<i>Staphylococcus argenteus</i>
            Infections, Brazil

Balzan, Lisiane da Luz Rocha; Rossato, Adriana Medianeira; Riche, Cezar Vinícius Würdig; Cantarelli, Vlademir Vicente; d’Azevedo, Pedro Alves; Andrade-Lima, Aluísio; Rodrigues, Beatriz Quental; Silva, Ivan Leonardo Avelino França e; Dias, Cícero Armídio Gomes; Sampaio, Julliane Messias Cordeiro

doi:10.1128/spectrum.01179-22

Cited by 2 publications

(4 citation statements)

References 10 publications

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“…Both ST-2250 and ST-1223 were confirmed as the predominant genotypes in Hong Kong. Additionally, the ST-2250 strain was also identified in other Asian cities, where it caused various forms of infections [6,8,20,21,24]. The ST-1223 is another emerging genotype that has associations with human infections.…”

Section: Discussionmentioning

confidence: 99%

“…It was later proposed to become a new species in 2015 [4]. An increasing number of cases have been reported in different countries across Oceania, Africa, America, Asia, and Europe between 2015-2023 [5][6][7][8][9][10]. Southeast Asia, the Amazon, and remote regions in Australia have shown a high prevalence of S. argenteus [11].…”

Section: Introductionmentioning

confidence: 99%

“…According to the PubMLST database, over 60 MLST types of S. argenteus have been reported in different geographical regions, with the ST-2250 variant being most frequently reported genotype [11]. Other MLSTs, including ST-1223, ST-1850, ST-2198, ST-2793, ST-2854, and ST-3261, have also been associated with human infections worldwide [8,9,12,21,31,[35][36][37][38][39][40]. Different MLST genotypes carry distinct virulence genes and antimicrobial resistance (AMR) genes [40].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Chen,

Leung,

Wong

et al. 2023

Microorganisms

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Staphylococcus argenteus is a novel Staphylococcus species derived from Staphylococcus aureus. Information on the prevalence and genetic characteristics of invasive S. argenteus in Asia is limited. In this study, 275 invasive S. aureus complex strains were retrieved from blood culture specimens in Hong Kong and re-analyzed using MALDI-TOF mass spectrometry and an in-house multiplex real-time PCR for S. argenteus. The prevalence of invasive S. argenteus in Hong Kong was found to be 4.0% (11/275). These strains were primarily susceptible to commonly used antibiotics, except penicillin. Whole-genome sequencing revealed the circulation of three S. argenteus genotypes (ST-2250, ST-1223, and ST-2854) in Hong Kong, with ST-2250 and ST-1223 being the predominant genotypes. The local ST-2250 and ST-1223 strains showed close phylogenetic relationships with isolates from mainland China. Antimicrobial-resistant genes (fosB, tet-38, mepA, blaI, blaZ) could be found in nearly all local S. argenteus strains. The ST-1223 and ST-2250 genotypes carried multiple staphylococcal enterotoxin genes that could cause food poisoning and toxic shock syndrome. The CRISPR/Cas locus was observed only in the ST-2250 strains. This study provides the first report on the molecular epidemiology of invasive S. argenteus in Hong Kong, and further analysis is needed to understand its transmission reservoir.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Chen,

Leung,

Wong

et al. 2023

Microorganisms

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“…[3] Subsequently, several studies reported sporadic cases of infections caused by S argenteus in Asia, Oceania, the Pacific Islands, Latin America, Europe, and Africa. [3–6] Here, we describe a fatal case of bacteremia caused by S argenteus isolated from bloodstream of a comatose patient.…”

Section: Introductionmentioning

confidence: 99%

Fatal bacteremia caused by Staphylococcus argenteus: A case report

Zhan,

Tang,

Zhang

et al. 2023

Medicine

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Rationale: Staphylococcus argenteus (S argenteus) is a novel and emerging species that is part of the Staphylococcus aureus (S aureus) complex. Fatal cases of bloodstream infection caused by S argenteus are rarely reported and should be considered in medical practice. Patient concerns: A 44-year-old male was admitted to our hospital with reduced appetite, high fever and unconsciousness. Laboratory tests indicated infection, muscle damage, and alkalosis in the patient. Brain computed tomography (CT) demonstrated small hematoma in left frontal lobe with peripheral cerebral edema. Chest CT demonstrating chronic bronchitis, emphysema, and bullae in the right lung. Blood culture was collected on the first day of hospitalization for microbial culture and pathological examination. Diagnosis: The isolate from blood culture was identified as S argenteus by MALDI-TOF MS after the patient death. Interventions: The patient was subjected to empirical antibiotic treatment with piperacillin/tazobactam. Outcomes: After 48 hours of hospitalization, the patient died after ineffective rescue. Lessons: The patient had long-term heavy drinking and smoking as well as chronic malnutrition, which may account for his immune deficiency. The immunocompromised people are more vulnerable to infection by S argenteus and then develop bacteremia. The use of piperacillin/tazobactam may have contributed to the patient death.

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Staphylococcus argenteus Infections, Brazil

Cited by 2 publications

References 10 publications

Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Prevalence and Characteristics of Invasive Staphylococcus argenteus among Patients with Bacteremia in Hong Kong

Fatal bacteremia caused by Staphylococcus argenteus: A case report

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