Central line‐associated <i>Rhodotorula mucilaginosa</i> fungemia in an immunocompetent host: Case report and review of the literature

Goravey, Wael; Ali, Gawahir A.; Abid, Fatma Ben; Ibrahim, Emad; Maslamani, Muna Al; Hadi, Hamad Abdel

doi:10.1002/ccr3.3969

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…Rhodotorula is commonly associated with skin barrier disruption [56], and its presence in immunocompromised individuals is often severe [57]. In a recent study, risks caused by the blooming of the Rhodotorula genus were addressed, highlighting the increased risk posed in immune-challenged individuals and infants [58].…”

Section: Discussionmentioning

confidence: 99%

ITS2 Sequencing and Targeted Meta-Proteomics of Infant Gut Mycobiome Reveal the Functional Role of Rhodotorula sp. during Atopic Dermatitis Manifestation

Mok

Suratanon

Roytrakul

et al. 2021

JoF

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Association between the gut mycobiome and atopic dermatitis was investigated in 9–12-month-old infants using metagenomics. Two groups of atopic dermatitis infants were classified according to their symptom development as outgrown (recovered) and persisted (still undergoing). The evenness and diversity of the mycobiome in the persisted group were higher than in the healthy and outgrown groups. Dysbiosis of the microbiome in the persisted group was observed by a reduction in the Ascomycota/Basidiomycota ratio. Five fungi were selected as markers from each sample group. In the persisted group, Rhodotorula sp. abundance increased significantly, while Wickerhamomyces sp. and Kodamaea sp. abundance increased in the healthy group, and Acremonium sp. and Rhizopus sp. abundance increased considerably in the outgrown group. Metaproteomic analysis revealed that the persisted group had a high abundance of fungal proteins, particularly those from Rhodotorula sp. Unique proteins such as RAN-binding protein 1 and glycerol kinase from Rhodotorula sp. were hypothesized to be related to atopic dermatitis manifestation in infants.

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Section: Discussionmentioning

confidence: 99%

ITS2 Sequencing and Targeted Meta-Proteomics of Infant Gut Mycobiome Reveal the Functional Role of Rhodotorula sp. during Atopic Dermatitis Manifestation

Mok

Suratanon

Roytrakul

et al. 2021

JoF

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“…This identified three taxa enriched in children that would develop CDA ( q < 0.05 and OR of 1.06–1.14): Meyerozyma guilliermondi, Debaryomyces hansenii , and Rhodotorula mucilaginosa . These species are widespread in the environment, but also opportunistic pathogens 4 , 41 , 42 . Further studies are needed to establish whether these fungi contribute to the etiology of celiac disease.…”

Section: Resultsmentioning

confidence: 99%

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study

et al. 2022

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Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the development of the fungal population from infancy into childhood. Here, as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study, we examine stool samples of 888 children from 3 to 48 months and find considerable differences between fungi and bacteria. The metagenomic relative abundance of fungi was extremely low but increased while weaning from milk and formula. Overall fungal diversity remained constant over time, in contrast with the increase in bacterial diversity. Fungal profiles had high temporal variation, but there was less variation from month-to-month in an individual than among different children of the same age. Fungal composition varied with geography, diet, and the use of probiotics. Multiple Candida spp. were at higher relative abundance in children than adults, while Malassezia and certain food-associated fungi were lower in children. There were only subtle fungal differences associated with the subset of children that developed islet autoimmunity or type 1 diabetes. Having proper fungal exposures may be crucial for children to establish appropriate responses to fungi and limit the risk of infection: the data here suggests those gastrointestinal exposures are limited and variable.

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“…Rhodotorula species are commensal fungi belonging to the family of Sporidiobolaceae with R. mucilaginosa, R. glutinis, and R. minuta are the most clinical encountered species typically especially in the Asia Pacific region, leading to invasive fungal infections especially in immunocompromise patients [1]. Rhodotorula mucilaginosa is an emerging pathogen with a high resistance profile and the mortality rate has been reported around 10% with the complications of sepsis, shock and organ dysfunction [2][3][4]. It forms salmon-pink colonies when cultured on standard artificial media -a vital and early clue to its presence in a fungal culture [5].…”

Section: Introductionmentioning

confidence: 99%

“…It forms salmon-pink colonies when cultured on standard artificial media -a vital and early clue to its presence in a fungal culture [5]. In order to prevent the risk of treatment failure, it is crucial for a timely clinical assessment in detecting Rhodotorula mucilaginosa infection so that appropriate antifungal therapy can be initiated early [4]. We report a case of a traumatic patient who developed Rhodotorula mucilaginosa fungaemua in an immunocompetent host who received early antifungal selection to prevent potential morbidity and mortality associated with it.…”

Section: Introductionmentioning

confidence: 99%

<em>Rhodotorula mucilaginosa </em>Fungaemia in an Infected Biloma Patient Following a Traumatic Liver Injury

Mokhtar,

Rahman,

Abdullah

et al. 2024

Preprint

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Rhodotorula mucilaginosa fungaemia is rare and highly resistance to antifungal therapy. We herein report a case involving a 31-year-old male admitted after a high-velocity road traffic accident. He sustained a grade IV liver injury with right hepatic vein thrombosis, necessitated an urgent laparotomy. Post-operatively, repeated imaging of the abdomen revealed presence of biloma. Percutaneous subdiaphragmatic drainage was done but appeared ineffective, prompting second surgery for a urgent hemi-hepatectomy. Patient then was nursed in the intensive care unit (ICU) however during his stay in the ICU he became more sepsis evident by worsening ventilatory support and rise in septic parameters from the biochemistry parameters. Despite on intravenous piperacillin-tazobactam and fluconazole, his septic parameters did not improve and a full septic workup was done and was found to be positive for Rhodotorula mucilaginosa from the blood cultures. After discussion with the infectious disease physicians and clinical microbiologist, it was decided to initiate a course of intravenous meropenem and amphotericin B based on minimum inhibitory concentration (MIC) values, considering the patient's extended ICU stay and catheter use. Eventually, successful weaning off mechanical ventilation was discharge from ICU care. This case underscores the necessity of individualized approaches, combining timely imaging, appropriate drainage techniques, and tailored treatments to optimize outcomes for such intricate post-traumatic complications.

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Central line‐associated Rhodotorula mucilaginosa fungemia in an immunocompetent host: Case report and review of the literature

Abstract: Rhodotorula mucilaginosa is an emerging fungal infection with the ability of biofilms formation. The identification of R mucilaginosa fungemia should trigger reflexes of prompt central venous line removal and using Amphotericin therapy.

Cited by 7 publications

References 19 publications

ITS2 Sequencing and Targeted Meta-Proteomics of Infant Gut Mycobiome Reveal the Functional Role of Rhodotorula sp. during Atopic Dermatitis Manifestation

ITS2 Sequencing and Targeted Meta-Proteomics of Infant Gut Mycobiome Reveal the Functional Role of Rhodotorula sp. during Atopic Dermatitis Manifestation

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study

<em>Rhodotorula mucilaginosa </em>Fungaemia in an Infected Biloma Patient Following a Traumatic Liver Injury

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