<i>Salmonella enterica</i> Serotype Choleraesuis Infections in Pediatric Patients

Chiu, Cheng Hsun; Chuang, Chih Hsien; Chiu, Shun; Su, Lin; Lin, Tzou Yien

doi:10.1542/peds.2005-2251

Cited by 32 publications

(27 citation statements)

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“…Therefore, contaminated swine fecal matter can serve as a reservoir for Salmonella serovar Choleraesuis (16). This organism also causes invasive infections in humans, especially elderly people with underlying diseases (8,12). It is believed that humans can acquire Salmonella serovar Choleraesuis from the contaminated meat of food animals.…”

Section: Discussionmentioning

confidence: 99%

“…This pathogen can occasionally infect humans. It often causes severe invasive diseases, primarily septicemia with little involvement of the intestinal tract in humans, especially in elderly people with underlying diseases (8,12). As a major isolated serovar of Salmonella from swine (13), the impact of Salmonella serovar Choleraesuis on public health differs greatly in different geographic areas.…”

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confidence: 99%

“…Antimicrobial therapy is necessary for the treatment of Salmonella serovar Choleraesuis infections, because approximately 78% of the infected individuals in Taiwan developed bacteremia with little or no intestinal involvement (12). The conventional antimicrobial agents, including ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole, used to be the drugs of choice for the treatment of salmonellosis before the 1980s.…”

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confidence: 99%

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Epidemiologic Relationship between Fluoroquinolone-ResistantSalmonella entericaSerovar Choleraesuis Strains Isolated from Humans and Pigs in Taiwan (1997 to 2002)

et al. 2005

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The emergence of ciprofloxacin-resistant Salmonella enterica serovar Choleraesuis in recent years has become an important public health issue in Taiwan. The resistant strains that cause human infections are considered to be from pigs. In this study, we characterized 157 swine and 42 human Salmonella serovar Choleraesuis isolates by pulsed-field gel electrophoresis (PFGE) and drug susceptibility testing to investigate the epidemiologic relationship among the isolates. By PFGE analyses, two major clusters (clusters GA and GB) were identified. Isolates in cluster GA were of both human and swine origins, while those in cluster GB were from pigs only. Among the various genotypes identified, genotype gt-1a was the most prevalent, which was found in 71% (30 of 42) and 48% (76 of 157) of human and swine isolates, respectively. The susceptibility tests for the 106 gt-1a isolates identified 44 susceptibility profiles and showed that 73% of human isolates and 34% of swine isolates were resistant to three fluoroquinolones (ciprofloxacin, enrofloxacin, and norfloxacin). Our findings indicate that a clonal group of Salmonella serovar Choleraesuis may have been circulating in human and swine populations in Taiwan for years and that the fluoroquinolone-resistant Salmonella serovar Choleraesuis strains most likely evolved from a gt-1a clone that emerged in 2000 and that then caused widespread infections in humans and pigs. Nevertheless, it is still debatable whether those Salmonella infections in humans are caused by isolates derived from pigs, on the basis of the higher fluoroquinolone and other antimicrobial resistance percentages in human isolates than in pig isolates.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Epidemiologic Relationship between Fluoroquinolone-ResistantSalmonella entericaSerovar Choleraesuis Strains Isolated from Humans and Pigs in Taiwan (1997 to 2002)

et al. 2005

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“…However when it infects humans, it tends to cause invasive infections. [1] In the first case salmonellae were repeatedly isolated from the burn wound and amputation stump. The strain was sensitive to ciprofloxacin.…”

Section: Case Two -Neonatal Meningitismentioning

confidence: 99%

Salmonella Enterica Serotype Choleraesuis, a Rare Pathogen – Report of Two Cases

Shah¹,

Kulkarni²,

Udgaonkar³

et al. 2013

jemds

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Nontyphoidal salmonellosis is well known clinical entity. Outbreaks of gastroenteritis, septicemia and meningitis caused by different nontyphoidal salmonellae have been reported in the past. S. choleraesuis is the highly swine adapted serotype of salmonella causing swine paratyphoid. It is extremely invasive and may be isolated from other animals, including man.We report two cases of S. cholerasuis infections, one in electric burn wound and the other in a fatal case of meningitis. In the first case the organism was repeatedly isolated from the wound. The source of infection was the patient's intestine. This is very interesting as human carriage of S. cholerasuis is rare.

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“…2 Two serovars, S. Choleraesuis and S. Paratyphi C, cause metastatic purulent infections, an uncommon clinical form of invasive disease. [3][4][5] In the US and Europe, gastroenteritis due to NTS serovars, a common disease, may occasionally be accompanied by invasive bacteremic disease. Susceptible hosts for invasive NTS disease include infants < 3 mo of age, 6- …”

Section: Introductionmentioning

confidence: 99%

Glycoconjugate vaccine strategies for protection against invasiveSalmonellainfections

Simon

Levine

2012

Human Vaccines & Immunotherapeutics

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Salmonella enterica Serotype Choleraesuis Infections in Pediatric Patients

Cited by 32 publications

References 11 publications

Epidemiologic Relationship between Fluoroquinolone-ResistantSalmonella entericaSerovar Choleraesuis Strains Isolated from Humans and Pigs in Taiwan (1997 to 2002)

Epidemiologic Relationship between Fluoroquinolone-ResistantSalmonella entericaSerovar Choleraesuis Strains Isolated from Humans and Pigs in Taiwan (1997 to 2002)

Salmonella Enterica Serotype Choleraesuis, a Rare Pathogen – Report of Two Cases

Glycoconjugate vaccine strategies for protection against invasiveSalmonellainfections

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