<i>Streptococcus suis</i>Meningitis and Bacteremia in Man, French Guiana

Demar, Magalie; Belzunce, Carine; Simonnet, Christine Focquenoy; Renaux, Alain; Abboud, Philippe; Okandze, Antoine; Marois-Créhan, Corinne; Djossou, Félix

doi:10.3201/eid1909.121872

Cited by 8 publications

(2 citation statements)

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“…1 ), and resulted in around 1600 cases of severe human infections. 2 , 8 , 48 In North America (United States 49 , 50 and Canada 51 , 52 ) and the South American countries (Argentina, 53 , 54 Chile, 55 and French Guiana 56 ) only a very few cases of human SS2 infections were reported. Human SS2 infections are featuring with sporadic cases in Europe (Ireland, 3 the United Kingdom [UK], 3 France 3 , , Spain, 57 Netherlands, 58 Belgium, 3 Poland, 61 Sweden, 3 Denmark, 1 Germany, 62 Hungary, 3 Austria, 63 Croatia, 64 Italy 65 - 67 , Greece, 68 and Portugal 1 ), some Asian countries (Laos, 1 Singapore, 33 , 69 India, 2 , 3 , 70 Korea, 71 - 73 Japan, 74 Hong Kong, 75 - 80 Taiwan, 33 , 81 , 82 and Philippine 2 , 3 ), Australia, 83 , 84 and New Zealand.…”

Section: Epidemiology Of S Suis Infectionmentioning

confidence: 99%

Streptococcus suisinfection

et al. 2014

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Streptococcus suis (S. suis) is a family of pathogenic gram-positive bacterial strains that represents a primary health problem in the swine industry worldwide. S. suis is also an emerging zoonotic pathogen that causes severe human infections clinically featuring with varied diseases/syndromes (such as meningitis, septicemia, and arthritis). Over the past few decades, continued efforts have made significant progress toward better understanding this zoonotic infectious entity, contributing in part to the elucidation of the molecular mechanism underlying its high pathogenicity. This review is aimed at presenting an updated overview of this pathogen from the perspective of molecular epidemiology, clinical diagnosis and typing, virulence mechanism, and protective antigens contributing to its zoonosis.

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Section: Epidemiology Of S Suis Infectionmentioning

confidence: 99%

Streptococcus suisinfection

et al. 2014

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“…Since then, this pathogen has spread all over the world. The human Streptococcus suis was epidemic in most Europe countries (3,4), as well as in Asian countries, such as Vietnam and Thailand (5-7). In China, two outbreaks of human streptococcosis have occurred, affecting more than 100 people and causing 39 deaths (8).…”

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Novel Variant Serotype of Streptococcus suis Isolated from Piglets with Meningitis

Pan

Wang³

et al. 2015

Appl Environ Microbiol

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cStreptococcus suis is an emerging zoonotic pathogen causing severe infections in pigs and humans. In previous studies, 33 serotypes of S. suis have been identified using serum agglutination. Here, we describe a novel S. suis strain, CZ130302, isolated from an outbreak of acute piglet meningitis in eastern China. Strong pathogenicity of meningitis caused by strain CZ130302 was reproduced in the BALB/c mouse model. The strain showed a high fatality rate (8/10), higher than those for known virulent serotype 2 strains P1/7 (1/10) and 9801 (2/10). Cell adhesion assay results with bEnd.3 and HEp2 cells showed that CZ130302 was significantly close to P1/7 and 9801. Both the agglutination test and its complementary test showed that strain CZ130302 had no strong cross-reaction with the other 33 S. suis serotypes. The multiplex PCR assays revealed no specified bands for all four sets used to detect the other 33 serotypes. In addition, genetic analysis of the whole cps gene clusters of all serotypes was performed in this study. The results of comparative genomics showed that the cps gene cluster of CZ130302, which was not previously reported, showed no homology to the gene sequences of the other strains. Especially, the wzy, wzx, and acetyltransferase genes of strain CZ130302 are phylogenetically distinct from strains of the other 33 serotypes. Therefore, this study suggested that strain CZ130302 represents a novel variant serotype of S. suis (designated serotype Chz) which has a high potential to be virulent and associated with meningitis in animals. Streptococcus suis causes meningitis and septicemia in pigs and is also known as a zoonotic agent (1). Human infections of S. suis were first reported in Denmark in 1968 (2). Since then, this pathogen has spread all over the world. The human Streptococcus suis was epidemic in most Europe countries (3, 4), as well as in Asian countries, such as Vietnam and Thailand (5-7). In China, two outbreaks of human streptococcosis have occurred, affecting more than 100 people and causing 39 deaths (8). More and more S. suis infections from China, Thailand, Hong Kong, Taiwan, and Singapore have been reported, which indicates that S. suis has been an important cause of adult meningitis, endocarditis, septicemia, and arthritis in Asia (9).The serotyping of S. suis isolates rests on the basis of the antigenicity of their capsular polysaccharides (CPs); 35 serotypes have been identified by agglutination tests (10). With the development of sequence analysis of 16S rRNA and cpn60 genes in S. suis, the original S. suis serotypes 32 and 34 were reclassified as Streptococcus orisratti (11). Phylogenetic analyses of the cps gene cluster, conserved Wzy polymerase, Wzx flippase, and glycosyltransferase are all taken as important means of classifying a novel serotype (12). Multiplex PCR assays against the specific genes of the cps clusters have also been developed to identify serotypes in S. suis (13)(14)(15).From March to May 2013, strain CZ130302 caused an outbreak of streptococcosis in piglets at ...

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Streptococcus suis Deploys Multiple ATP‐Dependent Proteases for Heat Stress Adaptation

Liu,

Wang,

Zhang

et al. 2024

Journal of Basic Microbiology

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Streptococcus suis is an important zoonotic pathogen, causing cytokine storms of Streptococcal toxic shock‐like syndrome amongst humans after a wound infection into the bloodstream. To overcome the challenges of fever and leukocyte recruitment, invasive S. suis must deploy multiple stress responses forming a network and utilize proteases to degrade short‐lived regulatory and misfolded proteins induced by adverse stresses, thereby adapting and evading host immune responses. In this study, we found that S. suis encodes multiple ATP‐dependent proteases, including single‐chain FtsH and double‐subunit Clp protease complexes ClpAP, ClpBP, ClpCP, and ClpXP, which were activated as the fever of infected mice in vivo. The expression of genes ftsH, clpA/B/C, and clpP, but not clpX, were significantly upregulated in S. suis in response to heat stress, while were not changed notably under the treatments with several other stresses, including oxidative, acidic, and cold stimulation. FtsH and ClpP were required for S. suis survival within host blood under heat stress in vitro and in vivo. Deletion of ftsH or clpP attenuated the tolerance of S. suis to heat, oxidative and acidic stresses, and significantly impaired the bacterial survival within macrophages. Further analysis identified that repressor CtsR directly binds and controls the clpA/B/C and clpP operons and is relieved by heat stress. In summary, the deployments of multiple ATP‐dependent proteases form a flexible heat stress response network that appears to allow S. suis to fine‐tune the degradation or refolding of the misfolded proteins to maintain cellular homeostasis and optimal survival during infection.

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Streptococcus suisMeningitis and Bacteremia in Man, French Guiana

Cited by 8 publications

References 9 publications

Streptococcus suisinfection

Streptococcus suisinfection

Novel Variant Serotype of Streptococcus suis Isolated from Piglets with Meningitis

Streptococcus suis Deploys Multiple ATP‐Dependent Proteases for Heat Stress Adaptation

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