Use of labelled triolein, vitamin A, and D-xylose in the diagnosis of malabsorption

Wormsley, K. G.

doi:10.1136/gut.4.3.261

Cited by 10 publications

(1 citation statement)

References 51 publications

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“…The interpretation of serum retinol concentration following oral administration is not straightforward because there are several steps in the handling of retinol esters which would determine the bioavailability of the molecule once administered. Most of the early work using the ‘vitamin A absorption test’ developed in the 1950s and 1960s used high doses of retinol esters, comparable with the doses used in our study, but clinical and analytical protocols were not standardized and results are difficult to compare from one laboratory to another 18 –20 . Subsequently, it was appreciated that the hepatic retinol store influences the handling of retinol by the liver, so that in a state of repletion retinol is stored in the liver, but in deplete individuals retinol is released for transport by retinol binding protein for use by retinol‐dependent tissues 21 .…”

Section: Discussionmentioning

confidence: 83%

Impaired bioavailability of vitamin A in adults and children with persistent diarrhoea in Zambia

Kelly

Musuku

Kafwembe

et al. 2001

Aliment Pharmacol Ther

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INTRODUCTIONVitamin A is an important micronutrient comprising several retinoids: retinol, retinoic acid, and retinol esters. Its biological activities encompass effects on epithelial integrity and gene transcription, and there is considerable evidence that vitamin A supplementation has important bene®ts for children in the tropics. 1±3 The Zambian population is at high risk of vitamin A de®ciency as demonstrated by low serum retinol concentrations in 20% of adults living in Ndola (E. Kafwembe, unpubl. obs.). The HIV epidemic has had a severe impact on the Zambian population, SUMMARYBackground: We have previously demonstrated a strong relationship between low serum retinol concentration and mortality in Zambian AIDS patients with diarrhoea, but were unable to detect any bene®t from oral micronutrient supplementation. Aim: To test the hypothesis that this is related to impaired availability of vitamin A, we analysed serum retinol concentration changes over 6 h following oral mega-dose therapy (60, 120 or 180 mg retinol). Methods: Twenty-four men without diarrhoea, 15 adults with persistent diarrhoea and 11 children (six girls, ®ve boys) with persistent diarrhoea were studied. Results: Men with persistent diarrhoea had lower baseline serum retinol concentrations (median 0.39 lmol/L, interquartile range 0.21±0.56) than controls (median 1.16 lmol/L, interquartile range 0.84±1.47; P 0.0003). After 60 mg retinol, the rise in serum retinol in HIV seropositive controls (median 0.63 lmol/L, interquartile range 0.35±0.77) did not

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Section: Discussionmentioning

confidence: 83%