Radix Ranunculi ternati: review of its chemical constituents, pharmacology, quality control and clinical applications

Abstract

Objectives Radix ranunculi ternati (RRT) is widely used as traditional and folk medicine distributed in China, as well as in Kyushu and Shikoku in Japan. Although RRT has a short history of use as medicine, it has a high medicinal value. This study summarizes the research progress on the chemical constituents, pharmacological activity, quality control measures and clinical applications to provide a valuable and exhaustive reference for the development and application of RRT. Key findings Phytochemical studies showed that this plant mainly contains glycosides, organic acids, esters, sterols, flavonoids, alkaloids and volatile oils. The pharmacological activity of RRT includes immune regulation, anti-tumour, anti-tuberculosis, antioxidant, antibacterial, hepatoprotective and anti-inflammatory effects. This plant is especially effective in the treatment of cancer, tuberculosis, thyroid and nasopharynges disorders.

Investigation on the mechanism of Ranunculus ternatus Thunb. against esophageal squamous cell carcinoma based on network pharmacology and experimental verification

“…29 active components from the RTE were searched in published literatures [15,[20][21][22][23][24][25][26][27] (Table S1). After eliminating the overlapping proteins, 461 associated proteins were obtained for subsequent analysis.…”

“…Ranunculus ternatus Thunb. is widely used clinically and has been approved for the treatment of cancer [15,16]. Now, it has been further developed for medicinal use in Japan for the treatment of breast cancer, demonstrating signi cant e cacy [17].…”