<i>Streptococcus suis</i>infection

Feng, Youjun; Zhang, Huimin; Wu, Zhongliang; Wang, Shihua; Cao, Min; Hu, Dan; Wang, Changjun

doi:10.4161/viru.28595

Cited by 181 publications

(141 citation statements)

References 206 publications

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“…According to the differentiation in their bacterial capsule structure, this Streptococcus species is categorized into 35 serotypes (Feng et al. 2010, 2014b). Among them, serotype 2 (SS2) is generally believed to be most virulent, in that it is frequently isolated from clinical diseased swine (Ma et al.…”

Section: Introductionmentioning

confidence: 99%

“…2009; Feng et al. 2014b) and human sporadic cases (Feng et al. 2009b) and/or big‐scale outbreaks (Tang et al.…”

Section: Introductionmentioning

confidence: 99%

“…We are aware that SS2 has spread to more than 30 countries/regions and claims nearly 1600 cases of human infections worldwide (Feng et al. 2014b). The molecular mechanism underlying bacterial pathogenicity has been partially delineated thus far (Feng et al.…”

Section: Introductionmentioning

confidence: 99%

“…The molecular mechanism underlying bacterial pathogenicity has been partially delineated thus far (Feng et al. 2014b), and these identified virulence determinants include the previously‐known virulence factors exemplified with capsule (Benga et al. 2008; Seitz et al.…”

Section: Introductionmentioning

confidence: 99%

“…to bacterial pathogenesis (Feng et al. 2014b). However, nothing is aware regarding the potential relevance of bacterial GalN/GalNAc metabolism and/or its regulation to S. suis infection.…”

Section: Introductionmentioning

confidence: 99%

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Two novel regulators of N‐acetyl‐galactosamine utilization pathway and distinct roles in bacterial infections

Zhang

Ravcheev

et al. 2015

MicrobiologyOpen

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Bacterial pathogens can exploit metabolic pathways to facilitate their successful infection cycles, but little is known about roles of d‐galactosamine (GalN)/N‐acetyl‐d‐galactosamine (GalNAc) catabolism pathway in bacterial pathogenesis. Here, we report the genomic reconstruction of GalN/GalNAc utilization pathway in Streptococci and the diversified aga regulons. We delineated two new paralogous AgaR regulators for the GalN/GalNAc catabolism pathway. The electrophoretic mobility shift assays experiment demonstrated that AgaR2 (AgaR1) binds the predicted palindromes, and the combined in vivo data from reverse transcription quantitative polymerase chain reaction and RNA‐seq suggested that AgaR2 (not AgaR1) can effectively repress the transcription of the target genes. Removal of agaR2 (not agaR1) from Streptococcus suis 05ZYH33 augments significantly the abilities of both adherence to Hep‐2 cells and anti‐phagocytosis against RAW264.7 macrophage. As anticipated, the dysfunction in AgaR2‐mediated regulation of S. suis impairs its pathogenicity in experimental models of both mice and piglets. Our finding discovered two novel regulators specific for GalN/GalNAc catabolism and assigned them distinct roles into bacterial infections. To the best of our knowledge, it might represent a first paradigm that links the GalN/GalNAc catabolism pathway to bacterial pathogenesis.

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Section: Introductionmentioning

confidence: 99%

“…2009; Feng et al. 2014b) and human sporadic cases (Feng et al. 2009b) and/or big‐scale outbreaks (Tang et al.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…to bacterial pathogenesis (Feng et al. 2014b). However, nothing is aware regarding the potential relevance of bacterial GalN/GalNAc metabolism and/or its regulation to S. suis infection.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Two novel regulators of N‐acetyl‐galactosamine utilization pathway and distinct roles in bacterial infections

Zhang

Ravcheev

et al. 2015

MicrobiologyOpen

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The involvement of MsmK in pathogenesis of the Streptococcus suis serotype 2

et al. 2017

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Streptococcus suis serotype 2 (SS2) is an important swine and human pathogen that causes global economic and public health problems. Virulent S. suis strains successfully maintain high bacterial concentrations in host blood and rapidly adapt to challenging environments within hosts. Successful survival in hosts is a major factor influencing the pathogenesis of SS2. We have previously identified that SS2 colonization in mouse brain is possibly affected by the ATPase, MsmK of carbohydrate ATP‐binding cassette (ABC) transporters because of carbohydrate utilization. In this study, the chain length of the msmK deletion mutant was longer than that of the wild type, and the former was significantly more susceptible than the latter when theses strains were exposed to mouse blood both in vivo and in vitro. The hemolytic activity of the mutant strain was decreased. Although the adhesion of the mutant to HEp‐2 cell lines was enhanced, the deletion of msmK impaired the abilities of SS2 to resist phagocytosis and survive severe stress conditions. MsmK contributed to the survival and adaptation of SS2 in host bloodstream. Therefore, MsmK was identified as a multifunctional component that not only contributed to carbohydrate utilization but also participated in SS2 pathogenesis.

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