<i>Sambucus nigra</i> L. Fruits and Flowers: Chemical Composition and Related Bioactivities

Ferreira, Sandrine S.; Silva, Amélia M.; Nunes, Fernando M.

doi:10.1080/87559129.2020.1788578

Cited by 47 publications

(65 citation statements)

References 71 publications

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“…In a review, Ferreira et al [13] reported variations in antioxidant activity of some elderflower extracts, and justifies these differences by plant growth conditions, post-harvest storage, extraction techniques, antioxidant evaluation test, etc., which may also explain the differences among our results.…”

Section: Phenolic Content and Antioxidant Activitymentioning

confidence: 95%

“…This claim is supported by other researchers who previously demonstrated that aqueous extracts of the S. nigra flower have a high antioxidant activity by different mechanisms of action evaluated from various methods (DPPH, FRAP, ABTS, etc.) [13,34,37]. For example, in a study by Viapiana et al [34] the infusions of S. nigra L. flower extracts showed a radical scavenging activity by the DPPH method between 0.57-0.92 mmol TE/g of dry flower.…”

Section: Phenolic Content and Antioxidant Activitymentioning

confidence: 98%

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Chemical Characterization of Sambucus nigra L. Flowers Aqueous Extract and Its Biological Implications

et al. 2021

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The main goal of this study was to chemically characterize an aqueous S. nigra flower extract and validate it as a bioactive agent. The elderflower aqueous extraction was performed at different temperatures (50, 70 and 90 °C). The extract obtained at 90 °C exhibited the highest phenolic content and antiradical activity. Therefore, this extract was analyzed by GC-MS and HPLC-MS, which allowed the identification of 46 compounds, being quercetin and chlorogenic acid derivatives representative of 86% of the total of phenolic compounds identified in hydrophilic fraction of the aqueous extract. Naringenin (27.2%) was the major compound present in the lipophilic fraction. The antiproliferative effects of the S. nigra extract were evaluated using the colon cancer cell lines RKO, HCT-116, Caco-2 and the extract’s antigenotoxic potential was evaluated by the Comet assay in RKO cells. The RKO cells were the most susceptible to S. nigra flower extract (IC50 = 1250 µg mL−1). Moreover, the extract showed antimicrobial activity against Gram-positive bacteria, particularly Staphylococcus aureus and S. epidermidis. These results show that S. nigra-based extracts can be an important dietary source of bioactive phenolic compounds that contribute to health-span improving life quality, demonstrating their potential as nutraceutical, functional foods and/or cosmetic components for therapeutic purposes.

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Section: Phenolic Content and Antioxidant Activitymentioning

confidence: 95%

Section: Phenolic Content and Antioxidant Activitymentioning

confidence: 98%

Chemical Characterization of Sambucus nigra L. Flowers Aqueous Extract and Its Biological Implications

et al. 2021

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“…Elderberries contain different active ingredients and phytochemicals, including (pro)anthocyanins (Stuppner et al, 2020), flavonoids and (poly)phenolic acids (EMA, Committee on Herbal Medicinal Products, 2014;Ferreira et al, 2020), all of which are supposed to make their contributions to described antimicrobial and antiviral effects as well as immunomodulation, as shown in different preclinical studies (Barak et al, 2001(Barak et al, , 2002Frank et al, 2020;Kinoshita et al, 2012;Roschek et al, 2009;Torabian et al, 2019). As such, it could be shown that elderberry and in particular cyanidin 3-glucoside, its primary anthocyanin compound, reduce the infectivity of the influenza virus at different infection stages (Torabian et al, 2019) and elderberry extract reduces infectivity by binding to H1N1 virions, thereby blocking the ability to infect host cells (Roschek et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

A new high-quality elderberry plant extract exerts antiviral and immunomodulatory effects in vitro and ex vivo

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et al. 2021

Food and Agricultural Immunology

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Infections of the respiratory system, including common cold and influenza, are affecting people worldwide and are more or less prone to spread depending on the season and viral load of the host. For reducing symptoms and duration of illness, treatment options to standard prescribed drugs are in demand. Natural products could provide immune-supporting treatment alternatives. Elderberry extracts have been used in traditional medicine for the treatment of respiratory infections for decades and numerous studies describe the beneficial effects of elderberries on the immune system and respiratory infectious disease. We investigated the immunomodulative and antiviral effects of a high-quality, anthocyanin-enriched elderberry fruit extract (eldosamb®). Results reveal that elderberry extract reduced the secretion of pro-inflammatory cytokines TNF-α and IFN-γ, leading to a shift towards the Th2-Helper cell response and showing antiviral efficacy against the MVA virus. Thus, with its anti-inflammatory and antiviral bioactivity the proprietary elderberry extract suggests its use as an immunomodulatory health product.

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“…Elderflower extract at a concentration of 252 μg/ml inhibited the influenza A virus (H1N1)-induced Madin-Darby canine kidney (MDCK) cell infection (Sidor and Gramza-Michałowska, 2015). Infusions of elderflowers are a good traditional remedy for many kinds of diseases, such as, for the treatment of inflammation, joint pain, skin disorders, colds, fever, respiratory disturbances, asthma treatment and as a diuretic (Salvador et al, 2019;Ferreira et al, 2020). Elderflower's traditional use for the relief of early symptoms of common cold has been found to fulfill the requirement of medicinal use for at least 30 years according to the Committee on Herbal Medicinal Products of the European Medicines Agency (Salvador et al, 2019).…”

Section: Adoxaceaementioning

confidence: 99%

A Comparison Study on Traditional Mixtures of Herbal Teas Used in Eastern Mediterranean Area

et al. 2021

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Multipurpose herbal teas with numerous ingredients, in which flowers are the main component, are common in the traditional medicine and pharmacy of Greece and the Eastern Mediterranean countries. In this study, we combine ethnobotany and ethnopharmacology field work techniques and botany and pharmacognosy laboratory methods for the study of traditional herbal mixtures with flowers, we identify their botanical ingredients and record the local medicinal uses of these mixtures, in Greece, Lebanon, Syria, Iran and Turkey. These, and their industrial versions, are analyzed, using morphological and multivariate analysis techniques in order to determine marker species, relevant patterns of combination and local styles. The medicinal properties attributed to the different flowers are discussed in relation with their role in the mixtures. These blends are consumed for their relaxing, digestive, and anti-infective properties. These mixtures are not consumed as a treatment when one is sick but rather to avoid getting sick, as a preventive measure. The formulations can reach forty ingredients (sarantha in Greek, arbain in Arabic language of Palestine), usually entire or coarsely chopped in the more traditional formulations, leading to extreme variability of individual doses. We ask what biological signification this randomness can have. To give an answer requires new and more comprehensive pharmacological approaches. The flowers of Rosaceae, Asteraceae, Lamiaceae, Malvaceae and Fabaceae species characterize these mixtures in which other materials (roots, leaves, and fruits) and other species are present as well. Flowers of some species, particularly of Fabaceae, are exclusively used in mixtures, and their use in monospecific herbal teas is not yet recorded. We draw attention on the urgent need in exhaustively recording in Greece and the Near East, the formulation and use of traditional herbal mixtures and their numerous local variants. To consider these mixtures and the contribution of flowers (most mixtures receive the general name of tea of flowers) merits further extensive study.

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Sambucus nigra L. Fruits and Flowers: Chemical Composition and Related Bioactivities

Cited by 47 publications

References 71 publications

Chemical Characterization of Sambucus nigra L. Flowers Aqueous Extract and Its Biological Implications

Chemical Characterization of Sambucus nigra L. Flowers Aqueous Extract and Its Biological Implications

A new high-quality elderberry plant extract exerts antiviral and immunomodulatory effects in vitro and ex vivo

A Comparison Study on Traditional Mixtures of Herbal Teas Used in Eastern Mediterranean Area

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