Glycoconjugate vaccine strategies for protection against invasive<i>Salmonella</i>infections

Simon, Raphael; Levine, Myron M.

doi:10.4161/hv.19158

Cited by 55 publications

(51 citation statements)

References 55 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here at the Center for Vaccine Development of the University of Maryland School of Medicine, efforts to develop a live attenuated vaccine are under way, based on wellcharacterized attenuating gene deletions (14). Another strategy that has proven successful in generating functional immunity and protection against S. Typhimurium and S. Enteritidis relies on conjugate vaccines in which flagellin serves as a carrier for core O polysaccharide (61). We expect that, based on differences in their O polysaccharides, we would need vaccines against both serogroups C1 and C2 to elicit broad protection against all serogroup C serovars.…”

Section: Vaccines Against Serogroup C Ntsmentioning

confidence: 99%

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed

Fuche

Sow

Simon

et al. 2016

Clin Vaccine Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Vaccines Against Serogroup C Ntsmentioning

confidence: 99%

Salmonella Serogroup C: Current Status of Vaccines and Why They Are Needed

Fuche

Sow

Simon

et al. 2016

Clin Vaccine Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, nontyphoidal Salmonella (NTS) serovars such as S. Typhimurium cause bacteremia in young children and immunologically compromised adults (4). Because S. Typhi and NTS serovars frequently persist in their hosts and thereby contribute to the transmission to naive individuals (5), these pathogens are considered important targets for vaccinationcontrolled diseases (6)(7)(8). Hence it is important to develop and to characterize subunit vaccines that focus protective immune responses on the critical components of the pathogen.…”

mentioning

confidence: 99%

IFN-γ–Producing CD4+ T Cells Promote Generation of Protective Germinal Center–Derived IgM+ B Cell Memory against Salmonella Typhi

Pérez-Shibayama

Gil‐Cruz

Pastelin-Palacios

et al. 2014

The Journal of Immunology

View full text Add to dashboard Cite

Abs play a significant role in protection against the intracellular bacterium Salmonella Typhi. In this article, we investigated how long-term protective IgM responses can be elicited by a S. Typhi outer-membrane protein C– and F–based subunit vaccine (porins). We found that repeated Ag exposure promoted a CD4+ T cell–dependent germinal center reaction that generated mutated IgM-producing B cells and was accompanied by a strong expansion of IFN-γ–secreting T follicular helper cells. Genetic ablation of individual cytokine receptors revealed that both IFN-γ and IL-17 are required for optimal germinal center reactions and production of porin-specific memory IgM+ B cells. However, more profound reduction of porin-specific IgM B cell responses in the absence of IFN-γR signaling indicated that this cytokine plays a dominant role. Importantly, mutated IgM mAbs against porins exhibited bactericidal capacity and efficiently augmented S. Typhi clearance. In conclusion, repeated vaccination with S. Typhi porins programs type I T follicular helper cell responses that contribute to the diversification of B cell memory and promote the generation of protective IgM Abs.

show abstract

“…They concluded that the O-antigen region seems to capture most of the humoral response to whole LPS and contributes substantially to the observed vibriocidal responses. These results support efforts for O-antigen conjugate vaccines, an approach that is being pursued to prevent disease caused by Salmonella, Shigella, and other enteric pathogens (32,45).…”

mentioning

confidence: 67%