<i>Roseomonas</i>species infections in humans: a systematic review

Ιωάννου, Πέτρος; Mavrikaki, Vasiliki; Kofteridis, Diamantis P.

doi:10.1080/1120009x.2020.1785742

Cited by 18 publications

(38 citation statements)

References 62 publications

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“…Presence of a CVC, malignancy on chemotherapy or previous chemotherapy, parenteral nutrition, recent surgery and recent antibiotic use were highly prevalent in patients with K ohmeri fungemia, implicating these factors as important risks. Importantly, these factors have been repeatedly identified to predispose to other invasive mycoses as well 23,42,47–49 . Indeed, since Candida species and K ohmeri belong to the same family, it is not of surprise that they share common properties regarding pathogenicity; thus, having common predisposing factors for invasive fungal infection was not an unexpected finding 48 …”

Section: Discussionmentioning

confidence: 98%

“…The last decades, several emerging fungi have been described to cause invasive disease in immunocompromised individuals 40 . Besides species of the Candida genus, several other fungi have emerged as potential pathogens in this patient population 41,42 . During the last decades, several infections caused by K ohmeri have been reported; however, their characteristics have not been systematically characterised.…”

Section: Discussionmentioning

confidence: 99%

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Kodamaea ohmeri infections in humans: A systematic review

Ιωάννου

Papakitsou

2020

Mycoses

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Summary Background Kodamaea ohmeri, previously known as Pichia ohmeri or Yamadazyma ohmeri, belongs to the Saccharomycetaceae family and the Ascomycetae class, is the telomorphic form of C guilliermondii var. membranaefaciens and is frequently mistaken for Candida, as they belong to the same family. It has been isolated from environmental sources, such as sand, pools, seawater and fruits, while the last decades it is recognised as a rare pathogen that causes life‐threatening infections in humans. The purpose of this study was to systemically review all published cases of K ohmeri infections in the literature and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. Methods Systematic review of PubMed (through 27th December 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of K ohmeri infections. Results A total of 35 studies, containing data of 44 patients, were included in the analysis. The most common K ohmeri infections were those of the bloodstream, infective endocarditis and onychomycosis. Previous antibiotic use, presence of a central venous catheter, parenteral nutrition and cancer were very common among patients. Mortality was high in the case of fungemias but low for other types of infections. Amphotericin B and fluconazole are the most common agents used for treatment, even though alarming MICs for fluconazole were noted. Conclusions This systematic review thoroughly describes infections by K ohmeri and provides information on their epidemiology, clinical presentation, microbiology, antibiotic resistance patterns, treatment and outcomes.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Kodamaea ohmeri infections in humans: A systematic review

Ιωάννου

Papakitsou

2020

Mycoses

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“…Methylobacterium may be an important genus that can protect the host against pathogens in fish skin [54]. R. gilardii has been recognized as an opportunistic pathogen that can lead to infections, especially in immunocompromised humans [55]. Therefore, the enrichment of S. aquatilis, Methylobacterium, and R. gilardii in the gill and stomach mucosae might play vital roles in stimulating host mucosal immunity and antagonizing pathogen colonization.…”

Section: Discussionmentioning

confidence: 99%

Taxonomic and Functional Characteristics of the Gill and Gastrointestinal Microbiota and Its Correlation with Intestinal Metabolites in NEW GIFT Strain of Farmed Adult Nile Tilapia (Oreochromis niloticus)

Zhang

Lin

et al. 2021

Microorganisms

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The gill and gastrointestinal tract are primary entry routes for pathogens. The symbiotic microbiota are essential to the health, nutrition and disease of fish. Though the intestinal microbiota of Nile tilapia (Oreochromis niloticus) has been extensively studied, information on the mucosa-associated microbiota of this species, especially the gill and gastrointestinal mucosa-associated microbiota, is lacking. This study aimed to characterize the gill and gastrointestinal mucosa- and digesta-associated microbiota, as well as the intestinal metabolite profiles in the New Genetically Improved Farmed Tilapia (NEW GIFT) strain of farmed adult Nile tilapia by high-throughput sequencing and gas chromatography/mass spectrometry metabolomics. The diversity, structure, composition, and predicted function of gastrointestinal microbiota were significantly different across gastrointestinal regions and sample types (Welch t-test; p < 0.05). By comparing the mucosa- and digesta-associated microbiota, linear discriminant analysis (LDA) effect size (LEfSe) analysis revealed that Pelomonas, Ralstoniapickettii, Comamonadaceae, and Staphylococcus were significantly enriched in the mucosa-associated microbiota, whereas many bacterial taxa were significantly enriched in the digesta-associated microbiota, including Chitinophagaceae, Cetobacterium, CandidatusCompetibacter, Methyloparacoccus, and chloroplast (LDA score > 3.5). Furthermore, Undibacterium, Escherichia–Shigella, Paeniclostridium, and Cetobacterium were dominant in the intestinal contents and mucosae, whereas Sphingomonasaquatilis and Roseomonasgilardii were commonly found in the gill and stomach mucosae. The Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2) analysis revealed that the predictive function of digesta-associated microbiota significantly differed from that of mucosa-associated microbiota (R = 0.8152, p = 0.0001). In addition, our results showed a significant interdependence between specific intestinal microbes and metabolites. Notably, the relative abundance values of several potentially beneficial microbes, including Undibacterium, Crenothrix, and Cetobacterium, were positively correlated with most intestinal metabolites, whereas the relative abundance values of some potential opportunistic pathogens, including Acinetobacter, Mycobacterium, Escherichia–Shigella, Paeniclostridium, Aeromonas, and Clostridiumsensustricto 1, were negatively correlated with most intestinal metabolites. This study revealed the characteristics of gill and gastrointestinal mucosa-associated and digesta-associated microbiota of farmed Nile tilapia and identified a close correlation between intestinal microbes and metabolites. The results serve as a basis for the effective application of targeted probiotics or prebiotics in the diet to regulate the nutrition and health of farmed tilapia.

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“…The idea that without removing the offending device the organism will continue to grow into the bloodstream leading to significant morbidities and mortalities. Of note, some patients have been managed by the removal of CVC only without antifungal administration because of the low pathogen virulence 8 . Despite the immediate removal of the CVC when yeast was identified in the blood, our patient continued to fever which only settled after switching to Amphotericin.…”

Section: Discussionmentioning

confidence: 82%

“…Rhodotorula fungemia was reported in 48.6% of all Rhodotorula‐related infection in a recent review with R mucilaginosa is the most causative species, while the presence of CVC was encountered in 81.6% of the cases 8 . The majority of R mucilaginosa cases in the literature are from patients with immune dysfunction while only a few cases are immunocompetent 9‐14 …”

Section: Discussionmentioning

confidence: 99%