I¹³¹-Labeled Fat in the Study of Intestinal Absorption

Malabsorption Syndrome and Diabetes Mellitus

“…Triolein fat absorption was less than 1 per cent within six hours 6. Oleic acid uptake was less than 2.1 per cent in six hours 7. These findings are consistent with a state of gastrointestinal malabsorption.…”

Use of labelled triolein, vitamin A, and D-xylose in the diagnosis of malabsorption

“…Thus, an overall 23 % of 78 patients showed dis- cordant results. Using an arbitrary maximum normal faecal loss of 5 %, as suggested by Ruffin, Shingleton, Baylin, Hymans, Isley, Sanders, and Sohmer (1956) and by Cox (1961), only one patient, who had chronic pancreatitis but no steatorrhoea, gave a false positive result with abnormal faecal radioactivity, while 54 % of the 43 patients with steatorrhoea showed normal faecal radioactivity. These false negative results were distributed through all the groups (Table IV).…”

“…The patients with concordant results showed qualitative rather than quantitative correlation, peak values ranging from 1.9 to 58 % in the 'normal' group and from 03 to 17% in patients with faecal fat losses of 10 to 70%. Using values for blood total radioactivity (corrected for total blood volume), and a lower limit of normal of 8% of intake, as suggested by Ruffin et al (1956), 80% of the patients showed results corresponding with their faecal fat loss. Faecal losses and blood peaks of radioactivity showed good negative correlation.…”

Gastrointestinal Absorption with Oleic Acid-I131 and L-Methionine-S35 in Patients with Ulcerative Colitis.

“…As to the increased outputs of nitrogen and of amino acids in the feces of patients with ulcerative colitis, (with intact colons), several observers (6-8) suggested that the increase appears attributable to excess exudate and blood from the colon rather than to unabsorbed proteins. Ruffin et d ( 9 ) studied 8 patients with ulcerative colitis using an 1l3l labeled fat (glycerol trioleate). They reported that the average values of the blood were well within normal limits in each of the 8 patients, as was also the radioactive fat material in the stool.…”