Rapid Communication: Protective Effect of a Nuclear FactorκB Inhibitor, Pyrolidium Dithiocarbamate, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

Abstract

This experiment has shown the role of transcription factors, NF-kappaB, and iNOS in ethylene glycol-induced crystal depositions in renal tubules.

Protective Effect of a Potent Antioxidant, Pomegranate Juice, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

“…14 The blockade of NF-B activation by antioxidants has been suggested to be an effective strategy for the management of urolithiasis and arteriosclerosis. 4,14 In our previous study, we found that PDTC has prevented CaOx precipitation in an experimental rat model with kidney stones that were induced by EG administitarion. 4 It is clear from previous in vitro and in vivo studies that Ox-induced peroxidative injury is involved in the nucleation aggregation and development of CaOx stone disease.…”

“…4,14 In our previous study, we found that PDTC has prevented CaOx precipitation in an experimental rat model with kidney stones that were induced by EG administitarion. 4 It is clear from previous in vitro and in vivo studies that Ox-induced peroxidative injury is involved in the nucleation aggregation and development of CaOx stone disease. 25,26 The cell is endowed with several antioxidant systems, including enzymatic (superoxide dismutase [SOD], catalase, and GSH peroxidase) and nonenzymatic-eg, reduced GSH, vitamins A, E, and C to limit the extend of lipid peroxidation.…”

“…8 In our previous study, we showed the MDA and nitric oxide (NO) concentrations were significantly higher and reduced glutathione (GSH) concentration was lower in the kidney of EG-given groups compared with EG ϩ pyrolidium dithiocarbamate (PDTC) (NF-B inhibitor). 4 Inducible nitric oxide synthase (iNOS) is one of the three NOS isoforms that is affected and increases by NF-through increased tissue damage. The process of iNOS expression involves different signal transduction pathways, including nuclear translocation of the transcription factor NF-B.…”

“…4 Pomegranate juice (PJ) is a rich source of potent polyphenolic, flavonoid antioxidants (anthocyanins). Edible parts of pomegranate fruit (about 50% of total fruit weight) comprise 80% juice and 20% seeds.…”

Protective Effect of the Nuclear Factor Kappa B Inhibitor Pyrrolidine Dithiocarbamate in Lung Injury in Rats with Streptozotocin-Induced Diabetes

“…Pyrrolidine dithiocarbamate (PDTC) is a metal chelator and an antioxidant, and has potent anti-inflammatory properties due to its ability to suppress NF-ĸB [7,15,16]. Keeping in mind that NF-ĸB activation may have a crucial role on the end-organ injury caused by DM, we studied the effects of PDTC on the inhibition of NF-ĸB activation and on possible lung injury due to streptozotocin-induced DM.…”