Investigation on the mechanism of Ranunculus ternatus Thunb. against esophageal squamous cell carcinoma based on network pharmacology and experimental verification
Michen Deng,
Yanhong Deng,
Zu-gui Tang
et al.
Abstract:Purpose
This study was conducted to assess the pharmacological mechanisms of ethyl acetate extract of Ranunculus ternatus Thunb. (RTE) in combating esophageal squamous cell carcinoma (ESCC) through the integration of network pharmacology analysis and experimental validation.
Methods
Utilizing network pharmacology methodologies, potential targets of RTE and targets associated with ESCC were identified from public databases. Subsequently, protein-protein interaction (PPI) network analysis, Gene Ontology (GO) a… Show more
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