erectile dysfunction; however, the legendary aphrodisiac effect of ginseng may be an overstatement). Many plant extracts or purified drugs derived from Chinese medicinal herbs with proposed actions on NO pathways are also reviewed.

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Section: Plants As Medicine: Traditional Chinese Herbal Medicinementioning

confidence: 99%

Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway

Achike

Kwan

2003

Clin Exp Pharma Physio

118

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“…Our Cd intoxication in drinking water (100 mg CdCl 2 /l) increased the superoxide production throughout the experiment. This could correspond to the results obtained by Kim et al (1998), who observed stimulation of IFN- production, an important activator of macrophage's energetic system (Schroder et al, 2004).…”

Section: Discussionmentioning

confidence: 79%

Effect of heavy metal intoxication on macrophage metabolic activity of mice infected with Ascaris suum

Jalčová

2014

Helminthologia

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SummaryThe effect of heavy metal intoxication on superoxide anion (O 2 -) production and larval burden during experimental Ascaris suum infection was studied. Mice were chronically intoxicated with lead (Pb), cadmium (Cd) or mercury (Hg) and subsequently infected with A. suum. The metabolic activity of peritoneal macrophages in mice intoxicated with Pb was suppressed and subsequent parasitic infection did not change this inhibition. Cd intoxication increased the superoxide production and also stimulated the activity of this oxygen radical after A. suum infection. Intoxication with Hg had a stimulative effect on the macrophage metabolic activity and subsequent A. suum infection moderately reduced this activity. Parasite burden was different depending on a type of heavy metal intoxication. Pb intoxication moderately increased the parasite burden in the liver and lungs of intoxicated mice. In contrast, Cd and Hg intoxication triggered a marked reduction of A. suum larvae in the liver and lungs of intoxicated mice, respectively. Monitored heavy metals differed in their immunomodulatory effect on metabolic activity of macrophages what also altered the intensity of the parasite infection in the hosts.

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“…As in Figure 2, rate of WBC in groups 1 (treated with dose of 50 mg/kg), 2 (treated with dose of 100 mg /kg), and 3 (treated with dose of 200 mg/kg) than the control group has increased, but these differences only in group 3 are significant, and as the Figure 3 indicated that rate of lymphocyte in these experimental groups 1, 2, 3 than the control group has increased significantly. The reason of this increasing is due to anti-virus effects [14], antiinflammatory effects [15] and antibacterial effects [16] of this plant. According to Singh study and colleagues in 2008, phenolic compounds in dandelion such as chicoric acid inhibit the penetration of viruses in cells.…”

Section: Resultsmentioning

confidence: 99%

The Effect ofTaraxacum officinaleHydroalcoholic Extract on Blood Cells in Mice

Mahkam

Resalatpour

2012

Advances in Hematology

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Objectives. Dandelion (Taraxacum officinale) is a herbaceous perennial plant of the family Asteraceae and has medicinal and culinary uses. Dandelion has been used as a remedy for anemia, purifing the blood, and providing immune modulation. Therefore, the aim of this study was to investigate the effect of hydro alcoholic extract on blood cells in mice. Methods. Five groups each including ten adult female (Balb/C) mice weighing 30 ± 5 g were chosen. Normal saline was administered as placebo for group, and dandelion hydro alcoholic extract in doses of 50,100, and 200 mg/kg was injected intraperitoneally for 20 days to test groups and the last group was control group.WBC, RBC, HB, HCT, platelet, and other cells were measured with automated cell counter. Main Results. The number of RBC and the rate of HB in three doses of 100 and 200 mg/kg significantly increased (P < 0.05). As compared with control group, the number of WBC in three doses of 50, 100, and 200 mg/kg increased, but it was significantly in 200 mg/kg dandelion treated group as compared with control group(P < 0.05). The rate of platelet in three doses of 50, 100 and 200 mg/kg significantly decreased as compared with control group (P < 0.01). 3 doses of dandelion increased lymphocyte numbers significantly compared with controls. Conclusion. The study indicates efficacy of dandelion extract on RBC and HB in doses of 50, 100, and 200 mg/kg and in 200 mg/kg on WBC to achieve normal body balance.

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Taraxacum OfficinaleRestores Inhibition of Nitric Oxide Production by Cadmium in Mouse Peritoneal Macrophages

Cited by 21 publications

References 17 publications

Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway

Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway

Effect of heavy metal intoxication on macrophage metabolic activity of mice infected with Ascaris suum

The Effect ofTaraxacum officinaleHydroalcoholic Extract on Blood Cells in Mice

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