<i>Simultaneous Measurement of Plasma Volume in Man With T-1824 and an Improved I<sup>131</sup>-Albumin Method</i>

Franks, J. J.; Zizza, Frank

doi:10.1152/jappl.1958.13.2.299

Cited by 16 publications

(1 citation statement)

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“…The distribution space of T-1824 compared with labelled protein has been reported to be greater by 9% in humans (Rodnan, 1956), dogs (Baker and Wycoff, 1961;Baker, 1963) and mice (Wish, Furth and Storey, 1950) and seems to be due to the faster rate of removal of T-1824 from the circulation (Gregersen, Boyden and Alison, 1950;Franks and Zizza, 1958;Baker and Wycoff, 1961).…”

Section: Plasma Volumementioning

confidence: 99%

DISTRIBUTION VOLUMES OF LABELLED RED BLOOD CELLS AND LABELLED PROTEIN AND “F CELLS” IN INTACT AND SPLENECTOMIZED HbA AND HbB TYPE SHEEP

Dooley

Morris

Harris

1971

Aust J Exp Biol Med

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Summary. The dilutions of labelled red blood cells and labelled albumin were studied over a 10 hour period in HbA and HbB sheep, both before and after splenectomy.The dilution curves were analysed into exponentials, and values for red blood cell volume and plasma volume were calculated from various portions of the curves.Dilution curves for labelled red blood cells in intact sheep showed important differences from those in splenectomized sheep.Red blood cell volume was calculated from: The extrapolation of the exponential process with the slowest decay rate; the sum of intercepts of all exponential processes; jugular haematocrit and plasma volume. Splenectomy significantly reduced the values for these parameters.Plasma volume was calculated from the extrapolation of the exponential with the slowest decay rate and from the sum of intercepts of all exponential processes. Splenectomy significantly reduced the values for these parameters.Blood volume and the value for the ratio of body to jugular haematocrit were calculated from the data, and were found to be significantly reduced by splenectomy.Diiferences between HbA and HbB sheep were found only for jugular haematocrit and red blood cell volume calculated from jugular haematocrit and plasma volume.The differences in values from the several methods of calculating red blood cell volume in intact sheep and the reduction of these values by splenectomy are discussed in relation to the splenic red blood cell content.

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Section: Plasma Volumementioning

confidence: 99%

DISTRIBUTION VOLUMES OF LABELLED RED BLOOD CELLS AND LABELLED PROTEIN AND “F CELLS” IN INTACT AND SPLENECTOMIZED HbA AND HbB TYPE SHEEP

Dooley

Morris

Harris

1971

Aust J Exp Biol Med

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Plasma Volume Changes in the Neonate

Steele¹

1962

Arch Pediatr Adolesc Med

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The primary objective of this study was to demonstrate shifts of plasma between vascular and extravascular spaces during the first 2\m=1/2\ hours of life. Such shifts in plasma volume have been postulated by Marks et al. in order to account for the significant rise in packed cell volume that they demonstrated within the first 2\m=1/2\hours of life.1 Plasma volume was measured by human serum-albumin-bound iodine131 (Risa, Abbott Laboratories). Since, to date, this agent has not been used for this purpose in newborn infants, a demonstration of its effectiveness was the second major objective. A third objective of this study was to relate the early changes occurring in the blood compartments to the pathogenesis of hyaline membrane disease. For this purpose, infants born by Cesarean section were compared with infants born by normal vaginal delivery. Materials and MethodNine normal newborns and 9 elective Cesarean section infants were studied. The normal newborns were selected at random from the ward population of the Grace-New Haven Community Hospital. Elective Cesarean section infants were selected at random from the private and ward services of the Grace-New Haven Community Hospital. The only indication for Cesarean section in all cases was a previous Cesarean section.The cord was not touched. After one minute, the cord was clamped and cut. In the Cesarean section group, after the head and body were completely delivered, the baby was laid across the mother's legs for one minute. The cord was not touched. After one minute, the cord was clamped and cut. The patient was then transferred to a warm Armstrong incubator and evaluated by a member of the pediatrie house staff. If, after 5 minutes had passed, the baby was in good condition, it was accepted for the study.All Cesarean sections were performed under spinal or epidural anesthesia. Vaginal deliveries were performed under either local anesthesia or a combination of local anesthesia with nitrous oxide. In one case, cyclopropane was given. In many instances, in both the vaginal and Cesarean section groups, forceps were used to assist delivery.Using sterile technique, the umbilical cord was cut approximately 2 cm. from its base, and the umbilical vein was located and cannulated for 4 to 6 cm. with a sterile No. 5 French polyethylene infant feeding tube, which had been filled with heparinized saline. Via a 3-way stopcock, 8 cc. of blood were drawn into a heparinized syringe. Then, using a graduated standard 2 cm. syringe, approximately 0.04/iC of human serum-albuminbound iodine131 was injected into the umbilical catheter and flushed in with 4 cc. of blood from the heparinized syringe. The 2 cc. syringe was then rinsed 4 times with blood from the baby, and, finally, the entire system was rinsed and flushed into the baby with the remaining 4 cc. of heparin¬ ized blood. The polyethylene catheter was left in the umbilical vein. Five minutes after in¬ jection, mixing was assumed to be complete, and blood was removed for analysis. In order to flush 0 hr., 15 min. 2 hr., 15 m...

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Red cell volume and jaundice in premature infants

et al. 1970

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Simultaneous Measurement of Plasma Volume in Man With T-1824 and an Improved I¹³¹-Albumin Method

Cited by 16 publications

References 0 publications

DISTRIBUTION VOLUMES OF LABELLED RED BLOOD CELLS AND LABELLED PROTEIN AND “F CELLS” IN INTACT AND SPLENECTOMIZED HbA AND HbB TYPE SHEEP

DISTRIBUTION VOLUMES OF LABELLED RED BLOOD CELLS AND LABELLED PROTEIN AND “F CELLS” IN INTACT AND SPLENECTOMIZED HbA AND HbB TYPE SHEEP

Plasma Volume Changes in the Neonate

Red cell volume and jaundice in premature infants

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Simultaneous Measurement of Plasma Volume in Man With T-1824 and an Improved I131-Albumin Method

Cited by 16 publications

References 0 publications

DISTRIBUTION VOLUMES OF LABELLED RED BLOOD CELLS AND LABELLED PROTEIN AND “F CELLS” IN INTACT AND SPLENECTOMIZED HbA AND HbB TYPE SHEEP

DISTRIBUTION VOLUMES OF LABELLED RED BLOOD CELLS AND LABELLED PROTEIN AND “F CELLS” IN INTACT AND SPLENECTOMIZED HbA AND HbB TYPE SHEEP

Plasma Volume Changes in the Neonate

Red cell volume and jaundice in premature infants

Contact Info

Product

Resources

About

Simultaneous Measurement of Plasma Volume in Man With T-1824 and an Improved I¹³¹-Albumin Method