<i>SMARCA5</i>Methylation and Expression in Gastric Cancer

Gigek, Carolina Oliveira; Lisboa, Luara Carolina Frias; Leal, Mariana Ferreira; Silva, Patricia Natalia Oliveira; Lima, Eleonidas Moura; Khayat, André Salim; Assumpção, Paulo Pimentel de; Burbano, Rommel Rodrı́guez; Smith, Marı́lia de Arruda Cardoso

doi:10.3109/07357907.2010.543365

Cited by 41 publications

(26 citation statements)

References 26 publications

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“…The protein is mainly involved in chromatin remodeling and regulation of transcription. Its deregulation has been described in gastric cancer [79]. More recently the possibility of SMARCA5 to produce a fusion transcript in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor has been described.…”

Section: Ews Translocation Partners In Cancermentioning

confidence: 99%

Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors

et al. 2013

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Soft tissue tumors are a heterogeneous group of tumors, traditionally classified according to morphology and histogenesis. Molecular classification divides sarcomas into two main categories: (a) sarcomas with specific genetic alterations and (b) sarcomas showing multiple complex karyotypic abnormalities without any specific pattern. Most chromosomal alterations are represented by translocations which are increasingly detected. The identification of fusion transcripts, in fact, not only support the diagnosis but also provides the basis for the development of new therapeutic strategies aimed at blocking aberrant activity of the chimeric proteins. One of the genes most susceptible to breakage/translocation in soft tissue tumors is represented by Ewing sarcoma breakpoint region 1 (EWSR1). This gene has a large number of fusion partners, mainly associated with the pathogenesis of Ewing’s sarcoma but with other soft tissue tumors too. In this review, we illustrate the characteristics of this gene/protein, both in normal cellular physiology and in carcinogenesis. We describe the different fusion partners of EWSR1, the molecular pathways in which is involved and the main molecular biology techniques for the identification of fusion transcripts and for their inhibition.

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Section: Ews Translocation Partners In Cancermentioning

confidence: 99%

Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors

et al. 2013

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“…Finally, 34 studies lacked usable data that correlated telomerase or hTERT with lymph node status or TNM stage to create 2x2 tables. Thus, a total of 18 eligible studies related to GC patients were finally identified in our meta-analysis with good agreement between reviewers (κ=0.73) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) (Fig. 1).…”

Section: Selection and Characteristics Of The Studiesmentioning

confidence: 99%

“…Although research was conducted at tertiary referral centers, almost all studies were performed in Asia and one in South America (22). Sample size varied from 20 to 95 participants, and the average age across all of the studies was 59.3 years, with a variation ranging from 32 to 89 years.…”

Section: Selection and Characteristics Of The Studiesmentioning

confidence: 99%

Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis

Lü

Deng²,

Cao

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. Activation of telomerase is involved in carcinogenesis in most types of cancers. However, the prognostic value of telomerase activity (TA) in patients with gastric carcinoma (GC) remains controversial. We conducted a meta-analysis to assess the relationship between TA and the clinical outcome of GC. A meta-analysis of 18 studies (886 patients) was performed to evaluate the association between TA and metastasis-related parameters in GC patients by searching databases, including PubMed, MEDLINE, EMBASE, Web of Science databases, Cochrane Library and the Chinese Biomedical Literature database (CBM) (last search updated in October 2011). We used the odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association between TA and metastasis of GC. Our analysis results indicated that high telomerase activity expression tended to be associated with the presence of lymph node metastasis (866 patients) (OR=2.03, 95% CI 1.21-3.39, p=0.007), the depth of invasion (886 patients) (OR=1.87, 95% CI 1.30-2.70, p=0.0007), distant metastasis (407 patients) (OR=2.71, 95% CI 1.59-4.63, p=0.0002), tumor size (466 patients) (OR=2.14, 95% CI 1.31-3.50, p=0.002) and TNM stage (711 patients) (OR=2.39, 95% CI 1.30-4.41, p=0.005). However, high TA expression was not associated with the presence of histologic differentiation (791 patients) (OR=1.51, 95% CI 0.73-3.11, p=0.26). In conclusion, telomerase overexpression not only plays a key role in primary initiation, but also promotes invasion and metastatic progression of GC.These findings raise the possibility of using TA to screen for the prognosis of gastric cancer.

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“…More recently, SNF2H was identified as a fusion partner of EWSR1 in Ewing sarcoma/primitive neuroectodermal tumors, and the tumorigenic potential of the chimeric protein was documented (46). Furthermore, higher levels of SNF2H have been reported in gastric cancer than in normal mucosa, suggesting a role in malignancy (17).…”

mentioning

confidence: 99%

Nucleosome Remodeler SNF2L Suppresses Cell Proliferation and Migration and Attenuates Wnt Signaling

Eckey

Kuphal

Straub

et al. 2012

Molecular and Cellular Biology

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ISWI is an evolutionarily conserved ATPase that catalyzes nucleosome remodeling in different macromolecular complexes. Two mammalian ISWI orthologs, SNF2H and SNF2L, are thought to have specialized functions despite their high sequence similarity. To date, the function of SNF2L in human cells has not been a focus of research. Newly established specific monoclonal antibodies and selective RNA interference protocols have now enabled a comprehensive characterization of loss-of-function phenotypes in human cells. In contrast to earlier results, we found SNF2L to be broadly expressed in primary human tissues. Depletion of SNF2L in HeLa cells led to enhanced proliferation and increased migration. These phenomena were explained by transcriptome profiling, which identified SNF2L as a modulator of the Wnt signaling network. The cumulative effects of SNF2L depletion on gene expression portray the cell in a state of activated Wnt signaling characterized by increased proliferation and chemotactic locomotion. Accordingly, high levels of SNF2L expression in normal melanocytes contrast with undetectable expression in malignant melanoma. In summary, our data document an inverse relationship between SNF2L expression and features characteristic of malignant cells.

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SMARCA5Methylation and Expression in Gastric Cancer

Cited by 41 publications

References 26 publications

Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors

Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors

Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis

Nucleosome Remodeler SNF2L Suppresses Cell Proliferation and Migration and Attenuates Wnt Signaling

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