<i>Retracted</i>: Evaluation of the effect of pentoxifylline on white blood cell count in serum and peritoneal fluid in female rats with endometriosis

Mohammadzadeh, Afsaneh; Heidari, Mahnaz; Soltanghoraee, Haleh; Jeddi-Tehrani, Mahmood; Novin, Marefat Ghaffari; Akhondi, Mohammad Mehdi; Zeraati, Hojjat; Mohammadzadeh, Farzaneh

doi:10.1111/j.1447-0756.2008.00745.x

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…Through the inhibition of phosphodiesterase in monocytes and macrophages, the drug suppresses cytokine production, mainly TNF-a in macrophages. Thus, it also has been used in the treatment of rheumatoid arthritis and inflammatory bowel disease (128,129). Based on the same indirect anti-TNF-a mechanism, this drug has been considered for the treatment of endometriosis.…”

Section: Pentoxifyllinementioning

confidence: 99%

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Pharmacologic therapies in endometriosis: a systematic review

Soares¹,

Martínez-Varea

Hidalgo-Mora

et al. 2012

Fertility and Sterility

137

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Section: Pentoxifyllinementioning

confidence: 99%

“…In the rat model, implants of endometrial tissue in different locations (subcutaneous tissue, peritoneal surface, and ovarian area) were used to test the effect of pentoxifylline on lesions (128,129). Statistically significant reductions in the weight, volume, and number of lesions were documented (128,129).…”

Section: Pentoxifyllinementioning

confidence: 99%

Pharmacologic therapies in endometriosis: a systematic review

Soares¹,

Martínez-Varea

Hidalgo-Mora

et al. 2012

Fertility and Sterility

137

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“…Pa ral lel to the fin dings in the li te ra tu re, the gro up that rece i ved GnRHa tre at ment had sig ni fi cant re duc tions in the are as of the en do met ri o tic fo ci and ad he si on sco res com pa red to the rats in the con trol gro up. [5][6][7]21 Ho we ver, in ad di ti on to the high costs, it car ri es the risk of os te o po ro sis when used for long pe ri ods of ti me. Ad di ti o nally, GnRHa tre atment pro du ces se ve ral tro ub le so me si de ef fects beca u se of its strong an ti es tro ge nic ef fects, and re lap se might oc cur af ter the ces sa ti on of tre atment.…”

Section: Discussionmentioning

confidence: 99%

“…5 The tre at ment of en do metri o sis was in ves ti ga ted in ear li er stu di es with a rat mo del using GnRHa and go na dot ro pin re le a sing hor mo ne an ta go nists and va ri o us agents such as pen to xiphy lli ne, doxyc ycli ne, and le va mi zol. [5][6][7][8][9] GnRH ana lo gu es are be ing used ef fec ti vely in the tre at ment of en do met ri o sis and the re is a con sensus in the cur rent li te ra tu re that the se agents are ef fec ti ve. 5,9 The use of GnRHa with monthly injec ti ons or in jec ti ons with 3-month in ter vals in hibits ova ri an es tro gen synthe sis and forms a hypo es tro ge nic en vi ron ment, thus di mi nis hing the en do met ri o sis fo ci.…”

mentioning

confidence: 99%

Therapeutic Efficiency of Tibolone in a Rat Endometriosis Model

Şimşek¹,

Ceyhan²,

Üstün³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : This study ai med to eva lu a te the the ra pe u tic ef fi ci ency of ti bo lo ne in an ex pe ri men tal rat mo del of in tra-ab do mi nal en do met ri o sis. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In this ex pe rimen tal study, in tra-ab do mi nal en do met ri o sis was in du ced in 30 fe ma le rats sur gi cally. Fo ur we eks af ter this pro ce du re, la pa ro tomy was per for med again. The di men si ons of the en do met ri o sis fo ci were re cor ded and right af ter, the ope ra ti on was comp le ted. Rats we re ran domly di vi ded in to thre e gro ups and sub se qu ently, the tre at ment was star ted. In the first gro up (n= 8), a sing le do se of 1 cc 0.9% NaCl was in jec ted sub cu ta ne o usly. In the se cond gro up (n= 8), in tra mus cu lar in jec ti on of 1 mg le up ro lid ace ta te was ad mi nis te red. In the third gro up (n= 8), 1 mg/kg/day of ti bo lo ne was gi ven by ga va ge. At the end of 4-we eks of drug ad mi nis tra ti on, la pa ro tomy was per for med to all rats. The di men si ons of the en do met ri o sis fo ci we re re cor ded. Af ter wards, all the rats we re sac ri fi ced. The dif fe ren ces in the are as of en do met ri o tic imp lants and ad he si on sco res we re com pa red bet we en the gro ups. R Re e s su ul lt ts s: : The di men si ons of the en do met ri o sis fo ci in the gro ups tre a ted with le up ro lid (p< 0.05) and ti bo lo ne (p< 0.05) we re sig ni fi cantly di mi nis hed compared to that of the con trol gro up. No sta tis ti cally sig ni fi cant dif fe ren ces we re fo und bet we en the tre at ment gro ups. C Co on nc c l lu u s si i o on n: : In a rat en do met ri o sis mo del, ti bo lo ne has a si mi lar ef fi ci ency as that of le up ro lid ace ta te, an agent used for con ven ti o nal me di cal tre at ment of en do met ri o sis. With its an dro ge nic and pro ges ta ge nic charac te ris tics, ti bo lo ne de ser ves at ten ti on as an al ter na ti ve agent in the me di cal tre at ment of en domet ri o sis in hu man. K Ke ey y W Wo or rd ds s: : Rats; endometriosis; gonadotropin-releasing hormone; tibolone Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma da ka rın içi en do met ri o zis li de ney sel sı çan mo de lin de ti bo lon un te ra pö tik et kin li ği nin de ğer len di ril me si amaç lan dı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu de ney sel ça lış ma da, 30 di şi sı çan -da ka rın içi cer ra hi en do met ri o zis mey da na ge ti ril di. Bu iş lem den dört haf ta son ra tekrar la pa ro tomi ya pıl dı. En do met ri o zis odak la rı nın bo yut la rı kay de dil di he men ar dın dan ope ras yon ta mam lan dı. Sı çan lar rast ge le üç gru ba ay rıl dı ve da ha son ra te da vi baş lan dı. Bi rin ci gru ba (n= 8), NaCl 1 cc %0.9 tek doz ola rak cilt al tı na en jek te edil di. İkin ci gru ba (n= 8), le up ro lid ase tat 1 mg in tra mus kü ler ola rak uy gu lan dı. Üçün cü gru ba (n= 8), ti bo lon 1mg/kg/gün ola rak ga vaj ile ve ril di. Dört haf ta ilaç alı mı nın son ra s...

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“…Th e drug is known to suppress cytokine production, mainly TNF-α in macrophages which induces VEGF production 95 . In vitro animal models showed that the number, volume and weight of lessions were significantly reduced aft er PTX injection to endometriotic tissue 96 .…”

Section: Pentoxifylline (Ptx)mentioning

confidence: 99%