SERPINA1 gene expression in whole blood links the rs6647 variant G allele to an increased risk of large artery atherosclerotic stroke

Abstract

The rs6647 variant G allele in SERPINA1 gene was reported to be associated with the risk of large artery atherosclerotic stroke (LAS), however, the mechanism remains unclear. Here, we performed a functional annotation of the rs6647 variant by using the software HaploReg version 4.1 (HaploReg v4.1). Next, the expression quantita

Ischemic Stroke and Sleep: The Linking Genetic Factors

“…SERPINE1 activation can exacerbate apoptosis and inflammation, contributing to progression of stroke injury [ 188 ] and can also be associated with arterial remodeling and atherosclerosis progression. It is supposed to be specific to large-artery subtype of ischemic stroke [ 189 ], and patients with large-artery ischemic stroke demonstrate higher expression of the SERPINE1 gene compared to healthy controls [ 190 ].…”