Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin

Abstract

Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and contains substantial amounts of polyphenols. In this study, we evaluated the therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides farinae body (Dfb)-induced atopic dermatitis (AD). The ethanol extract of the peel of JY (EPJ) ameliorated Dfb-induced dermatitis severity, serum levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine. Histological analysis of the skin also revealed that EPJ treatment significantly decreased mast cell infiltration. The suppression of dermatitis by EPJ treatment was accompanied by a decrease in the skin levels of type 2 helper T-cell cytokines such as interleukin (IL)-4, IL-5, and IL-13. The induction of thymic stromal lymphopoietin, which leads to a systemic Th2 response, was also decreased in the skin by EPJ. Nuclear translocation of nuclear factor-κB p65 was decreased by EPJ in Dfb-induced NC/Nga mice. The protein expression of filaggrin in the AD-like skin lesions was restored by EPJ treatment. These results suggested that EPJ may be a potential therapeutic tool for the treatment of AD.

Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway

“…The loss of the immunological balance between Th1 and Th2 cells is one of major pathogenic events occurring in AD [39]. Acute AD skin lesions exhibit Th2-dominant responses characterized by dermal infiltration of CD4 + or CD8 + T cells and eosinophils, as well as upregulated skin expression of Th2 cytokines [40]. However, Th1 responses are characterized by the production of effector cytokines, such as TNF- α and IFN- γ .…”

Phenolic compounds in potato (Solanum tuberosum L.) peel and their health‐promoting activities

“…PP extract contained the highest phenolic content with potential antioxidant and antidiabetic properties (Arun et al ., ). The ethanol extract of PP obtained from coloured potato cultivar (Jayoung) showed an inhibitory effect against the development of atopic dermatitis in a mouse model (Yang et al .,). It can be used as a safe and effective therapeutic tool for the treatment of atopic dermatitis.…”

Inhibitory Effects of Helianthus tuberosus Ethanol Extract on Dermatophagoides farina body-induced Atopic Dermatitis Mouse Model and Human Keratinocytes

“…Clinical dermatitis severity was evaluated using the method according to the scoring system [ 13 ] as follows: The severity of dermatitis was evaluated from the start to the end of the experiment. The development of skin symptoms, erythema/hemorrhage, scarring/dryness, edema, and excoriation/erosion, was scored as follows: 0, none; 1, mild (<20%); 2, moderate (20–60%); or 3, severe (>60%).…”