<i>Staphylococcus aureus</i> Infections in Children: The Implications of Changing Trends

“…The reason for the decline in methicillin resistance in community-associated infections reported in multiple centers in the U.S. in the last decade is not known, but such information could be of use in the development of strategies to prevent CA-MRSA infections. [26]…”

Section: Discussionmentioning

confidence: 99%

A decade of antimicrobial resistance in Staphylococcus aureus: A single center experience

et al. 2019

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Background The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) resulted in the recommended use of clindamycin and trimethoprim-sulfamethoxazole (TMP-SMX) for suspected S . aureus infections. The objective of this study was to determine the resistance to methicillin, clindamycin, and TMP-SMX in S . aureus isolates during a 10-year period. Methods Retrospective review of the antimicrobial susceptibilities of all S . aureus isolates in the outpatient and inpatient settings at Nationwide Children’s Hospital from 1/1/2005 to 12/31/2014. Duplicate isolates from the same site and year and those obtained for MRSA surveillance or from patients with cystic fibrosis were excluded. Results Of the 57,788 S . aureus isolates from 2005–2014, 40,795 (71%) were included. In the outpatient setting, methicillin resistance decreased from 54% to 44% ( p <0.001) while among inpatient isolates, no significant change was observed. From 2009–2014, resistance to clindamycin among outpatient isolates increased from 16% to 17% ( p = 0.002) but no significant trend was observed among inpatient isolates (18% to 22%). Similarly, TMP-SMX resistance increased in outpatient S . aureus isolates from 2005–2014 (0.9% to 4%, p <0.001) but not among inpatient isolates. Among both inpatient and outpatient isolates, methicillin-susceptible S . aureus (MSSA) exhibited higher resistance to both clindamycin and TMP-SMX than MRSA. In addition, resistance to methicillin, clindamycin and TMP-SMX varied widely according to the site of specimen collection. Conclusion In a decade where >40,000 S . aureus isolates were identified at a large pediatric hospital, substantial changes in methicillin, clindamycin, and TMP-SMX resistance occurred. These findings highlight the importance of ongoing surveillance of the local antimicrobial resistance in S . aureus in order to guide empiric antimicrobial therapy.

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“…A data extraction form was designed to extract the following variables: (1) first author, (2) year of publication, (3) number of investigated patients, (4) number of S. aureus-infected individuals, (5) number of MRSA-infected individuals, (6) research environment, (7) MRSA diagnostic method, and (9) study location (province).…”

Section: Data Extractionmentioning

confidence: 99%

Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis

et al. 2021

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This study aimed to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Iranian children. International databases, including Web of Science, PubMed, Embase, and Scopus, and Iranian databases, including Scientific Information Database (www.sid.ir), Magiran, and Iranian Database for Medical Literature (idml.research.ac.ir), were systematically searched for articles published between January 2000 and August 2019. Sources of heterogeneity were determined using subgroup analysis and meta-regression. Overall, 343 studies were identified; of them, 20 were included in the meta-analysis to estimate the pooled prevalence. The pooled prevalence of MRSA was 42% (95% confidence interval [CI], 29-55%) among culture-positive cases of S. aureus, 51% (95% CI, 39-62%) in hospitalized children, and 14% (95% CI, 0.05-27%) in healthy children. The overall pooled prevalence of MRSA in children was 42%. Appropriate infection control measures and effective antibiotic therapy are needed.

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Staphylococcus aureus Infections in Children: The Implications of Changing Trends

Cited by 12 publications

References 10 publications

Antibiotic Resistance Among Pediatric-Sourced Ocular Pathogens: 8-Year Findings From the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) Surveillance Study

Antibiotic Resistance Among Pediatric-Sourced Ocular Pathogens: 8-Year Findings From the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) Surveillance Study

A decade of antimicrobial resistance in Staphylococcus aureus: A single center experience

Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis

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